Fcan01_19148 protein (Folsomia candida) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

Fcan01_19148

Leucine-rich repeat-containing G-protein coupled receptor 4. (317 aa)

Predicted Functional Partners:

Fcan01_14388

0.815

Fcan01_03179

0.815

Fcan01_24717

0.640

Fcan01_04627

0.448

Fcan01_04628

0.448

Fcan01_05967

0.435

Fcan01_05965

0.435

Fcan01_22636

0.401

Your Current Organism:

Folsomia candida

NCBI taxonomy Id: 158441
Other names: F. candida

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Fcan01_03179	Fcan01_19148	A0A226EXC3	A0A226DMR2	Latrophilin-3; Belongs to the G-protein coupled receptor 2 family.	Leucine-rich repeat-containing G-protein coupled receptor 4.	0.815
Fcan01_04627	Fcan01_04628	A0A226ENX6	A0A226EPZ9	Peripheral plasma membrane protein CASK; Belongs to the MAGUK family.	Peripheral plasma membrane protein CASK.	0.990
Fcan01_04627	Fcan01_19148	A0A226ENX6	A0A226DMR2	Peripheral plasma membrane protein CASK; Belongs to the MAGUK family.	Leucine-rich repeat-containing G-protein coupled receptor 4.	0.448
Fcan01_04628	Fcan01_04627	A0A226EPZ9	A0A226ENX6	Peripheral plasma membrane protein CASK.	Peripheral plasma membrane protein CASK; Belongs to the MAGUK family.	0.990
Fcan01_04628	Fcan01_19148	A0A226EPZ9	A0A226DMR2	Peripheral plasma membrane protein CASK.	Leucine-rich repeat-containing G-protein coupled receptor 4.	0.448
Fcan01_05965	Fcan01_05967	A0A226ETZ8	A0A226ETY3	Inactive tyrosine-protein kinase 7.	Inactive tyrosine-protein kinase 7.	0.957
Fcan01_05965	Fcan01_19148	A0A226ETZ8	A0A226DMR2	Inactive tyrosine-protein kinase 7.	Leucine-rich repeat-containing G-protein coupled receptor 4.	0.435
Fcan01_05967	Fcan01_05965	A0A226ETY3	A0A226ETZ8	Inactive tyrosine-protein kinase 7.	Inactive tyrosine-protein kinase 7.	0.957
Fcan01_05967	Fcan01_19148	A0A226ETY3	A0A226DMR2	Inactive tyrosine-protein kinase 7.	Leucine-rich repeat-containing G-protein coupled receptor 4.	0.435
Fcan01_14388	Fcan01_19148	A0A226E0Z3	A0A226DMR2	Polysialoglycoprotein; Belongs to the G-protein coupled receptor 2 family.	Leucine-rich repeat-containing G-protein coupled receptor 4.	0.815
Fcan01_19148	Fcan01_03179	A0A226DMR2	A0A226EXC3	Leucine-rich repeat-containing G-protein coupled receptor 4.	Latrophilin-3; Belongs to the G-protein coupled receptor 2 family.	0.815
Fcan01_19148	Fcan01_04627	A0A226DMR2	A0A226ENX6	Leucine-rich repeat-containing G-protein coupled receptor 4.	Peripheral plasma membrane protein CASK; Belongs to the MAGUK family.	0.448
Fcan01_19148	Fcan01_04628	A0A226DMR2	A0A226EPZ9	Leucine-rich repeat-containing G-protein coupled receptor 4.	Peripheral plasma membrane protein CASK.	0.448
Fcan01_19148	Fcan01_05965	A0A226DMR2	A0A226ETZ8	Leucine-rich repeat-containing G-protein coupled receptor 4.	Inactive tyrosine-protein kinase 7.	0.435
Fcan01_19148	Fcan01_05967	A0A226DMR2	A0A226ETY3	Leucine-rich repeat-containing G-protein coupled receptor 4.	Inactive tyrosine-protein kinase 7.	0.435
Fcan01_19148	Fcan01_14388	A0A226DMR2	A0A226E0Z3	Leucine-rich repeat-containing G-protein coupled receptor 4.	Polysialoglycoprotein; Belongs to the G-protein coupled receptor 2 family.	0.815
Fcan01_19148	Fcan01_22636	A0A226DMR2	A0A226DAN1	Leucine-rich repeat-containing G-protein coupled receptor 4.	Small nuclear ribonucleoprotein Sm D2.	0.401
Fcan01_19148	Fcan01_24717	A0A226DMR2	A0A226D4I1	Leucine-rich repeat-containing G-protein coupled receptor 4.	Calcium homeostasis endoplasmic reticulum protein.	0.640
Fcan01_22636	Fcan01_19148	A0A226DAN1	A0A226DMR2	Small nuclear ribonucleoprotein Sm D2.	Leucine-rich repeat-containing G-protein coupled receptor 4.	0.401
Fcan01_22636	Fcan01_24717	A0A226DAN1	A0A226D4I1	Small nuclear ribonucleoprotein Sm D2.	Calcium homeostasis endoplasmic reticulum protein.	0.999

