Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (210 aa)    
Predicted Functional Partners:
hisI
KEGG: lba:Lebu_1219 8.4e-109 phosphoribosyl-ATP diphosphatase; K11755 phosphoribosyl-ATP pyrophosphohydrolase / phosphoribosyl-AMP cyclohydrolase; Psort location: Cytoplasmic, score: 9.97; In the N-terminal section; belongs to the PRA-CH family.
 
 
 0.999
KXB64675.1
Hypothetical protein; KEGG: ova:OBV_41970 1.5e-38 ATP phosphoribosyltransferase regulatory subunit/ATP phosphoribosyltransferase K00765; Psort location: Cytoplasmic, score: 9.97.
 0.999
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
 
  
 0.998
hisF
Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
  
 0.997
hisH
Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
  
 0.997
hisB
KEGG: lba:Lebu_1232 3.6e-101 imidazoleglycerol-phosphate dehydratase; K01693 imidazoleglycerol-phosphate dehydratase; Psort location: Cytoplasmic, score: 9.97.
 
  
 0.997
hisA
KEGG: lba:Lebu_1225 2.8e-117 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; K01814 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Psort location: Cytoplasmic, score: 9.97.
 
  
 0.996
hisC
KEGG: lba:Lebu_1235 5.8e-165 histidinol-phosphate aminotransferase; K00817 histidinol-phosphate aminotransferase; Psort location: Cytoplasmic, score: 9.97; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
 
  
 0.983
KXB60911.1
Aminotransferase, class I/II; KEGG: lba:Lebu_0041 1.8e-186 threonine-phosphate decarboxylase; K04720 threonine-phosphate decarboxylase; Psort location: Cytoplasmic, score: 9.97.
  
  
 0.975
hisS
histidine--tRNA ligase; KEGG: lba:Lebu_1869 4.4e-190 histidyl-tRNA synthetase; K01892 histidyl-tRNA synthetase; Psort location: Cytoplasmic, score: 10.00.
 
 
 0.897
Your Current Organism:
Leptotrichia wadei
NCBI taxonomy Id: 157687
Other names: CCUG 47505, CIP 107918, DSM 19758, JCM 16777, L. wadei, Leptotrichia sp. LB16, Leptotrichia wadei Eribe et al. 2004, strain LB 16
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.