Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
KXB59945.1Cytidine and deoxycytidylate deaminase zinc-binding region; KEGG: lba:Lebu_1485 2.9e-74 zinc-binding CMP/dCMP deaminase; K01493 dCMP deaminase; Psort location: Cytoplasmic, score: 8.96. (171 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.929
tdk
Thymidine kinase; KEGG: lba:Lebu_1391 1.4e-179 thymidine kinase; K00857 thymidine kinase; Psort location: Cytoplasmic, score: 9.97.
 
 
 0.927
KXB62184.1
dTMP kinase; KEGG: lba:Lebu_1702 8.3e-102 thymidylate kinase; K00943 dTMP kinase; Psort location: Cytoplasmic, score: 8.96.
    
 0.921
KXB69568.1
KEGG: lba:Lebu_1965 1.7e-275 NAD pyrophosphatase/5'-nucleotidase NadN; K01081 5'-nucleotidase; Psort location: Periplasmic, score: 9.76; Belongs to the 5'-nucleotidase family.
  
 
  0.903
cmk
Cytidylate kinase; KEGG: lba:Lebu_0694 4.2e-91 cytidylate kinase; K00945 cytidylate kinase; Psort location: Cytoplasmic, score: 9.97.
    
  0.901
xseA
Exodeoxyribonuclease VII, large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family.
       0.805
KXB59943.1
Hypothetical protein.
       0.524
KXB59946.1
Hypothetical protein; Psort location: CytoplasmicMembrane, score: 10.00.
       0.516
KXB69239.1
Putative Xaa-Pro dipeptidase; KEGG: smf:Smon_1224 1.8e-90 peptidase M24; K01262 Xaa-Pro aminopeptidase; Psort location: Cytoplasmic, score: 9.97.
  
  
 0.440
ribBA
3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
     
 0.421
Your Current Organism:
Leptotrichia wadei
NCBI taxonomy Id: 157687
Other names: CCUG 47505, CIP 107918, DSM 19758, JCM 16777, L. wadei, Leptotrichia sp. LB16, Leptotrichia wadei Eribe et al. 2004, strain LB 16
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