AKS41214.1 protein (Wenzhouxiangella marina)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

AKS41214.1

Hypothetical protein. (891 aa)

Predicted Functional Partners:

AKS41213.1

0.773

AKS40604.1

0.763

AKS41979.1

0.752

AKS41980.1

0.745

AKS41434.1

0.727

AKS42488.1

0.721

WM2015_75

0.717

AKS42857.1

0.714

AKS41829.1

0.711

AKS42970.1

0.711

Your Current Organism:

Wenzhouxiangella marina

NCBI taxonomy Id: 1579979
Other names: CGMCC 1.14936, Chromatiales bacterium Ma-11, KCTC 42284, MCCC 1K00261, W. marina, Wenzhouxiangella marina Wang et al. 2015, strain Ma-11

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKS40604.1	AKS41214.1	WM2015_215	WM2015_833	Hypothetical protein.	Hypothetical protein.	0.763
AKS40604.1	AKS41434.1	WM2015_215	WM2015_1057	Hypothetical protein.	Hypothetical protein.	0.754
AKS40604.1	AKS41829.1	WM2015_215	WM2015_1457	Hypothetical protein.	Hypothetical protein.	0.761
AKS40604.1	AKS41979.1	WM2015_215	WM2015_1609	Hypothetical protein.	Hypothetical protein.	0.772
AKS40604.1	AKS41980.1	WM2015_215	WM2015_1610	Hypothetical protein.	Hypothetical protein.	0.772
AKS40604.1	AKS42488.1	WM2015_215	WM2015_2123	Hypothetical protein.	Hypothetical protein; Pfam:pfam10282 Lactonase, 7-bladed beta-propeller.	0.686
AKS40604.1	WM2015_75	WM2015_215	WM2015_75	Hypothetical protein.	Hypothetical protein; Pfam:pfam01345 Domain of unknown function DUF11.	0.613
AKS41213.1	AKS41214.1	WM2015_832	WM2015_833	Pfam:pfam12158 Protein of unknown function (DUF3592).	Hypothetical protein.	0.773
AKS41214.1	AKS40604.1	WM2015_833	WM2015_215	Hypothetical protein.	Hypothetical protein.	0.763
AKS41214.1	AKS41213.1	WM2015_833	WM2015_832	Hypothetical protein.	Pfam:pfam12158 Protein of unknown function (DUF3592).	0.773
AKS41214.1	AKS41434.1	WM2015_833	WM2015_1057	Hypothetical protein.	Hypothetical protein.	0.727
AKS41214.1	AKS41829.1	WM2015_833	WM2015_1457	Hypothetical protein.	Hypothetical protein.	0.711
AKS41214.1	AKS41979.1	WM2015_833	WM2015_1609	Hypothetical protein.	Hypothetical protein.	0.752
AKS41214.1	AKS41980.1	WM2015_833	WM2015_1610	Hypothetical protein.	Hypothetical protein.	0.745
AKS41214.1	AKS42488.1	WM2015_833	WM2015_2123	Hypothetical protein.	Hypothetical protein; Pfam:pfam10282 Lactonase, 7-bladed beta-propeller.	0.721
AKS41214.1	AKS42857.1	WM2015_833	WM2015_2499	Hypothetical protein.	Hypothetical protein.	0.714
AKS41214.1	AKS42970.1	WM2015_833	WM2015_2612	Hypothetical protein.	Hypothetical protein.	0.711
AKS41214.1	WM2015_75	WM2015_833	WM2015_75	Hypothetical protein.	Hypothetical protein; Pfam:pfam01345 Domain of unknown function DUF11.	0.717
AKS41434.1	AKS40604.1	WM2015_1057	WM2015_215	Hypothetical protein.	Hypothetical protein.	0.754
AKS41434.1	AKS41214.1	WM2015_1057	WM2015_833	Hypothetical protein.	Hypothetical protein.	0.727

page 1 of 4

Network Stats

number of nodes:

6

number of edges:

13

average node degree:

4.33

avg. local clustering coefficient:

0.9

expected number of edges:

5

PPI enrichment p-value:

0.00219

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031929

TOR signaling

4 of 8

2.74

3.32

6.66e-07

GO:0010506

Regulation of autophagy

4 of 16

2.44

2.88

3.25e-06

GO:0071230

Cellular response to amino acid stimulus

3 of 8

2.62

2.2

8.40e-05

GO:0007154

Cell communication

7 of 441

1.24

1.36

3.20e-05

GO:0035556

Intracellular signal transduction

5 of 215

1.41

1.34

0.00033

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0038201

TOR complex

4 of 7

2.8

3.76

1.02e-07

GO:0031931

TORC1 complex

3 of 4

2.92

2.78

8.18e-06

GO:0031932

TORC2 complex

3 of 5

2.82

2.75

8.72e-06

GO:1990131

Gtr1-Gtr2 GTPase complex

2 of 2

3.04

1.67

0.00094

GO:0019897

Extrinsic component of plasma membrane

2 of 9

2.39

1.33

0.0035

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3329

Amino acids regulate mTORC1, and Peptidyl-serine phosphorylation

7 of 25

2.49

6.16

3.13e-13

CL:3331

Regulation of TOR signaling, and TORC1 complex

5 of 13

2.63

4.7

9.75e-10

CL:3333

Response to amino acid

4 of 5

2.94

4.18

1.99e-08

CL:3363

TORC2 complex, and snRNA catabolic process

2 of 5

2.64

1.24

0.0056

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04136

Autophagy - other

4 of 30

2.17

2.77

2.59e-06

map04138

Autophagy - yeast

4 of 113

1.59

1.57

0.00020

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9639288

Amino acids regulate mTORC1

6 of 35

2.28

4.49

4.40e-10

MAP-9711097

Cellular response to starvation

6 of 38

2.24

4.44

4.40e-10

MAP-6806003

Regulation of TP53 Expression and Degradation

4 of 10

2.64

3.68

1.15e-07

MAP-6804757

Regulation of TP53 Degradation

4 of 10

2.64

3.68

1.15e-07

MAP-389357

CD28 dependent PI3K/Akt signaling

3 of 5

2.82

2.92

4.18e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0038201

TOR complex

4 of 10

2.64

3.43

3.64e-07

GOCC:0031931

TORC1 complex

3 of 7

2.67

2.43

3.31e-05

GOCC:0031932

TORC2 complex

3 of 8

2.62

2.41

3.31e-05

GOCC:1990131

Gtr1-Gtr2 GTPase complex

2 of 2

3.04

1.64

0.0011

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR011989

Armadillo-like helical

4 of 88

1.7

1.21

0.0030

IPR006762

Gtr1/RagA G protein

2 of 2

3.04

1.2

0.0068

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