Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
KXB59404.1KEGG: crn:CAR_c12470 1.5e-56 aldose-1-epimerase. (293 aa)    
Predicted Functional Partners:
KXB59405.1
Hypothetical protein.
       0.675
KXB64691.1
KEGG: lba:Lebu_0589 3.7e-289 PTS system lactose-specific transporter subunit IIC; K02787 PTS system, lactose-specific IIB component K02788; Psort location: CytoplasmicMembrane, score: 10.00.
  
  
 0.576
KXB59406.1
Hypothetical protein; KEGG: edi:EDI_043330 0.0017 polyamine-modulated factor 1-binding protein; Psort location: Cytoplasmic, score: 8.96.
       0.511
grpE
Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...]
     
 0.475
KXB59403.1
Hypothetical protein; Psort location: CytoplasmicMembrane, score: 10.00.
       0.456
KXB64693.1
Tagatose-bisphosphate aldolase; KEGG: lba:Lebu_0587 3.8e-161 tagatose 1,6-diphosphate aldolase; K01635 tagatose 1,6-diphosphate aldolase; Psort location: Cytoplasmic, score: 8.96.
  
  
 0.455
KXB64689.1
KEGG: hor:Hore_04250 1.0e-41 LacI family transcriptional regulator; Psort location: Cytoplasmic, score: 9.94.
 
   
 0.447
dnaJ
Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
       0.426
hrcA
Transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.
     
 0.404
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
     
 0.402
Your Current Organism:
Leptotrichia wadei
NCBI taxonomy Id: 157687
Other names: CCUG 47505, CIP 107918, DSM 19758, JCM 16777, L. wadei, Leptotrichia sp. LB16, Leptotrichia wadei Eribe et al. 2004, strain LB 16
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