STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
glnEGlutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] (931 aa)    
Predicted Functional Partners:
SDQ64494.1
Glutamate synthase (NADH) large subunit.
    
 0.896
glnD
UTP--GlnB (protein PII) uridylyltransferase, GlnD; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.
 
   
 0.829
SDQ32939.1
L-glutamine synthetase.
 
   
 0.784
SDR44473.1
Glutamine synthetase.
 
   
 0.750
SDQ90495.1
TIGR02099 family protein; Manually curated.
 
     0.661
SDQ64461.1
Glutamate synthase (NADH) small subunit.
     
 0.581
SDR59788.1
Glutamate synthase (NADPH/NADH) small chain.
     
 0.581
SDQ33185.1
ATP-dependent helicase HrpA.
  
     0.562
SDQ90447.1
Nitrilase.
 
   
 0.549
argA
N-acetylglutamate synthase; Belongs to the acetyltransferase family. ArgA subfamily.
     
 0.516
Your Current Organism:
Paraburkholderia tuberum
NCBI taxonomy Id: 157910
Other names: Burkholderia sp. WSM4174, Burkholderia sp. WSM4175, Burkholderia sp. WSM4176, Burkholderia sp. WSM4177, Burkholderia sp. WSM4179, Burkholderia sp. WSM4180, Burkholderia tuberum, Burkholderia tuberum Vandamme et al. 2003, CCUG 47178, CIP 108238, DSM 18489, LMG 21444, LMG:21444, P. tuberum, Paraburkholderia tuberum (Vandamme et al. 2003) Sawana et al. 2015, strain STM678
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.