STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SDB84115.1DNA gyrase subunit B. (691 aa)    
Predicted Functional Partners:
SDB84103.1
DNA topoisomerase IV subunit A.
 
 0.998
gyrA
DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
 
 0.997
SDB91780.1
DNA topoisomerase IB.
   
 
 0.948
recA
Recombination protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.767
SDB85918.1
ATP-dependent DNA helicase, Rep family.
  
 
 0.764
SDB85255.1
Glutamate synthase (NADH) large subunit.
     
 0.758
dnaK
Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 
 0.738
rpoB
DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
  
 0.736
SDB86813.1
Hypothetical protein.
    
 
 0.674
SDB88857.1
Pentapeptide repeat-containing protein.
    
 
 0.674
Your Current Organism:
Raineyella antarctica
NCBI taxonomy Id: 1577474
Other names: ATCC TSD-18, DSM 100494, JCM 30886, Propionibacteriaceae bacterium 10J, Propionibacteriaceae bacterium LZ-22, R. antarctica, Raineyella antarctica Pikuta et al. 2016, strain LZ-22
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.