STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Fcan01_14972Cuticle protein 8. (102 aa)    
Predicted Functional Partners:
Fcan01_05553
Fanconi anemia group M protein.
     
 0.740
Fcan01_12730
DNA replication ATP-dependent helicase/nuclease DNA2.
   
 
 0.697
Fcan01_13663
X-ray repair cross-complementing protein 6.
    
 
 0.661
Fen1
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]
   
 0.655
Fcan01_07802
BRCA1-associated RING domain protein 1.
    
 0.641
Fcan01_09449
DNA topoisomerase 3-alpha.
    
 0.625
Fcan01_03128
Non-specific serine/threonine protein kinase.
   
 
 0.600
Fcan01_22005
Replication factor A protein 1.
    
 0.572
Fcan01_00397
Replication protein A 70 kDa DNA-binding subunit.
    
 0.572
Fcan01_01956
Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
    
 0.572
Your Current Organism:
Folsomia candida
NCBI taxonomy Id: 158441
Other names: F. candida
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.