EAS19872.1 protein (Flavobacteria bacterium BBFL7)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

EAS19872.1

Conserved hypothetical protein. (661 aa)

Predicted Functional Partners:

EAS18947.1

0.630

EAS20682.1

0.625

EAS18740.1

0.577

EAS19873.1

0.554

EAS19874.1

0.554

EAS18946.1

0.532

EAS18945.1

0.487

EAS19831.1

0.476

EAS20826.1

0.473

EAS19833.1

0.465

Your Current Organism:

Flavobacteria bacterium BBFL7

NCBI taxonomy Id: 156586
Other names: F. bacterium BBFL7, marine CFB-group bacterium BBFL7, marine bacterium BBFL7

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structured XML interaction data, according to the 'PSI-MI' data standard

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... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EAS18740.1	EAS18945.1	BBFL7_01003	BBFL7_00391	Hypothetical protein.	Conserved hypothetical protein.	0.658
EAS18740.1	EAS18946.1	BBFL7_01003	BBFL7_00392	Hypothetical protein.	Conserved hypothetical protein.	0.658
EAS18740.1	EAS18947.1	BBFL7_01003	BBFL7_00393	Hypothetical protein.	Hypothetical protein.	0.767
EAS18740.1	EAS19831.1	BBFL7_01003	BBFL7_02231	Hypothetical protein.	Conserved hypothetical protein.	0.636
EAS18740.1	EAS19833.1	BBFL7_01003	BBFL7_02233	Hypothetical protein.	Conserved hypothetical protein.	0.634
EAS18740.1	EAS19872.1	BBFL7_01003	BBFL7_02272	Hypothetical protein.	Conserved hypothetical protein.	0.577
EAS18740.1	EAS20682.1	BBFL7_01003	BBFL7_01572	Hypothetical protein.	Hypothetical protein.	0.722
EAS18740.1	EAS20826.1	BBFL7_01003	BBFL7_01717	Hypothetical protein.	Hypothetical protein.	0.479
EAS18945.1	EAS18740.1	BBFL7_00391	BBFL7_01003	Conserved hypothetical protein.	Hypothetical protein.	0.658
EAS18945.1	EAS18946.1	BBFL7_00391	BBFL7_00392	Conserved hypothetical protein.	Conserved hypothetical protein.	0.745
EAS18945.1	EAS18947.1	BBFL7_00391	BBFL7_00393	Conserved hypothetical protein.	Hypothetical protein.	0.662
EAS18945.1	EAS19872.1	BBFL7_00391	BBFL7_02272	Conserved hypothetical protein.	Conserved hypothetical protein.	0.487
EAS18945.1	EAS20682.1	BBFL7_00391	BBFL7_01572	Conserved hypothetical protein.	Hypothetical protein.	0.719
EAS18946.1	EAS18740.1	BBFL7_00392	BBFL7_01003	Conserved hypothetical protein.	Hypothetical protein.	0.658
EAS18946.1	EAS18945.1	BBFL7_00392	BBFL7_00391	Conserved hypothetical protein.	Conserved hypothetical protein.	0.745
EAS18946.1	EAS18947.1	BBFL7_00392	BBFL7_00393	Conserved hypothetical protein.	Hypothetical protein.	0.731
EAS18946.1	EAS19831.1	BBFL7_00392	BBFL7_02231	Conserved hypothetical protein.	Conserved hypothetical protein.	0.417
EAS18946.1	EAS19833.1	BBFL7_00392	BBFL7_02233	Conserved hypothetical protein.	Conserved hypothetical protein.	0.413
EAS18946.1	EAS19872.1	BBFL7_00392	BBFL7_02272	Conserved hypothetical protein.	Conserved hypothetical protein.	0.532
EAS18946.1	EAS20682.1	BBFL7_00392	BBFL7_01572	Conserved hypothetical protein.	Hypothetical protein.	0.689

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.879

expected number of edges:

14

PPI enrichment p-value:

5.11e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006351

Transcription, DNA-templated

6 of 12

1.81

2.66

5.30e-07

GO:0031564

Transcription antitermination

3 of 3

2.11

1.69

0.00052

GO:0006353

DNA-templated transcription, termination

3 of 3

2.11

1.69

0.00052

GO:0016070

RNA metabolic process

7 of 75

1.08

1.11

5.42e-05

GO:0010467

Gene expression

9 of 136

0.93

0.97

7.65e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003899

DNA-directed 5-3 RNA polymerase activity

3 of 4

1.99

1.31

0.0028

GO:0003676

Nucleic acid binding

8 of 177

0.77

0.59

0.0028

GO:0140098

Catalytic activity, acting on RNA

4 of 48

1.03

0.58

0.0311

GO:0003723

RNA binding

4 of 62

0.92

0.49

0.0476

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000428

DNA-directed RNA polymerase complex

3 of 5

1.89

1.38

0.0017

GO:0032991

Protein-containing complex

4 of 77

0.83

0.48

0.0351

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:220

RNA polymerase, and Transcription antitermination

5 of 5

2.11

3.01

5.81e-07

CL:138

Ribonucleoprotein

6 of 46

1.23

1.34

3.47e-05

CL:135

Ribonucleoprotein, and Translation regulator activity

7 of 65

1.15

1.24

2.14e-05

CL:1312

Mixed, incl. PUA-like superfamily, and Polyol metabolic process

2 of 5

1.72

0.89

0.0167

CL:121

Translation, and RNA metabolic process

8 of 135

0.89

0.86

3.72e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03020

RNA polymerase

3 of 3

2.11

1.68

0.00056

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9635486

Infection with Mycobacterium tuberculosis

3 of 23

1.23

0.78

0.0118

MAP-5663205

Infectious disease

3 of 24

1.21

0.77

0.0118

MAP-1643685

Disease

3 of 24

1.21

0.77

0.0118

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0240

DNA-directed RNA polymerase

3 of 4

1.99

1.57

0.00078

KW-0804

Transcription

5 of 22

1.47

1.56

9.16e-05

KW-0548

Nucleotidyltransferase

3 of 11

1.55

1.05

0.0052

KW-0889

Transcription antitermination

2 of 2

2.11

1.05

0.0107

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