Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
KXB60883.1KEGG: lba:Lebu_0028 7.0e-247 uroporphyrin-III C-methyltransferase; K13542 uroporphyrinogen III methyltransferase / synthase; Psort location: Cytoplasmic, score: 9.97. (496 aa)    
Predicted Functional Partners:
hemC
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 0.999
KXB63126.1
Siroheme synthase domain protein; KEGG: lba:Lebu_1979 2.8e-62 ferrochelatase; K02304 precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase; Psort location: Cytoplasmic, score: 9.97.
 
 
 0.993
KXB63127.1
Porphobilinogen synthase; KEGG: lba:Lebu_1980 1.1e-161 delta-aminolevulinic acid dehydratase; K01698 porphobilinogen synthase; Psort location: Cytoplasmic, score: 9.97; Belongs to the ALAD family.
 
 
 0.991
hemA
glutamyl-tRNAGlu reductase domain protein; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.980
KXB60713.1
KEGG: lba:Lebu_0100 2.5e-107 precorrin-2 C(20)-methyltransferase; K03394 precorrin-2/cobalt-factor-2 C20-methyltransferase; Psort location: Cytoplasmic, score: 9.97.
 
 
 0.949
KXB64529.1
Nitrite/sulfite reductase ferredoxin domain protein; KEGG: lba:Lebu_0372 8.8e-288 nitrite and sulfite reductase 4Fe-4S region; K00381 sulfite reductase (NADPH) hemoprotein beta-component; Psort location: Cytoplasmic, score: 9.97.
 
  
 0.933
hemL
Glutamate-1-semialdehyde-2,1-aminomutase; KEGG: lba:Lebu_0559 1.6e-208 glutamate-1-semialdehyde aminotransferase; K01845 glutamate-1-semialdehyde 2,1-aminomutase; Psort location: Cytoplasmic, score: 9.97.
 
  
 0.822
KXB64525.1
KEGG: lba:Lebu_0376 1.0e-158 sulfate adenylyltransferase subunit 2; K00957 sulfate adenylyltransferase subunit 2; Psort location: Cytoplasmic, score: 9.97.
  
  
 0.718
KXB60720.1
KEGG: lba:Lebu_0108 2.6e-121 precorrin-4 C(11)-methyltransferase; K05936 precorrin-4 C11-methyltransferase; Psort location: Cytoplasmic, score: 9.97.
 
  
0.579
cbiD
Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
 
  
 0.558
Your Current Organism:
Leptotrichia wadei
NCBI taxonomy Id: 157687
Other names: CCUG 47505, CIP 107918, DSM 19758, JCM 16777, L. wadei, Leptotrichia sp. LB16, Leptotrichia wadei Eribe et al. 2004, strain LB 16
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