Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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tgttRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] (393 aa)    
Predicted Functional Partners:
queA
S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
 
 
 0.971
truB
tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
  
  
 0.549
KXB59925.1
Rod shape-determining protein MreC; Involved in formation and maintenance of cell shape.
  
  
 0.542
KXB69566.1
KEGG: lba:Lebu_1963 7.7e-257 5'-nucleotidase domain-containing protein; K01119 2',3'-cyclic-nucleotide 2'-phosphodiesterase; Belongs to the 5'-nucleotidase family.
  
    0.530
KXB69567.1
MazG nucleotide pyrophosphohydrolase domain protein; KEGG: sng:SNE_A10590 0.00020 dctpp1; dCTP pyrophosphatase 1; Psort location: Cytoplasmic, score: 8.96.
       0.524
aspS
aspartate--tRNA ligase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
 
    0.514
secD
Export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
  
  
 0.474
KXB68313.1
Preprotein translocase, YajC subunit.
  
  
 0.460
hisS
histidine--tRNA ligase; KEGG: lba:Lebu_1869 4.4e-190 histidyl-tRNA synthetase; K01892 histidyl-tRNA synthetase; Psort location: Cytoplasmic, score: 10.00.
  
  
 0.432
KXB61408.1
KEGG: lba:Lebu_1538 0. phosphoribosylformylglycinamidine synthase; K01952 phosphoribosylformylglycinamidine synthase; Psort location: Cytoplasmic, score: 9.94.
  
    0.418
Your Current Organism:
Leptotrichia wadei
NCBI taxonomy Id: 157687
Other names: CCUG 47505, CIP 107918, DSM 19758, JCM 16777, L. wadei, Leptotrichia sp. LB16, Leptotrichia wadei Eribe et al. 2004, strain LB 16
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