AJF61643.1 protein (archaeon GW2011AR15) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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Textmining

[Homology]

Score

AJF61643.1

Hypothetical protein. (196 aa)

Predicted Functional Partners:

AJF61641.1

0.705

AJF61642.1

0.705

AJF61644.1

0.532

Your Current Organism:

archaeon GW2011AR15

NCBI taxonomy Id: 1579373
Other names: a. GW2011_AR15, archaeon GW2011_AR15

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AJF61641.1	AJF61642.1	QT06_C0001G0806	QT06_C0001G0807	Hypothetical protein.	Hypothetical protein.	0.773
AJF61641.1	AJF61643.1	QT06_C0001G0806	QT06_C0001G0808	Hypothetical protein.	Hypothetical protein.	0.705
AJF61641.1	AJF61644.1	QT06_C0001G0806	QT06_C0001G0809	Hypothetical protein.	Hypothetical protein.	0.490
AJF61642.1	AJF61641.1	QT06_C0001G0807	QT06_C0001G0806	Hypothetical protein.	Hypothetical protein.	0.773
AJF61642.1	AJF61643.1	QT06_C0001G0807	QT06_C0001G0808	Hypothetical protein.	Hypothetical protein.	0.705
AJF61642.1	AJF61644.1	QT06_C0001G0807	QT06_C0001G0809	Hypothetical protein.	Hypothetical protein.	0.490
AJF61643.1	AJF61641.1	QT06_C0001G0808	QT06_C0001G0806	Hypothetical protein.	Hypothetical protein.	0.705
AJF61643.1	AJF61642.1	QT06_C0001G0808	QT06_C0001G0807	Hypothetical protein.	Hypothetical protein.	0.705
AJF61643.1	AJF61644.1	QT06_C0001G0808	QT06_C0001G0809	Hypothetical protein.	Hypothetical protein.	0.532
AJF61644.1	AJF61641.1	QT06_C0001G0809	QT06_C0001G0806	Hypothetical protein.	Hypothetical protein.	0.490
AJF61644.1	AJF61642.1	QT06_C0001G0809	QT06_C0001G0807	Hypothetical protein.	Hypothetical protein.	0.490
AJF61644.1	AJF61643.1	QT06_C0001G0809	QT06_C0001G0808	Hypothetical protein.	Hypothetical protein.	0.532

Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.91

expected number of edges:

12

PPI enrichment p-value:

3.14e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019318

Hexose metabolic process

8 of 45

2.2

5.59

2.34e-13

GO:0006006

Glucose metabolic process

6 of 25

2.33

4.67

2.59e-10

GO:0006096

Glycolytic process

5 of 21

2.33

3.81

2.31e-08

GO:0006094

Gluconeogenesis

3 of 12

2.35

2.26

4.89e-05

GO:0006091

Generation of precursor metabolites and energy

6 of 144

1.57

2.22

7.90e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019200

Carbohydrate kinase activity

4 of 18

2.3

2.59

9.51e-06

GO:0048029

Monosaccharide binding

3 of 13

2.31

1.77

0.00045

GO:0008443

Phosphofructokinase activity

2 of 5

2.55

1.1

0.0097

GO:0008865

Fructokinase activity

2 of 6

2.47

1.09

0.0099

GO:0005536

Glucose binding

2 of 6

2.47

1.09

0.0099

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005829

Cytosol

8 of 821

0.94

0.85

0.00026

GO:0005737

Cytoplasm

11 of 4126

0.38

0.28

0.0294

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:11825

Glycolysis, and Pentose phosphate pathway

9 of 51

2.2

6.69

1.11e-16

CL:11821

Pentose phosphate pathway, and Glycolysis

10 of 79

2.05

6.23

3.22e-17

CL:11819

Carbohydrate metabolic process, and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein

11 of 153

1.81

5.0

3.22e-17

CL:11905

Carbohydrate phosphorylation, and Mannose-6-phosphate isomerase

4 of 11

2.51

3.49

2.11e-07

CL:11829

Pentose phosphate pathway, and Glycolytic process

5 of 37

2.08

3.28

1.04e-07

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00030

Pentose phosphate pathway

6 of 35

2.19

4.63

8.22e-11

map00051

Fructose and mannose metabolism

7 of 58

2.03

4.51

1.93e-11

map00010

Glycolysis / Gluconeogenesis

7 of 79

1.9

3.98

7.39e-11

map01200

Carbon metabolism

7 of 188

1.52

2.48

1.26e-08

map00052

Galactose metabolism

4 of 50

1.85

2.34

6.59e-06

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-70171

Glycolysis

5 of 27

2.22

3.54

5.50e-08

MAP-70326

Glucose metabolism

6 of 135

1.6

2.24

1.04e-06

MAP-71387

Metabolism of carbohydrates

8 of 263

1.43

2.18

4.21e-08

MAP-170822

Regulation of Glucokinase by Glucokinase Regulatory Protein

2 of 5

2.55

1.29

0.0044

MAP-6798695

Neutrophil degranulation

5 of 299

1.17

0.92

0.0025

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0324

Glycolysis

5 of 14

2.5

4.5

1.66e-09

KW-0119

Carbohydrate metabolism

2 of 21

1.93

0.78

0.0340

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03727

Hexokinase

2 of 6

2.47

0.83

0.0303

PF00349

Hexokinase

2 of 6

2.47

0.83

0.0303

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