| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KXB59945.1 | KXB62184.1 | HMPREF3180_02174 | HMPREF3180_01689 | Cytidine and deoxycytidylate deaminase zinc-binding region; KEGG: lba:Lebu_1485 2.9e-74 zinc-binding CMP/dCMP deaminase; K01493 dCMP deaminase; Psort location: Cytoplasmic, score: 8.96. | dTMP kinase; KEGG: lba:Lebu_1702 8.3e-102 thymidylate kinase; K00943 dTMP kinase; Psort location: Cytoplasmic, score: 8.96. | 0.921 |
| KXB59945.1 | KXB69568.1 | HMPREF3180_02174 | HMPREF3180_00307 | Cytidine and deoxycytidylate deaminase zinc-binding region; KEGG: lba:Lebu_1485 2.9e-74 zinc-binding CMP/dCMP deaminase; K01493 dCMP deaminase; Psort location: Cytoplasmic, score: 8.96. | KEGG: lba:Lebu_1965 1.7e-275 NAD pyrophosphatase/5'-nucleotidase NadN; K01081 5'-nucleotidase; Psort location: Periplasmic, score: 9.76; Belongs to the 5'-nucleotidase family. | 0.903 |
| KXB59945.1 | tdk | HMPREF3180_02174 | HMPREF3180_00033 | Cytidine and deoxycytidylate deaminase zinc-binding region; KEGG: lba:Lebu_1485 2.9e-74 zinc-binding CMP/dCMP deaminase; K01493 dCMP deaminase; Psort location: Cytoplasmic, score: 8.96. | Thymidine kinase; KEGG: lba:Lebu_1391 1.4e-179 thymidine kinase; K00857 thymidine kinase; Psort location: Cytoplasmic, score: 9.97. | 0.927 |
| KXB59945.1 | thyA | HMPREF3180_02174 | HMPREF3180_00250 | Cytidine and deoxycytidylate deaminase zinc-binding region; KEGG: lba:Lebu_1485 2.9e-74 zinc-binding CMP/dCMP deaminase; K01493 dCMP deaminase; Psort location: Cytoplasmic, score: 8.96. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.929 |
| KXB59965.1 | KXB69568.1 | HMPREF3180_02194 | HMPREF3180_00307 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | KEGG: lba:Lebu_1965 1.7e-275 NAD pyrophosphatase/5'-nucleotidase NadN; K01081 5'-nucleotidase; Psort location: Periplasmic, score: 9.76; Belongs to the 5'-nucleotidase family. | 0.905 |
| KXB59965.1 | Pdp | HMPREF3180_02194 | HMPREF3180_01228 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | KEGG: lba:Lebu_0788 4.3e-192 pyrimidine-nucleoside phosphorylase; K00756 pyrimidine-nucleoside phosphorylase; Psort location: Cytoplasmic, score: 8.96. | 0.967 |
| KXB59965.1 | tdk | HMPREF3180_02194 | HMPREF3180_00033 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | Thymidine kinase; KEGG: lba:Lebu_1391 1.4e-179 thymidine kinase; K00857 thymidine kinase; Psort location: Cytoplasmic, score: 9.97. | 0.933 |
| KXB59965.1 | udk | HMPREF3180_02194 | HMPREF3180_01154 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | Uridine kinase; KEGG: lba:Lebu_1122 1.9e-102 uridine kinase; K00876 uridine kinase; Psort location: Cytoplasmic, score: 9.97. | 0.919 |
| KXB62184.1 | KXB59945.1 | HMPREF3180_01689 | HMPREF3180_02174 | dTMP kinase; KEGG: lba:Lebu_1702 8.3e-102 thymidylate kinase; K00943 dTMP kinase; Psort location: Cytoplasmic, score: 8.96. | Cytidine and deoxycytidylate deaminase zinc-binding region; KEGG: lba:Lebu_1485 2.9e-74 zinc-binding CMP/dCMP deaminase; K01493 dCMP deaminase; Psort location: Cytoplasmic, score: 8.96. | 0.921 |
| KXB62184.1 | KXB69568.1 | HMPREF3180_01689 | HMPREF3180_00307 | dTMP kinase; KEGG: lba:Lebu_1702 8.3e-102 thymidylate kinase; K00943 dTMP kinase; Psort location: Cytoplasmic, score: 8.96. | KEGG: lba:Lebu_1965 1.7e-275 NAD pyrophosphatase/5'-nucleotidase NadN; K01081 5'-nucleotidase; Psort location: Periplasmic, score: 9.76; Belongs to the 5'-nucleotidase family. | 0.912 |
