STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (427 aa)    
Predicted Functional Partners:
AKS41903.1
Pfam:pfam08328 Adenylosuccinate lyase C-terminal; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
 0.997
guaB
Inosine 5''''-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
 
 
 0.988
purH
Bifunctional purine biosynthesis protein PurH; Pfam:pfam01808 AICARFT/IMPCHase bienzyme.
  
 0.974
purL
Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
  
  
 0.966
pyrB
Pfam:pfam02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
 
 
 0.949
AKS41726.1
Phosphoribosyltransferase; Pfam:pfam00156 Phosphoribosyl transferase domain.
  
 
 0.942
AKS40574.1
Pfam:pfam00764 Arginosuccinate synthase.
  
 
 0.935
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
 
  
 0.928
surE
Stationary phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.915
AKS42744.1
Hypothetical protein; Pfam:pfam13537 Glutamine amidotransferase domain.
  
 
 0.915
Your Current Organism:
Wenzhouxiangella marina
NCBI taxonomy Id: 1579979
Other names: CGMCC 1.14936, Chromatiales bacterium Ma-11, KCTC 42284, MCCC 1K00261, W. marina, Wenzhouxiangella marina Wang et al. 2015, strain Ma-11
Server load: low (8%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.