STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADY14555.1PFAM: Haloacid dehalogenase-like hydrolase. (245 aa)    
Predicted Functional Partners:
hisI
TIGRFAM: Phosphoribosyl-ATP pyrophosphohydrolase; HAMAP: Phosphoribosyl-ATP pyrophosphohydrolase; Histidine biosynthesis bifunctional protein HisIE; KEGG: sli:Slin_5481 phosphoribosyl-ATP diphosphatase; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase-like; Phosphoribosyl-AMP cyclohydrolase; In the N-terminal section; belongs to the PRA-CH family.
  
  
 0.906
hisB
PFAM: Imidazoleglycerol-phosphate dehydratase; TIGRFAM: Histidinol-phosphatase; Histidinol-phosphate phosphatase; HAD-superfamily hydrolase, subfamily IIIA; HAMAP: Imidazoleglycerol-phosphate dehydratase; KEGG: chu:CHU_1270 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
  
  
 0.678
hisF
Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
  
  
 0.678
ADY14554.1
PHP domain protein; KEGG: cpy:Cphy_3026 phosphotransferase domain-containing protein; PFAM: PHP, C-terminal; SMART: Polymerase/histidinol phosphatase, N-terminal.
       0.621
hisH
Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
  
  
 0.612
hisA
1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; HAMAP: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: fjo:Fjoh_2873 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: Histidine biosynthesis.
  
  
 0.609
ADY14556.1
KEGG: cpy:Cphy_1318 MATE efflux family protein; TIGRFAM: Multi antimicrobial extrusion protein; PFAM: Multi antimicrobial extrusion protein.
       0.548
ADY14557.1
PFAM: KDPG/KHG aldolase; KEGG: 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase.
       0.491
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
  
 0.490
hisC
PFAM: Aminotransferase, class I/classII; TIGRFAM: Histidinol-phosphate aminotransferase; HAMAP: Histidinol-phosphate aminotransferase; KEGG: cpi:Cpin_1819 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
  
  
 0.478
Your Current Organism:
Sphaerochaeta globosa
NCBI taxonomy Id: 158189
Other names: S. globosa str. Buddy, Sphaerochaeta globosa str. Buddy, Sphaerochaeta sp. Buddy, Spirochaeta sp. Buddy
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