Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
NPD11_489Thioredoxin family protein; [OC] COG0526 Thiol-disulfide isomerase and thioredoxins. (108 aa)    
Predicted Functional Partners:
AQM59919.1
Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
  
 
 0.840
lpdA
lipoamide_DH: dihydrolipoyl dehydrogenase; [C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes.
  
 
 0.779
groL
Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
  
 
 0.619
NPD11_488
Hypothetical protein.
       0.534
grpE
grpE family protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depe [...]
  
  
 0.473
AQM60005.1
Pyridine nucleotide-disulfide oxidoreductase family protein; [R] COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases.
  
 
 0.459
trxB
TRX_reduct: thioredoxin-disulfide reductase; [O] COG0492 Thioredoxin reductase.
  
 
 0.459
AQM59961.1
Pyridine nucleotide-disulfide oxidoreductase family protein; [R] COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases.
  
 
 0.459
NPD11_947
Pyridine nucleotide-disulfide oxidoreductase family protein; [O] COG0492 Thioredoxin reductase.
  
 
 0.459
AQM58935.1
Low molecular weight phosphotyrosine phosphatase family protein; [T] COG0394 Protein-tyrosine-phosphatase; Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
  
 
 0.449
Your Current Organism:
Clostridium baratii
NCBI taxonomy Id: 1561
Other names: ATCC 27638, Acuformis perennis, BCRC 14541, C. baratii, CCRC 14541, CCRC:14541, CCUG 24033, CIP 104306, Clostridium barati, Clostridium paraperfringens, Clostridium perenne, DSM 601, Inflabilis barati
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