STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
trpBTryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (400 aa)    
Predicted Functional Partners:
pabB
pabB: aminodeoxychorismate synthase, component I; [EH] COG0147 Anthranilate/para-aminobenzoate synthases component I.
 
  
 0.973
AQM60074.1
trpG_papA: glutamine amidotransferase of anthranilate synthase/aminodeoxychorismate synthase family protein; [EH] COG0512 Anthranilate/para-aminobenzoate synthases component II.
 
  
 0.960
ilvA
Threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
  
0.935
glyA
Beta-eliminating lyase family protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.919
sdaAB
Sda_beta: L-serine dehydratase, iron-sulfur-dependent, beta subunit; [E] COG1760 L-serine deaminase.
     
  0.900
sdaAA
Sda_alpha: L-serine dehydratase, iron-sulfur-dependent, alpha subunit; [E] COG1760 L-serine deaminase.
     
  0.900
pssA
pssA: CDP-diacylglycerol-serine O-phosphatidyltransferase; [I] COG1183 Phosphatidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
     
  0.900
AQM61038.1
glyoxalase/Bleomycin resistance /Dioxygenase superfamily protein; [E] COG0346 Lactoylglutathione lyase and related lyases.
   
  0.821
metA
Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family.
    
  0.817
cysE
cysE: serine O-acetyltransferase; [E] COG1045 Serine acetyltransferase.
     
 0.815
Your Current Organism:
Clostridium baratii
NCBI taxonomy Id: 1561
Other names: ATCC 27638, Acuformis perennis, BCRC 14541, C. baratii, CCRC 14541, CCRC:14541, CCUG 24033, CIP 104306, Clostridium barati, Clostridium paraperfringens, Clostridium perenne, DSM 601, Inflabilis barati
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