STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nadENAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (635 aa)    
Predicted Functional Partners:
nadD
Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
  
 
 0.978
nadK
ATP-NAD kinase family protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
    
 0.974
cobB-2
Sir2 family protein; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily.
  
 0.967
AQM60498.1
NUDIX domain protein; [L] COG2816 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding.
  
 
 0.911
AQM61043.1
Nicotinate phosphoribosyltransferase family protein; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.
  
  
 0.851
AQM61380.1
CM_mono_grmpos: chorismate mutase; [E] COG0077 Prephenate dehydratase.
  
  
 0.839
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
   
 
 0.783
NPD11_911
FGAM-synthase: phosphoribosylformylglycinamidine synthase; [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain.
  
  
 0.782
AQM60146.1
birA_ligase: biotin--[acetyl-CoA-carboxylase] ligase; [H] COG0340 Biotin-(acetyl-CoA carboxylase) ligase.
  
  
 0.780
cobA
cobA_cysG_Cterm: uroporphyrinogen-III C-methyltransferase; [H] COG0007 Uroporphyrinogen-III methylase.
  
  
 0.776
Your Current Organism:
Clostridium baratii
NCBI taxonomy Id: 1561
Other names: ATCC 27638, Acuformis perennis, BCRC 14541, C. baratii, CCRC 14541, CCRC:14541, CCUG 24033, CIP 104306, Clostridium barati, Clostridium paraperfringens, Clostridium perenne, DSM 601, Inflabilis barati
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