EAS19413.1 protein (Flavobacteria bacterium BBFL7)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

EAS19413.1

Hypothetical protein. (162 aa)

Predicted Functional Partners:

EAS20466.1

0.753

EAS20969.1

0.736

EAS21123.1

0.653

EAS19756.1

0.631

EAS18641.1

0.630

EAS18698.1

0.593

EAS20077.1

0.591

EAS19481.1

0.586

EAS21085.1

0.570

EAS18826.1

0.550

Your Current Organism:

Flavobacteria bacterium BBFL7

NCBI taxonomy Id: 156586
Other names: F. bacterium BBFL7, marine CFB-group bacterium BBFL7, marine bacterium BBFL7

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EAS18641.1	EAS18698.1	BBFL7_01085	BBFL7_00961	Hypothetical protein.	Conserved hypothetical protein.	0.671
EAS18641.1	EAS18826.1	BBFL7_01085	BBFL7_00646	Hypothetical protein.	Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.	0.542
EAS18641.1	EAS19413.1	BBFL7_01085	BBFL7_00880	Hypothetical protein.	Hypothetical protein.	0.630
EAS18641.1	EAS19756.1	BBFL7_01085	BBFL7_00302	Hypothetical protein.	Conserved hypothetical protein.	0.558
EAS18641.1	EAS20466.1	BBFL7_01085	BBFL7_01354	Hypothetical protein.	Bacterial surface antigen family protein.	0.700
EAS18641.1	EAS20969.1	BBFL7_01085	BBFL7_01862	Hypothetical protein.	Conserved hypothetical protein.	0.680
EAS18641.1	EAS21085.1	BBFL7_01085	BBFL7_01978	Hypothetical protein.	Conserved hypothetical protein.	0.599
EAS18698.1	EAS18641.1	BBFL7_00961	BBFL7_01085	Conserved hypothetical protein.	Hypothetical protein.	0.671
EAS18698.1	EAS18826.1	BBFL7_00961	BBFL7_00646	Conserved hypothetical protein.	Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.	0.723
EAS18698.1	EAS19413.1	BBFL7_00961	BBFL7_00880	Conserved hypothetical protein.	Hypothetical protein.	0.593
EAS18698.1	EAS19481.1	BBFL7_00961	BBFL7_00026	Conserved hypothetical protein.	Response regulator.	0.454
EAS18698.1	EAS19756.1	BBFL7_00961	BBFL7_00302	Conserved hypothetical protein.	Conserved hypothetical protein.	0.654
EAS18698.1	EAS20466.1	BBFL7_00961	BBFL7_01354	Conserved hypothetical protein.	Bacterial surface antigen family protein.	0.734
EAS18698.1	EAS20969.1	BBFL7_00961	BBFL7_01862	Conserved hypothetical protein.	Conserved hypothetical protein.	0.569
EAS18826.1	EAS18641.1	BBFL7_00646	BBFL7_01085	Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.	Hypothetical protein.	0.542
EAS18826.1	EAS18698.1	BBFL7_00646	BBFL7_00961	Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.	Conserved hypothetical protein.	0.723
EAS18826.1	EAS19413.1	BBFL7_00646	BBFL7_00880	Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.	Hypothetical protein.	0.550
EAS18826.1	EAS19756.1	BBFL7_00646	BBFL7_00302	Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.	Conserved hypothetical protein.	0.623
EAS18826.1	EAS20466.1	BBFL7_00646	BBFL7_01354	Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.	Bacterial surface antigen family protein.	0.626
EAS18826.1	EAS20969.1	BBFL7_00646	BBFL7_01862	Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.	Conserved hypothetical protein.	0.686

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Network Stats

number of nodes:

11

number of edges:

47

average node degree:

8.55

avg. local clustering coefficient:

0.9

expected number of edges:

27

PPI enrichment p-value:

0.000307

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0050896

Response to stimulus

9 of 542

0.89

0.88

1.80e-05

GO:0050794

Regulation of cellular process

9 of 760

0.74

0.64

0.00021

GO:1901564

Organonitrogen compound metabolic process

9 of 1102

0.58

0.43

0.0041

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000155

Phosphorelay sensor kinase activity

8 of 120

1.49

2.37

1.74e-08

GO:0016740

Transferase activity

9 of 815

0.71

0.61

0.00026

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005886

Plasma membrane

8 of 922

0.6

0.42

0.0109

GO:0016021

Integral component of membrane

9 of 1190

0.54

0.39

0.0109

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4371

HPT domain superfamily, and PAS-associated, C-terminal

7 of 15

2.33

5.79

4.98e-13

CL:4355

HPT domain superfamily, and PAS domain

9 of 48

1.94

4.89

8.25e-14

CL:4358

HPT domain superfamily, and Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

8 of 43

1.93

4.59

1.09e-12

CL:4373

Histidine Phosphotransfer domain, and Sodium/solute symporter

5 of 10

2.36

4.32

2.07e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

9 of 602

0.84

0.8

2.75e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031965

Nuclear membrane

4 of 15

2.09

2.38

1.54e-05

GOCC:0016020

Membrane

9 of 1048

0.6

0.48

0.0012

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0597

Phosphoprotein

8 of 144

1.41

2.17

1.92e-08

KW-0418

Kinase

6 of 140

1.3

1.46

2.47e-05

KW-0175

Coiled coil

7 of 490

0.82

0.66

0.0015

KW-0808

Transferase

7 of 509

0.8

0.64

0.0015

KW-1133

Transmembrane helix

9 of 1096

0.58

0.45

0.0018

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR008207

Signal transduction histidine kinase, phosphotransfer (Hpt) domain

8 of 18

2.31

6.14

4.52e-14

IPR036641

HPT domain superfamily

8 of 19

2.29

6.08

4.52e-14

IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

7 of 65

1.7

2.89

1.39e-08

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

7 of 69

1.67

2.83

1.39e-08

IPR004358

Signal transduction histidine kinase-related protein, C-terminal

7 of 75

1.64

2.72

1.92e-08

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00073

Histidine Phosphotransfer domain

7 of 15

2.33

5.79

4.83e-13

SM00388

His Kinase A (phosphoacceptor) domain

8 of 73

1.7

3.48

3.48e-11

SM00387

Histidine kinase-like ATPases

7 of 84

1.59

2.71

5.46e-09

SM00448

cheY-homologous receiver domain

8 of 122

1.48

2.54

1.14e-09

SM01079

This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases PUBMED:11590000, PUBMED:11590001. Predicted to be a ligand binding domain PUBMED:11590000.

3 of 6

2.36

2.54

1.36e-05

(more ...)

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