| KXB62184.1 | tdk | HMPREF3180_01689 | HMPREF3180_00033 | dTMP kinase; KEGG: lba:Lebu_1702 8.3e-102 thymidylate kinase; K00943 dTMP kinase; Psort location: Cytoplasmic, score: 8.96. | Thymidine kinase; KEGG: lba:Lebu_1391 1.4e-179 thymidine kinase; K00857 thymidine kinase; Psort location: Cytoplasmic, score: 9.97. | 0.937 |
| KXB62184.1 | thyA | HMPREF3180_01689 | HMPREF3180_00250 | dTMP kinase; KEGG: lba:Lebu_1702 8.3e-102 thymidylate kinase; K00943 dTMP kinase; Psort location: Cytoplasmic, score: 8.96. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.941 |
| KXB69568.1 | KXB59945.1 | HMPREF3180_00307 | HMPREF3180_02174 | KEGG: lba:Lebu_1965 1.7e-275 NAD pyrophosphatase/5'-nucleotidase NadN; K01081 5'-nucleotidase; Psort location: Periplasmic, score: 9.76; Belongs to the 5'-nucleotidase family. | Cytidine and deoxycytidylate deaminase zinc-binding region; KEGG: lba:Lebu_1485 2.9e-74 zinc-binding CMP/dCMP deaminase; K01493 dCMP deaminase; Psort location: Cytoplasmic, score: 8.96. | 0.903 |
| KXB69568.1 | KXB59965.1 | HMPREF3180_00307 | HMPREF3180_02194 | KEGG: lba:Lebu_1965 1.7e-275 NAD pyrophosphatase/5'-nucleotidase NadN; K01081 5'-nucleotidase; Psort location: Periplasmic, score: 9.76; Belongs to the 5'-nucleotidase family. | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | 0.905 |
| KXB69568.1 | KXB62184.1 | HMPREF3180_00307 | HMPREF3180_01689 | KEGG: lba:Lebu_1965 1.7e-275 NAD pyrophosphatase/5'-nucleotidase NadN; K01081 5'-nucleotidase; Psort location: Periplasmic, score: 9.76; Belongs to the 5'-nucleotidase family. | dTMP kinase; KEGG: lba:Lebu_1702 8.3e-102 thymidylate kinase; K00943 dTMP kinase; Psort location: Cytoplasmic, score: 8.96. | 0.912 |
| KXB69568.1 | Pdp | HMPREF3180_00307 | HMPREF3180_01228 | KEGG: lba:Lebu_1965 1.7e-275 NAD pyrophosphatase/5'-nucleotidase NadN; K01081 5'-nucleotidase; Psort location: Periplasmic, score: 9.76; Belongs to the 5'-nucleotidase family. | KEGG: lba:Lebu_0788 4.3e-192 pyrimidine-nucleoside phosphorylase; K00756 pyrimidine-nucleoside phosphorylase; Psort location: Cytoplasmic, score: 8.96. | 0.902 |
| KXB69568.1 | tdk | HMPREF3180_00307 | HMPREF3180_00033 | KEGG: lba:Lebu_1965 1.7e-275 NAD pyrophosphatase/5'-nucleotidase NadN; K01081 5'-nucleotidase; Psort location: Periplasmic, score: 9.76; Belongs to the 5'-nucleotidase family. | Thymidine kinase; KEGG: lba:Lebu_1391 1.4e-179 thymidine kinase; K00857 thymidine kinase; Psort location: Cytoplasmic, score: 9.97. | 0.919 |
| KXB69568.1 | thyA | HMPREF3180_00307 | HMPREF3180_00250 | KEGG: lba:Lebu_1965 1.7e-275 NAD pyrophosphatase/5'-nucleotidase NadN; K01081 5'-nucleotidase; Psort location: Periplasmic, score: 9.76; Belongs to the 5'-nucleotidase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.902 |
| KXB69568.1 | udk | HMPREF3180_00307 | HMPREF3180_01154 | KEGG: lba:Lebu_1965 1.7e-275 NAD pyrophosphatase/5'-nucleotidase NadN; K01081 5'-nucleotidase; Psort location: Periplasmic, score: 9.76; Belongs to the 5'-nucleotidase family. | Uridine kinase; KEGG: lba:Lebu_1122 1.9e-102 uridine kinase; K00876 uridine kinase; Psort location: Cytoplasmic, score: 9.97. | 0.916 |
| PcrA | tdk | HMPREF3180_00034 | HMPREF3180_00033 | KEGG: lba:Lebu_1390 0. UvrD/REP helicase; K03657 DNA helicase II / ATP-dependent DNA helicase PcrA; Psort location: Cytoplasmic, score: 9.97. | Thymidine kinase; KEGG: lba:Lebu_1391 1.4e-179 thymidine kinase; K00857 thymidine kinase; Psort location: Cytoplasmic, score: 9.97. | 0.720 |