STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (816 aa)    
Predicted Functional Partners:
AKS40685.1
ATP-dependent DNA helicase RecQ; Pfam:pfam09382 RQC domain.
 0.990
AKS41164.1
ERCC4 domain protein.
    
 0.948
AKS40699.1
Smf protein; Pfam:pfam02481 DNA recombination-mediator protein A.
   
 0.945
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
 0.854
recA
Protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.843
AKS40779.1
Exodeoxyribonuclease IX; Pfam:pfam02739 5'-3' exonuclease, N-terminal resolvase-like domain.
 
 0.831
AKS40923.1
Metallophosphoesterase; Pfam:pfam00149 Calcineurin-like phosphoesterase.
  
 0.794
AKS42387.1
Single-stranded DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
  
 
 0.777
AKS41948.1
Pfam:pfam13177 DNA polymerase III, delta subunit.
 
 0.769
smg
Pfam:pfam04361 Protein of unknown function (DUF494); Belongs to the Smg family.
 
   
 0.754
Your Current Organism:
Wenzhouxiangella marina
NCBI taxonomy Id: 1579979
Other names: CGMCC 1.14936, Chromatiales bacterium Ma-11, KCTC 42284, MCCC 1K00261, W. marina, Wenzhouxiangella marina Wang et al. 2015, strain Ma-11
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.