node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
OFT22297.1 | OFT23052.1 | HMPREF3175_09355 | HMPREF3175_06320 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. | Membrane protein insertase YidC; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.897 |
OFT22297.1 | OFT23829.1 | HMPREF3175_09355 | HMPREF3175_03080 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. | Preprotein translocase subunit SecG; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | 0.974 |
OFT22297.1 | OFT24235.1 | HMPREF3175_09355 | HMPREF3175_01755 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | 0.792 |
OFT22297.1 | ffh | HMPREF3175_09355 | HMPREF3175_01465 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. | Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | 0.971 |
OFT22297.1 | ftsY | HMPREF3175_09355 | HMPREF3175_01470 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. | Signal recognition particle-docking protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). | 0.974 |
OFT22297.1 | secA | HMPREF3175_09355 | HMPREF3175_02580 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. | Preprotein translocase subunit SecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | 0.976 |
OFT22297.1 | secD | HMPREF3175_09355 | HMPREF3175_09350 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. | Preprotein translocase subunit SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.984 |
OFT22297.1 | secE | HMPREF3175_09355 | HMPREF3175_00845 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. | Hypothetical protein; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. | 0.985 |
OFT22297.1 | secF | HMPREF3175_09355 | HMPREF3175_09345 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. | Preprotein translocase subunit SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.929 |
OFT22297.1 | secY | HMPREF3175_09355 | HMPREF3175_04185 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. | Preprotein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.955 |
OFT23052.1 | OFT22297.1 | HMPREF3175_06320 | HMPREF3175_09355 | Membrane protein insertase YidC; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. | 0.897 |
OFT23052.1 | OFT23829.1 | HMPREF3175_06320 | HMPREF3175_03080 | Membrane protein insertase YidC; Derived by automated computational analysis using gene prediction method: Protein Homology. | Preprotein translocase subunit SecG; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | 0.982 |
OFT23052.1 | ffh | HMPREF3175_06320 | HMPREF3175_01465 | Membrane protein insertase YidC; Derived by automated computational analysis using gene prediction method: Protein Homology. | Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | 0.943 |
OFT23052.1 | ftsY | HMPREF3175_06320 | HMPREF3175_01470 | Membrane protein insertase YidC; Derived by automated computational analysis using gene prediction method: Protein Homology. | Signal recognition particle-docking protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). | 0.923 |
OFT23052.1 | secA | HMPREF3175_06320 | HMPREF3175_02580 | Membrane protein insertase YidC; Derived by automated computational analysis using gene prediction method: Protein Homology. | Preprotein translocase subunit SecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | 0.946 |
OFT23052.1 | secD | HMPREF3175_06320 | HMPREF3175_09350 | Membrane protein insertase YidC; Derived by automated computational analysis using gene prediction method: Protein Homology. | Preprotein translocase subunit SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.959 |
OFT23052.1 | secE | HMPREF3175_06320 | HMPREF3175_00845 | Membrane protein insertase YidC; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. | 0.979 |
OFT23052.1 | secF | HMPREF3175_06320 | HMPREF3175_09345 | Membrane protein insertase YidC; Derived by automated computational analysis using gene prediction method: Protein Homology. | Preprotein translocase subunit SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.946 |
OFT23052.1 | secY | HMPREF3175_06320 | HMPREF3175_04185 | Membrane protein insertase YidC; Derived by automated computational analysis using gene prediction method: Protein Homology. | Preprotein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.992 |
OFT23829.1 | OFT22297.1 | HMPREF3175_03080 | HMPREF3175_09355 | Preprotein translocase subunit SecG; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. | 0.974 |