ENSBSLP00000004221 protein (Betta splendens)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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Textmining

[Homology]

Score

ENSBSLP00000004221

annotation not available (724 aa)

Predicted Functional Partners:

LOC114843270

0.543

ripk2

0.539

nek7

0.502

rfx5

0.486

sugt1

0.486

hsp90ab1

0.483

LOC114849323

0.483

LOC114848314

0.465

rps27a

0.460

LOC114859049

0.459

Your Current Organism:

Betta splendens

NCBI taxonomy Id: 158456
Other names: B. splendens, Siamese fighting fish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSBSLP00000004221	LOC114843270	ENSBSLP00000004221	ENSBSLP00000032838	annotation not available	Apoptosis-associated speck-like protein containing a CARD.	0.543
ENSBSLP00000004221	LOC114848314	ENSBSLP00000004221	ENSBSLP00000052438	annotation not available	Flocculation protein FLO11-like.	0.465
ENSBSLP00000004221	LOC114849323	ENSBSLP00000004221	ENSBSLP00000040470	annotation not available	Heat shock protein HSP 90-alpha 1.	0.483
ENSBSLP00000004221	LOC114859049	ENSBSLP00000004221	ENSBSLP00000018889	annotation not available	Uncharacterized LOC114859049.	0.459
ENSBSLP00000004221	hsp90ab1	ENSBSLP00000004221	ENSBSLP00000011377	annotation not available	Heat shock protein 90 alpha family class B member 1.	0.483
ENSBSLP00000004221	nek7	ENSBSLP00000004221	ENSBSLP00000055020	annotation not available	NIMA related kinase 7.	0.502
ENSBSLP00000004221	rfx5	ENSBSLP00000004221	ENSBSLP00000013184	annotation not available	Regulatory factor X5.	0.486
ENSBSLP00000004221	ripk2	ENSBSLP00000004221	ENSBSLP00000047387	annotation not available	Receptor interacting serine/threonine kinase 2.	0.539
ENSBSLP00000004221	rps27a	ENSBSLP00000004221	ENSBSLP00000033441	annotation not available	Ribosomal protein S27a.	0.460
ENSBSLP00000004221	sugt1	ENSBSLP00000004221	ENSBSLP00000037324	annotation not available	SGT1 homolog, MIS12 kinetochore complex assembly cochaperone.	0.486
LOC114843270	ENSBSLP00000004221	ENSBSLP00000032838	ENSBSLP00000004221	Apoptosis-associated speck-like protein containing a CARD.	annotation not available	0.543
LOC114843270	LOC114848314	ENSBSLP00000032838	ENSBSLP00000052438	Apoptosis-associated speck-like protein containing a CARD.	Flocculation protein FLO11-like.	0.441
LOC114843270	LOC114859049	ENSBSLP00000032838	ENSBSLP00000018889	Apoptosis-associated speck-like protein containing a CARD.	Uncharacterized LOC114859049.	0.918
LOC114843270	ripk2	ENSBSLP00000032838	ENSBSLP00000047387	Apoptosis-associated speck-like protein containing a CARD.	Receptor interacting serine/threonine kinase 2.	0.620
LOC114843270	rps27a	ENSBSLP00000032838	ENSBSLP00000033441	Apoptosis-associated speck-like protein containing a CARD.	Ribosomal protein S27a.	0.525
LOC114848314	ENSBSLP00000004221	ENSBSLP00000052438	ENSBSLP00000004221	Flocculation protein FLO11-like.	annotation not available	0.465
LOC114848314	LOC114843270	ENSBSLP00000052438	ENSBSLP00000032838	Flocculation protein FLO11-like.	Apoptosis-associated speck-like protein containing a CARD.	0.441
LOC114848314	ripk2	ENSBSLP00000052438	ENSBSLP00000047387	Flocculation protein FLO11-like.	Receptor interacting serine/threonine kinase 2.	0.667
LOC114848314	rps27a	ENSBSLP00000052438	ENSBSLP00000033441	Flocculation protein FLO11-like.	Ribosomal protein S27a.	0.920
LOC114849323	ENSBSLP00000004221	ENSBSLP00000040470	ENSBSLP00000004221	Heat shock protein HSP 90-alpha 1.	annotation not available	0.483

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.887

expected number of edges:

12

PPI enrichment p-value:

3.43e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006418

tRNA aminoacylation for protein translation

5 of 25

1.76

2.12

1.45e-05

GO:0006399

tRNA metabolic process

6 of 62

1.45

1.73

1.45e-05

GO:0034660

ncRNA metabolic process

7 of 88

1.36

1.67

6.24e-06

GO:0009070

Serine family amino acid biosynthetic process

3 of 10

1.94

1.61

0.00059

GO:0006520

Cellular amino acid metabolic process

7 of 141

1.16

1.27

2.03e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004812

aminoacyl-tRNA ligase activity

5 of 24

1.78

2.32

4.40e-06

GO:0140101

Catalytic activity, acting on a tRNA

6 of 48

1.56

2.01

4.40e-06

GO:0140098

Catalytic activity, acting on RNA

7 of 92

1.34

1.66

4.40e-06

GO:0062105

RNA 2-O-methyltransferase activity

2 of 4

2.16

1.04

0.0115

GO:0003723

RNA binding

4 of 100

1.06

0.65

0.0178

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005829

Cytosol

7 of 364

0.75

0.54

0.0054

GO:0005737

Cytoplasm

10 of 938

0.49

0.37

0.0054

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:386

Aminoacyl-tRNA biosynthesis, and GMP biosynthetic process

4 of 24

1.68

1.39

0.0010

CL:388

Aminoacyl-tRNA synthetase

3 of 12

1.86

1.18

0.0046

CL:392

Aminoacyl-tRNA synthetase, class Ia, anticodon-binding, and Histidine phosphatase superfamily

2 of 5

2.06

0.88

0.0222

CL:888

Cysteine metabolic process, and S-adenosylmethionine metabolic process

2 of 6

1.99

0.87

0.0227

CL:156

Translation, and Transcription, DNA-templated

5 of 139

1.02

0.65

0.0145

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00970

Aminoacyl-tRNA biosynthesis

5 of 30

1.68

2.15

6.06e-06

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005829

Cytosol

8 of 443

0.72

0.57

0.0014

GOCC:0005737

Cytoplasm

11 of 752

0.63

0.56

3.48e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0030

Aminoacyl-tRNA synthetase

5 of 23

1.8

2.38

3.25e-06

KW-0648

Protein biosynthesis

5 of 47

1.49

1.71

2.76e-05

KW-0963

Cytoplasm

8 of 226

1.01

1.07

1.03e-05

KW-0489

Methyltransferase

3 of 67

1.11

0.57

0.0431

KW-0862

Zinc

3 of 68

1.11

0.56

0.0431

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF09334

tRNA synthetases class I (M)

3 of 5

2.24

1.66

0.00071

PF00588

SpoU rRNA Methylase family

2 of 3

2.29

0.89

0.0227

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR009080

Aminoacyl-tRNA synthetase, class Ia, anticodon-binding

3 of 6

2.16

1.35

0.0028

IPR014729

Rossmann-like alpha/beta/alpha sandwich fold

4 of 31

1.57

1.16

0.0028

IPR001537

tRNA/rRNA methyltransferase, SpoU type

2 of 3

2.29

0.76

0.0396

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