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Network Stats

number of nodes:

11

number of edges:

13

average node degree:

2.36

avg. local clustering coefficient:

0.885

expected number of edges:

10

PPI enrichment p-value:

0.233

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046907

Intracellular transport

5 of 521

1.35

0.95

0.0054

GO:0006886

Intracellular protein transport

4 of 319

1.46

0.92

0.0092

GO:0015031

Protein transport

5 of 823

1.15

0.74

0.0124

GO:0006606

Protein import into nucleus

2 of 40

2.06

0.74

0.0427

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043227

Membrane-bounded organelle

11 of 7441

0.54

0.43

0.0011

GO:0043229

Intracellular organelle

11 of 7650

0.52

0.42

0.0011

GO:0005737

Cytoplasm

10 of 6797

0.53

0.41

0.0031

GO:0043231

Intracellular membrane-bounded organelle

10 of 6999

0.52

0.4

0.0033

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3521

LAG1, DNA binding, and Protein of unknown function DUF6699

2 of 5

2.97

1.61

0.0012

CL:2008

Mixed, incl. Exportin-1/5, and Zinc finger, RanBP2-type

2 of 5

2.97

1.61

0.0012

CL:1954

Nuclear pore

3 of 32

2.34

1.58

0.0011

CL:15982

Mostly uncharacterized, incl. Serine-type endopeptidase activity, and Multifunctional anion exchangers

3 of 145

1.68

1.17

0.0035

CL:16106

Mixed, incl. Multifunctional anion exchangers, and Tyrosine/serine-protein phosphatase IphP-type

2 of 34

2.14

1.1

0.0085

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-68875

Mitotic Prophase

3 of 53

2.12

1.62

0.00076

MAP-68886

M Phase

4 of 175

1.72

1.47

0.00070

MAP-2980766

Nuclear Envelope Breakdown

2 of 26

2.25

0.92

0.0198

MAP-69278

Cell Cycle, Mitotic

4 of 630

1.17

0.66

0.0253

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR040159

Suppressor of hairless-like

2 of 2

3.37

1.39

0.0032

IPR037095

RBP-J/Cbf11, DNA binding domain superfamily

2 of 2

3.37

1.39

0.0032

IPR036358

Beta-trefoil domain superfamily

2 of 2

3.37

1.39

0.0032

IPR015351

RBP-J/Cbf11/Cbf12, DNA binding

2 of 2

3.37

1.39

0.0032

IPR015350

Beta-trefoil DNA-binding domain

2 of 2

3.37

1.39

0.0032

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01268

Beta-trefoil DNA-binding domain

2 of 2

3.37

1.93

0.00034

SM01267

LAG1, DNA binding

2 of 2

3.37

1.93

0.00034

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