| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AQM59919.1 | AQM60146.1 | NPD11_1602 | NPD11_1072 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | birA_ligase: biotin--[acetyl-CoA-carboxylase] ligase; [H] COG0340 Biotin-(acetyl-CoA carboxylase) ligase. | 0.407 |
| AQM59919.1 | ftsZ | NPD11_1602 | NPD11_464 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | 0.644 |
| AQM59919.1 | guaB | NPD11_1602 | NPD11_1506 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.483 |
| AQM59919.1 | nrdR | NPD11_1602 | NPD11_458 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.681 |
| AQM60146.1 | AQM59919.1 | NPD11_1072 | NPD11_1602 | birA_ligase: biotin--[acetyl-CoA-carboxylase] ligase; [H] COG0340 Biotin-(acetyl-CoA carboxylase) ligase. | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.407 |
| AQM60146.1 | guaB | NPD11_1072 | NPD11_1506 | birA_ligase: biotin--[acetyl-CoA-carboxylase] ligase; [H] COG0340 Biotin-(acetyl-CoA carboxylase) ligase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.750 |
| AQM60146.1 | nadE | NPD11_1072 | NPD11_941 | birA_ligase: biotin--[acetyl-CoA-carboxylase] ligase; [H] COG0340 Biotin-(acetyl-CoA carboxylase) ligase. | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.764 |
| AQM60146.1 | nrdR | NPD11_1072 | NPD11_458 | birA_ligase: biotin--[acetyl-CoA-carboxylase] ligase; [H] COG0340 Biotin-(acetyl-CoA carboxylase) ligase. | Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.560 |
| NPD11_459 | NPD11_462 | NPD11_459 | NPD11_462 | spore_YlmC_YmxH: sporulation, YlmC/YmxH family protein; [S] COG1873 Uncharacterized conserved protein. | Sporulation factor SpoIIGA family protein; Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR. Belongs to the peptidase U4 family. | 0.853 |
| NPD11_459 | NPD11_465 | NPD11_459 | NPD11_465 | spore_YlmC_YmxH: sporulation, YlmC/YmxH family protein; [S] COG1873 Uncharacterized conserved protein. | Cell division FtsA family protein; [D] COG0849 Actin-like ATPase involved in cell division. | 0.418 |
| NPD11_459 | ftsZ | NPD11_459 | NPD11_464 | spore_YlmC_YmxH: sporulation, YlmC/YmxH family protein; [S] COG1873 Uncharacterized conserved protein. | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | 0.444 |
| NPD11_459 | nrdR | NPD11_459 | NPD11_458 | spore_YlmC_YmxH: sporulation, YlmC/YmxH family protein; [S] COG1873 Uncharacterized conserved protein. | Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.676 |
| NPD11_459 | sigE | NPD11_459 | NPD11_461 | spore_YlmC_YmxH: sporulation, YlmC/YmxH family protein; [S] COG1873 Uncharacterized conserved protein. | RNA polymerase sigma-E factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | 0.870 |
| NPD11_459 | sigG | NPD11_459 | NPD11_460 | spore_YlmC_YmxH: sporulation, YlmC/YmxH family protein; [S] COG1873 Uncharacterized conserved protein. | RNA polymerase sigma-G factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | 0.902 |
| NPD11_462 | NPD11_459 | NPD11_462 | NPD11_459 | Sporulation factor SpoIIGA family protein; Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR. Belongs to the peptidase U4 family. | spore_YlmC_YmxH: sporulation, YlmC/YmxH family protein; [S] COG1873 Uncharacterized conserved protein. | 0.853 |
| NPD11_462 | NPD11_465 | NPD11_462 | NPD11_465 | Sporulation factor SpoIIGA family protein; Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR. Belongs to the peptidase U4 family. | Cell division FtsA family protein; [D] COG0849 Actin-like ATPase involved in cell division. | 0.479 |
| NPD11_462 | ftsZ | NPD11_462 | NPD11_464 | Sporulation factor SpoIIGA family protein; Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR. Belongs to the peptidase U4 family. | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | 0.638 |
| NPD11_462 | nrdR | NPD11_462 | NPD11_458 | Sporulation factor SpoIIGA family protein; Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR. Belongs to the peptidase U4 family. | Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.580 |
| NPD11_462 | sigE | NPD11_462 | NPD11_461 | Sporulation factor SpoIIGA family protein; Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR. Belongs to the peptidase U4 family. | RNA polymerase sigma-E factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | 0.922 |
| NPD11_462 | sigG | NPD11_462 | NPD11_460 | Sporulation factor SpoIIGA family protein; Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR. Belongs to the peptidase U4 family. | RNA polymerase sigma-G factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | 0.904 |
