STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
topBDNA topoisomerase III family protein; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus [...] (723 aa)    
Predicted Functional Partners:
recQ-2
recQ: ATP-dependent DNA helicase RecQ; [L] COG0514 Superfamily II DNA helicase.
 
 0.741
recQ
recQ: ATP-dependent DNA helicase RecQ; [L] COG0514 Superfamily II DNA helicase.
 
 0.734
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
  
 0.601
nifJ
Pyruvate:ferredoxin (flavodoxin) oxidoreductase; pyruv_ox_red: pyruvate:ferredoxin (flavodoxin) oxidoreductase; [C] COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit.
  
   0.590
NPD11_551
Putative ABC transporter ATP-binding protein HI_0664; [V] COG1132 ABC-type multidrug transport system, ATPase and permease components.
 
   
 0.544
NPD11_552
ABC transporter family protein; [CO] COG4988 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components.
 
     0.543
NPD11_550
Conserved hypothetical protein; [S] COG2832 Uncharacterized protein conserved in bacteria.
       0.512
NPD11_548
Iron Transport-associated domain protein.
       0.509
NPD11_549
Nitrous oxide-stimulated promoter family protein.
       0.496
ssb
Ssb: single-stranded DNA-binding family protein; [L] COG0629 Single-stranded DNA-binding protein.
  
 
 0.493
Your Current Organism:
Clostridium baratii
NCBI taxonomy Id: 1561
Other names: ATCC 27638, Acuformis perennis, BCRC 14541, C. baratii, CCRC 14541, CCRC:14541, CCUG 24033, CIP 104306, Clostridium barati, Clostridium paraperfringens, Clostridium perenne, DSM 601, Inflabilis barati
Server load: low (14%) [HD]