Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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[Homology]
Score
KXB68830.1HAD hydrolase, family IB; KEGG: ctc:CTC00969 1.4e-69 phosphoserine phosphatase; Psort location: Cytoplasmic, score: 8.96. (246 aa)    
Predicted Functional Partners:
hisI
KEGG: lba:Lebu_1219 8.4e-109 phosphoribosyl-ATP diphosphatase; K11755 phosphoribosyl-ATP pyrophosphohydrolase / phosphoribosyl-AMP cyclohydrolase; Psort location: Cytoplasmic, score: 9.97; In the N-terminal section; belongs to the PRA-CH family.
  
  
 0.907
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
  
  
 0.686
KXB68305.1
Hypothetical protein; Psort location: Cytoplasmic, score: 8.96.
  
     0.633
hisF
Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
  
  
 0.591
hisB
KEGG: lba:Lebu_1232 3.6e-101 imidazoleglycerol-phosphate dehydratase; K01693 imidazoleglycerol-phosphate dehydratase; Psort location: Cytoplasmic, score: 9.97.
  
  
 0.543
hisH
Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
  
  
 0.537
hisA
KEGG: lba:Lebu_1225 2.8e-117 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; K01814 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Psort location: Cytoplasmic, score: 9.97.
  
  
 0.520
KXB68831.1
KEGG: fnu:FN0965 7.0e-89 D-3-phosphoglycerate dehydrogenase K00058; Psort location: Cytoplasmic, score: 9.97; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
  
 
 0.509
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
  
 0.498
hisC
KEGG: lba:Lebu_1235 5.8e-165 histidinol-phosphate aminotransferase; K00817 histidinol-phosphate aminotransferase; Psort location: Cytoplasmic, score: 9.97; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
  
  
 0.440
Your Current Organism:
Leptotrichia wadei
NCBI taxonomy Id: 157687
Other names: CCUG 47505, CIP 107918, DSM 19758, JCM 16777, L. wadei, Leptotrichia sp. LB16, Leptotrichia wadei Eribe et al. 2004, strain LB 16
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