node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADY11880.1 | ADY12710.1 | SpiBuddy_0034 | SpiBuddy_0883 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Nicotinate-nucleotide/dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.478 |
ADY11880.1 | ADY12712.1 | SpiBuddy_0034 | SpiBuddy_0885 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Adenosylcobinamide-phosphate guanylyltransferase; KEGG: cte:CT0945 cobalamin biosynthesis protein CobP; PFAM: Cobinamide kinase/cobinamide phosphate guanyltransferase. | 0.529 |
ADY11880.1 | ADY12714.1 | SpiBuddy_0034 | SpiBuddy_0887 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | KEGG: sta:STHERM_c21790 hypothetical protein; TIGRFAM: Phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; PFAM: Haloacid dehalogenase-like hydrolase. | 0.837 |
ADY11880.1 | ADY13782.1 | SpiBuddy_0034 | SpiBuddy_1959 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; PFAM: Adenosylcobalamin biosynthesis, ATP:cob(I)alamin adenosyltransferase CobA/CobO/ButR; KEGG: rrs:RoseRS_0557 cob(I)alamin adenosyltransferase. | 0.539 |
ADY11880.1 | cobS | SpiBuddy_0034 | SpiBuddy_0886 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.521 |
ADY12709.1 | ADY12710.1 | SpiBuddy_0882 | SpiBuddy_0883 | PFAM: Protein of unknown function DUF606; KEGG: cpy:Cphy_1299 hypothetical protein. | Nicotinate-nucleotide/dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.563 |
ADY12709.1 | ADY12711.1 | SpiBuddy_0882 | SpiBuddy_0884 | PFAM: Protein of unknown function DUF606; KEGG: cpy:Cphy_1299 hypothetical protein. | PFAM: Xylose isomerase, TIM barrel domain; KEGG: dal:Dalk_0459 xylose isomerase domain protein TIM barrel. | 0.563 |
ADY12709.1 | ADY12712.1 | SpiBuddy_0882 | SpiBuddy_0885 | PFAM: Protein of unknown function DUF606; KEGG: cpy:Cphy_1299 hypothetical protein. | Adenosylcobinamide-phosphate guanylyltransferase; KEGG: cte:CT0945 cobalamin biosynthesis protein CobP; PFAM: Cobinamide kinase/cobinamide phosphate guanyltransferase. | 0.532 |
ADY12709.1 | ADY12714.1 | SpiBuddy_0882 | SpiBuddy_0887 | PFAM: Protein of unknown function DUF606; KEGG: cpy:Cphy_1299 hypothetical protein. | KEGG: sta:STHERM_c21790 hypothetical protein; TIGRFAM: Phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; PFAM: Haloacid dehalogenase-like hydrolase. | 0.435 |
ADY12709.1 | ADY12715.1 | SpiBuddy_0882 | SpiBuddy_0888 | PFAM: Protein of unknown function DUF606; KEGG: cpy:Cphy_1299 hypothetical protein. | Hypothetical protein. | 0.435 |
ADY12709.1 | ADY12716.1 | SpiBuddy_0882 | SpiBuddy_0889 | PFAM: Protein of unknown function DUF606; KEGG: cpy:Cphy_1299 hypothetical protein. | PFAM: Protein of unknown function DUF62; KEGG: ssm:Spirs_3587 protein of unknown function DUF62. | 0.448 |
ADY12709.1 | cobS | SpiBuddy_0882 | SpiBuddy_0886 | PFAM: Protein of unknown function DUF606; KEGG: cpy:Cphy_1299 hypothetical protein. | Cobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.532 |
ADY12710.1 | ADY11880.1 | SpiBuddy_0883 | SpiBuddy_0034 | Nicotinate-nucleotide/dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.478 |
ADY12710.1 | ADY12709.1 | SpiBuddy_0883 | SpiBuddy_0882 | Nicotinate-nucleotide/dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | PFAM: Protein of unknown function DUF606; KEGG: cpy:Cphy_1299 hypothetical protein. | 0.563 |
ADY12710.1 | ADY12711.1 | SpiBuddy_0883 | SpiBuddy_0884 | Nicotinate-nucleotide/dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | PFAM: Xylose isomerase, TIM barrel domain; KEGG: dal:Dalk_0459 xylose isomerase domain protein TIM barrel. | 0.784 |
ADY12710.1 | ADY12712.1 | SpiBuddy_0883 | SpiBuddy_0885 | Nicotinate-nucleotide/dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | Adenosylcobinamide-phosphate guanylyltransferase; KEGG: cte:CT0945 cobalamin biosynthesis protein CobP; PFAM: Cobinamide kinase/cobinamide phosphate guanyltransferase. | 0.995 |
ADY12710.1 | ADY12714.1 | SpiBuddy_0883 | SpiBuddy_0887 | Nicotinate-nucleotide/dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | KEGG: sta:STHERM_c21790 hypothetical protein; TIGRFAM: Phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; PFAM: Haloacid dehalogenase-like hydrolase. | 0.603 |
ADY12710.1 | ADY12715.1 | SpiBuddy_0883 | SpiBuddy_0888 | Nicotinate-nucleotide/dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | Hypothetical protein. | 0.583 |
ADY12710.1 | ADY12716.1 | SpiBuddy_0883 | SpiBuddy_0889 | Nicotinate-nucleotide/dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | PFAM: Protein of unknown function DUF62; KEGG: ssm:Spirs_3587 protein of unknown function DUF62. | 0.583 |
ADY12710.1 | ADY12717.1 | SpiBuddy_0883 | SpiBuddy_0890 | Nicotinate-nucleotide/dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | PFAM: Protein of unknown function DUF1393; KEGG: ssm:Spirs_3589 protein of unknown function DUF1393. | 0.516 |