EAS18778.1 protein (Flavobacteria bacterium BBFL7)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

EAS18778.1

Subtilisin-like protease. (1158 aa)

Predicted Functional Partners:

EAS19926.1

0.567

EAS20142.1

0.548

EAS18646.1

0.516

EAS21017.1

0.508

EAS20727.1

0.483

EAS19345.1

0.478

EAS20892.1

0.428

EAS21019.1

0.428

Your Current Organism:

Flavobacteria bacterium BBFL7

NCBI taxonomy Id: 156586
Other names: F. bacterium BBFL7, marine CFB-group bacterium BBFL7, marine bacterium BBFL7

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EAS18646.1	EAS18778.1	BBFL7_01090	BBFL7_00598	Putative NoeA host specific nodulation protein.	Subtilisin-like protease.	0.516
EAS18778.1	EAS18646.1	BBFL7_00598	BBFL7_01090	Subtilisin-like protease.	Putative NoeA host specific nodulation protein.	0.516
EAS18778.1	EAS19345.1	BBFL7_00598	BBFL7_00812	Subtilisin-like protease.	Putative DNA-directed RNA polymerase specialized sigma subunit; Belongs to the sigma-70 factor family. ECF subfamily.	0.478
EAS18778.1	EAS19926.1	BBFL7_00598	BBFL7_02326	Subtilisin-like protease.	Putative serine protease, subtilase family.	0.567
EAS18778.1	EAS20142.1	BBFL7_00598	BBFL7_02542	Subtilisin-like protease.	Conserved hypothetical protein.	0.548
EAS18778.1	EAS20727.1	BBFL7_00598	BBFL7_01617	Subtilisin-like protease.	Conserved hypothetical protein.	0.483
EAS18778.1	EAS20892.1	BBFL7_00598	BBFL7_01784	Subtilisin-like protease.	Hypothetical protein.	0.428
EAS18778.1	EAS21017.1	BBFL7_00598	BBFL7_01910	Subtilisin-like protease.	Putative lysyl endopeptidase precursor.	0.508
EAS18778.1	EAS21019.1	BBFL7_00598	BBFL7_01912	Subtilisin-like protease.	Hypothetical protein.	0.428
EAS19345.1	EAS18778.1	BBFL7_00812	BBFL7_00598	Putative DNA-directed RNA polymerase specialized sigma subunit; Belongs to the sigma-70 factor family. ECF subfamily.	Subtilisin-like protease.	0.478
EAS19926.1	EAS18778.1	BBFL7_02326	BBFL7_00598	Putative serine protease, subtilase family.	Subtilisin-like protease.	0.567
EAS19926.1	EAS21017.1	BBFL7_02326	BBFL7_01910	Putative serine protease, subtilase family.	Putative lysyl endopeptidase precursor.	0.443
EAS19926.1	EAS21019.1	BBFL7_02326	BBFL7_01912	Putative serine protease, subtilase family.	Hypothetical protein.	0.415
EAS20142.1	EAS18778.1	BBFL7_02542	BBFL7_00598	Conserved hypothetical protein.	Subtilisin-like protease.	0.548
EAS20142.1	EAS20892.1	BBFL7_02542	BBFL7_01784	Conserved hypothetical protein.	Hypothetical protein.	0.439
EAS20727.1	EAS18778.1	BBFL7_01617	BBFL7_00598	Conserved hypothetical protein.	Subtilisin-like protease.	0.483
EAS20892.1	EAS18778.1	BBFL7_01784	BBFL7_00598	Hypothetical protein.	Subtilisin-like protease.	0.428
EAS20892.1	EAS20142.1	BBFL7_01784	BBFL7_02542	Hypothetical protein.	Conserved hypothetical protein.	0.439
EAS21017.1	EAS18778.1	BBFL7_01910	BBFL7_00598	Putative lysyl endopeptidase precursor.	Subtilisin-like protease.	0.508
EAS21017.1	EAS19926.1	BBFL7_01910	BBFL7_02326	Putative lysyl endopeptidase precursor.	Putative serine protease, subtilase family.	0.443

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

26

average node degree:

4.73

avg. local clustering coefficient:

0.558

expected number of edges:

10

PPI enrichment p-value:

3.56e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045893

Positive regulation of transcription, DNA-templated

6 of 212

1.91

2.99

1.52e-07

GO:0045944

Positive regulation of transcription by RNA polymerase II

5 of 170

1.93

2.9

3.28e-07

GO:0006357

Regulation of transcription by RNA polymerase II

7 of 675

1.48

2.18

1.55e-07

GO:0006355

Regulation of transcription, DNA-templated

8 of 949

1.39

1.99

1.52e-07

GO:0010468

Regulation of gene expression

9 of 1607

1.21

1.6

1.52e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046982

Protein heterodimerization activity

5 of 46

2.5

4.35

3.28e-09

GO:0046983

Protein dimerization activity

6 of 112

2.19

4.13

1.71e-09

GO:0003700

DNA-binding transcription factor activity

5 of 404

1.56

1.7

6.14e-05

GO:0043565

Sequence-specific DNA binding

5 of 411

1.55

1.69

6.14e-05

GO:0000978

RNA polymerase II cis-regulatory region sequence-specific DNA binding

3 of 83

2.02

1.62

0.00064

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016602

CCAAT-binding factor complex

3 of 4

3.34

3.35

8.72e-07

GO:0005667

Transcription regulator complex

4 of 98

2.07

2.4

1.30e-05

GO:0140513

Nuclear protein-containing complex

5 of 894

1.21

1.03

0.0012

GO:0005634

Nucleus

9 of 4254

0.79

0.7

0.00016

GO:0032991

Protein-containing complex

6 of 3129

0.75

0.46

0.0242

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:24966

Mixed, incl. Homeobox, and Zinc finger, GATA-type

7 of 83

2.39

5.74

1.16e-12

CL:25072

Mixed, incl. Zinc finger, GATA-type, and Transcription factor CBF/NF-Y/archaeal histone domain

5 of 26

2.75

5.33

7.49e-11

CL:25102

Mixed, incl. CCAAT-binding factor complex, and CMG complex assembly

4 of 11

3.02

4.69

2.36e-09

CL:25105

CCAAT-binding factor complex, and CMG complex assembly

3 of 6

3.16

3.45

5.41e-07

CL:24973

Mixed, incl. Homeobox, and Fertilization

2 of 33

2.25

1.02

0.0127

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map05152

Tuberculosis

3 of 6

3.16

3.53

3.85e-07

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-381042

PERK regulates gene expression

3 of 6

3.16

3.09

2.44e-06

MAP-381033

ATF6 (ATF6-alpha) activates chaperones

3 of 10

2.94

4.15e-06

MAP-381119

Unfolded Protein Response (UPR)

3 of 60

2.16

1.77

0.00038

MAP-8957322

Metabolism of steroids

3 of 175

1.7

1.11

0.0052

MAP-212436

Generic Transcription Pathway

4 of 508

1.36

0.97

0.0047

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0539

Nucleus

7 of 432

1.67

2.91

6.69e-09

KW-0238

DNA-binding

3 of 202

1.63

1.09

0.0050

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00808

Histone-like transcription factor (CBF/NF-Y) and archaeal histone

4 of 8

3.16

4.55

4.91e-09

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003958

Transcription factor CBF/NF-Y/archaeal histone domain

4 of 8

3.16

4.49

6.46e-09

IPR009072

Histone-fold

5 of 38

2.58

4.31

5.48e-09

IPR027113

Transcription factor NFYB/HAP3

2 of 2

3.46

1.74

0.00074

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