Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PdxKKEGG: lba:Lebu_0489 9.7e-131 phosphomethylpyrimidine kinase; K00868 pyridoxine kinase. (287 aa)    
Predicted Functional Partners:
MetF
KEGG: lba:Lebu_0488 1.3e-144 5,10-methylenetetrahydrofolate reductase; K00297 methylenetetrahydrofolate reductase (NADPH); Psort location: Cytoplasmic, score: 9.97.
       0.773
thiI
Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
     
 0.510
KXB69986.1
Putative cysteine desulfurase; KEGG: lba:Lebu_1862 3.3e-169 class V aminotransferase; K04487 cysteine desulfurase; Psort location: Cytoplasmic, score: 9.97.
     
 0.447
KXB68803.1
KEGG: lba:Lebu_1602 1.8e-271 DEAD/DEAH box helicase; K05592 ATP-dependent RNA helicase DeaD; Psort location: Cytoplasmic, score: 9.97.
 
 
    0.444
KXB61704.1
Hypothetical protein; KEGG: stk:STP_1439 1.6e-08 truA; tRNA pseudouridine synthase A; K06173 tRNA pseudouridine38-40 synthase; Psort location: Cytoplasmic, score: 8.96.
  
    0.436
truA
tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
  
    0.436
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
     
 0.411
guaA
GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP.
 
   
 0.411
Your Current Organism:
Leptotrichia wadei
NCBI taxonomy Id: 157687
Other names: CCUG 47505, CIP 107918, DSM 19758, JCM 16777, L. wadei, Leptotrichia sp. LB16, Leptotrichia wadei Eribe et al. 2004, strain LB 16
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