STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rnhBRibonuclease HII, RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (199 aa)    
Predicted Functional Partners:
EAS21072.1
Lipid-A-disaccharide synthetase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
 
 
 0.938
EAS19210.1
DNA-directed DNA polymerase III beta chain dnaN; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required fo [...]
   
 
 0.912
EAS20871.1
Ribonuclease H, RNase H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
   
 
 0.779
EAS20031.1
Putative DNA topoisomerase I, eukaryotic-like.
    
 
 0.754
EAS19136.1
Phosphomannomutase/phosphoglucomutase.
      0.737
EAS19378.1
Putative ATP-dependent DNA helicase.
  
 
 0.726
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
   0.696
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 
 0.670
EAS18849.1
O-succinylbenzoic acid-CoA ligase.
    
   0.634
EAS19758.1
Putative signal peptidase; Belongs to the peptidase S26 family.
  
    0.622
Your Current Organism:
Flavobacteria bacterium BBFL7
NCBI taxonomy Id: 156586
Other names: F. bacterium BBFL7, marine CFB-group bacterium BBFL7, marine bacterium BBFL7
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.