| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KXB64394.1 | grpE | HMPREF3180_01421 | HMPREF3180_02351 | S4 domain protein; KEGG: wvi:Weevi_0511 3.4e-06 pseudouridine synthase; K06180 23S rRNA pseudouridine1911/1915/1917 synthase. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.448 |
| KXB64394.1 | hslO | HMPREF3180_01421 | HMPREF3180_00426 | S4 domain protein; KEGG: wvi:Weevi_0511 3.4e-06 pseudouridine synthase; K06180 23S rRNA pseudouridine1911/1915/1917 synthase. | Chaperonin HslO; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. | 0.591 |
| KXB69076.1 | hslO | HMPREF3180_00533 | HMPREF3180_00426 | Ribosome biogenesis GTP-binding protein YlqF; Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily. | Chaperonin HslO; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. | 0.517 |
| KXB69252.1 | ddl | HMPREF3180_00423 | HMPREF3180_00425 | Hypothetical protein; KEGG: hce:HCW_08465 7.8e-05 type I restriction enzyme R protein; K01153 type I restriction enzyme, R subunit; Psort location: Cytoplasmic, score: 8.96. | D-ala D-ala ligase protein; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | 0.480 |
| KXB69252.1 | hslO | HMPREF3180_00423 | HMPREF3180_00426 | Hypothetical protein; KEGG: hce:HCW_08465 7.8e-05 type I restriction enzyme R protein; K01153 type I restriction enzyme, R subunit; Psort location: Cytoplasmic, score: 8.96. | Chaperonin HslO; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. | 0.455 |
| KXB69252.1 | luxS | HMPREF3180_00423 | HMPREF3180_00424 | Hypothetical protein; KEGG: hce:HCW_08465 7.8e-05 type I restriction enzyme R protein; K01153 type I restriction enzyme, R subunit; Psort location: Cytoplasmic, score: 8.96. | S-ribosylhomocysteinase LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | 0.618 |
| KXB69580.1 | grpE | HMPREF3180_00320 | HMPREF3180_02351 | Hypothetical protein; KEGG: pfh:PFHG_04159 1.8e-14 hypothetical protein; K10592 E3 ubiquitin-protein ligase HUWE1; Psort location: OuterMembrane, score: 9.49. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.448 |
| KXB69580.1 | hslO | HMPREF3180_00320 | HMPREF3180_00426 | Hypothetical protein; KEGG: pfh:PFHG_04159 1.8e-14 hypothetical protein; K10592 E3 ubiquitin-protein ligase HUWE1; Psort location: OuterMembrane, score: 9.49. | Chaperonin HslO; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. | 0.591 |
| ddl | KXB69252.1 | HMPREF3180_00425 | HMPREF3180_00423 | D-ala D-ala ligase protein; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | Hypothetical protein; KEGG: hce:HCW_08465 7.8e-05 type I restriction enzyme R protein; K01153 type I restriction enzyme, R subunit; Psort location: Cytoplasmic, score: 8.96. | 0.480 |
| ddl | hslO | HMPREF3180_00425 | HMPREF3180_00426 | D-ala D-ala ligase protein; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | Chaperonin HslO; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. | 0.749 |
| ddl | luxS | HMPREF3180_00425 | HMPREF3180_00424 | D-ala D-ala ligase protein; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | S-ribosylhomocysteinase LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | 0.626 |
| ftsH | groL | HMPREF3180_00624 | HMPREF3180_00650 | ATP-dependent metallopeptidase HflB; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.500 |
| ftsH | grpE | HMPREF3180_00624 | HMPREF3180_02351 | ATP-dependent metallopeptidase HflB; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.422 |
| ftsH | hslO | HMPREF3180_00624 | HMPREF3180_00426 | ATP-dependent metallopeptidase HflB; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | Chaperonin HslO; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. | 0.455 |
| ftsH | lon | HMPREF3180_00624 | HMPREF3180_01830 | ATP-dependent metallopeptidase HflB; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | Endopeptidase La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.720 |
| groL | ftsH | HMPREF3180_00650 | HMPREF3180_00624 | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | ATP-dependent metallopeptidase HflB; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.500 |
| groL | grpE | HMPREF3180_00650 | HMPREF3180_02351 | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.964 |
| groL | hslO | HMPREF3180_00650 | HMPREF3180_00426 | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | Chaperonin HslO; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. | 0.473 |
| groL | lon | HMPREF3180_00650 | HMPREF3180_01830 | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | Endopeptidase La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.917 |
| grpE | KXB64394.1 | HMPREF3180_02351 | HMPREF3180_01421 | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | S4 domain protein; KEGG: wvi:Weevi_0511 3.4e-06 pseudouridine synthase; K06180 23S rRNA pseudouridine1911/1915/1917 synthase. | 0.448 |
