STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
glnD[Protein-PII] uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. (845 aa)    
Predicted Functional Partners:
OSS41647.1
Nitrogen regulatory protein P-II; Belongs to the P(II) protein family.
 
 
 0.949
OSS43064.1
Nitrogen regulatory protein P-II; Belongs to the P(II) protein family.
 
 
 0.949
OSS42193.1
Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...]
 
   
 0.806
OSS42919.1
3-deoxy-manno-octulosonate cytidylyltransferase; Belongs to the KdsB family.
       0.803
OSS42920.1
ADP-heptose synthase / D-glycero-beta-D-manno-heptose 7-phosphate kinase.
       0.803
OSS42921.1
Type 4 pilus assembly PilZ.
       0.803
OSS42925.1
YebC-like; FIG000859.
       0.777
OSS42923.1
2-haloalkanoic acid dehalogenase.
       0.773
OSS42924.1
Hypothetical protein.
       0.773
OSS42928.1
5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.
     
 0.716
Your Current Organism:
Desulfurella amilsii
NCBI taxonomy Id: 1562698
Other names: D. amilsii, DSM 29984, Desulfurella amilsii Florentino et al. 2016, Desulfurella sp. TR1, JCM 30680, strain TR1
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