node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKS42617.1 | AKS42964.1 | WM2015_2254 | WM2015_2606 | Vi polysaccharide biosynthesis protein VipA/TviB; Pfam:pfam03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. | Hypothetical protein; Pfam:pfam02350 UDP-N-acetylglucosamine 2-epimerase. | 0.984 |
AKS42617.1 | glmU | WM2015_2254 | WM2015_2581 | Vi polysaccharide biosynthesis protein VipA/TviB; Pfam:pfam03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. | Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | 0.926 |
AKS42617.1 | lpxA | WM2015_2254 | WM2015_430 | Vi polysaccharide biosynthesis protein VipA/TviB; Pfam:pfam03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. | Acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.821 |
AKS42617.1 | murA | WM2015_2254 | WM2015_643 | Vi polysaccharide biosynthesis protein VipA/TviB; Pfam:pfam03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.904 |
AKS42820.1 | glmU | WM2015_2459 | WM2015_2581 | Pfam:pfam01636 Phosphotransferase enzyme family. | Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | 0.915 |
AKS42964.1 | AKS42617.1 | WM2015_2606 | WM2015_2254 | Hypothetical protein; Pfam:pfam02350 UDP-N-acetylglucosamine 2-epimerase. | Vi polysaccharide biosynthesis protein VipA/TviB; Pfam:pfam03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. | 0.984 |
AKS42964.1 | glmU | WM2015_2606 | WM2015_2581 | Hypothetical protein; Pfam:pfam02350 UDP-N-acetylglucosamine 2-epimerase. | Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | 0.932 |
AKS42964.1 | lpxA | WM2015_2606 | WM2015_430 | Hypothetical protein; Pfam:pfam02350 UDP-N-acetylglucosamine 2-epimerase. | Acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.815 |
AKS42964.1 | murA | WM2015_2606 | WM2015_643 | Hypothetical protein; Pfam:pfam02350 UDP-N-acetylglucosamine 2-epimerase. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.910 |
glmM | glmS | WM2015_1742 | WM2015_2982 | Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | Glutamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | 0.958 |
glmM | glmU | WM2015_1742 | WM2015_2581 | Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | 0.992 |
glmM | murA | WM2015_1742 | WM2015_643 | Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.651 |
glmM | murC | WM2015_1742 | WM2015_2364 | Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.648 |
glmM | murE | WM2015_1742 | WM2015_2369 | Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.405 |
glmS | glmM | WM2015_2982 | WM2015_1742 | Glutamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | 0.958 |
glmS | glmU | WM2015_2982 | WM2015_2581 | Glutamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | 0.953 |
glmS | murE | WM2015_2982 | WM2015_2369 | Glutamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.486 |
glmU | AKS42617.1 | WM2015_2581 | WM2015_2254 | Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | Vi polysaccharide biosynthesis protein VipA/TviB; Pfam:pfam03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. | 0.926 |
glmU | AKS42820.1 | WM2015_2581 | WM2015_2459 | Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | Pfam:pfam01636 Phosphotransferase enzyme family. | 0.915 |
glmU | AKS42964.1 | WM2015_2581 | WM2015_2606 | Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | Hypothetical protein; Pfam:pfam02350 UDP-N-acetylglucosamine 2-epimerase. | 0.932 |