STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADY11885.1KEGG: pmz:HMPREF0659_A5807 L-serine ammonia-lyase; PFAM: Serine dehydratase-like, alpha subunit; Serine dehydratase beta chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. (402 aa)    
Predicted Functional Partners:
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.958
ADY12714.1
KEGG: sta:STHERM_c21790 hypothetical protein; TIGRFAM: Phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; PFAM: Haloacid dehalogenase-like hydrolase.
   
 
 0.913
ADY13806.1
KEGG: ssm:Spirs_1684 serine O-acetyltransferase.
     
 0.913
trpB
Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
     
  0.900
ADY13536.1
TIGRFAM: Aspartate kinase domain; KEGG: ssm:Spirs_2770 aspartate kinase; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; Aspartate/glutamate/uridylate kinase; Amino acid-binding ACT.
  
 
 0.855
metAA
Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family.
     
 0.824
ADY12335.1
PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: cdl:CDR20291_0970 lactoylglutathione lyase.
   
 
  0.801
ADY12576.1
PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: ere:EUBREC_1411 lactoylglutathione lyase related lyase.
   
 
  0.801
ADY13857.1
PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: glyoxalase/bleomycin resistance protein/dioxygenase.
   
 
  0.801
ADY13635.1
PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: amt:Amet_1529 glyoxalase/bleomycin resistance protein/dioxygenase.
     
  0.800
Your Current Organism:
Sphaerochaeta globosa
NCBI taxonomy Id: 158189
Other names: S. globosa str. Buddy, Sphaerochaeta globosa str. Buddy, Sphaerochaeta sp. Buddy, Spirochaeta sp. Buddy
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