LOC114850168 protein (Betta splendens) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

LOC114850168

Trace amine-associated receptor 13c-like. (328 aa)

Predicted Functional Partners:

nts

0.451

LOC114852773

0.447

haus8

0.445

LOC114851413

0.445

haus1

0.429

edn1

0.413

LOC114853974

0.409

gnal

0.409

LOC114855085

0.409

pomc

0.402

Your Current Organism:

Betta splendens

NCBI taxonomy Id: 158456
Other names: B. splendens, Siamese fighting fish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC114850168	LOC114851413	ENSBSLP00000004845	ENSBSLP00000017160	Trace amine-associated receptor 13c-like.	HAUS augmin-like complex subunit 3.	0.445
LOC114850168	LOC114852773	ENSBSLP00000004845	ENSBSLP00000045555	Trace amine-associated receptor 13c-like.	Prepronociceptin-like.	0.447
LOC114850168	LOC114853974	ENSBSLP00000004845	ENSBSLP00000024806	Trace amine-associated receptor 13c-like.	Guanine nucleotide-binding protein G(olf) subunit alpha-like.	0.409
LOC114850168	LOC114855085	ENSBSLP00000004845	ENSBSLP00000055023	Trace amine-associated receptor 13c-like.	Guanine nucleotide-binding protein G(s) subunit alpha-like.	0.409
LOC114850168	edn1	ENSBSLP00000004845	ENSBSLP00000046283	Trace amine-associated receptor 13c-like.	Endothelin 1.	0.413
LOC114850168	gnal	ENSBSLP00000004845	ENSBSLP00000052483	Trace amine-associated receptor 13c-like.	G protein subunit alpha L.	0.409
LOC114850168	haus1	ENSBSLP00000004845	ENSBSLP00000040917	Trace amine-associated receptor 13c-like.	HAUS augmin like complex subunit 1.	0.429
LOC114850168	haus8	ENSBSLP00000004845	ENSBSLP00000007409	Trace amine-associated receptor 13c-like.	HAUS augmin like complex subunit 8.	0.445
LOC114850168	nts	ENSBSLP00000004845	ENSBSLP00000033025	Trace amine-associated receptor 13c-like.	Neurotensin.	0.451
LOC114850168	pomc	ENSBSLP00000004845	ENSBSLP00000014980	Trace amine-associated receptor 13c-like.	Proopiomelanocortin.	0.402
LOC114851413	LOC114850168	ENSBSLP00000017160	ENSBSLP00000004845	HAUS augmin-like complex subunit 3.	Trace amine-associated receptor 13c-like.	0.445
LOC114851413	haus1	ENSBSLP00000017160	ENSBSLP00000040917	HAUS augmin-like complex subunit 3.	HAUS augmin like complex subunit 1.	0.998
LOC114851413	haus8	ENSBSLP00000017160	ENSBSLP00000007409	HAUS augmin-like complex subunit 3.	HAUS augmin like complex subunit 8.	0.997
LOC114852773	LOC114850168	ENSBSLP00000045555	ENSBSLP00000004845	Prepronociceptin-like.	Trace amine-associated receptor 13c-like.	0.447
LOC114852773	pomc	ENSBSLP00000045555	ENSBSLP00000014980	Prepronociceptin-like.	Proopiomelanocortin.	0.905
LOC114853974	LOC114850168	ENSBSLP00000024806	ENSBSLP00000004845	Guanine nucleotide-binding protein G(olf) subunit alpha-like.	Trace amine-associated receptor 13c-like.	0.409
LOC114853974	pomc	ENSBSLP00000024806	ENSBSLP00000014980	Guanine nucleotide-binding protein G(olf) subunit alpha-like.	Proopiomelanocortin.	0.749
LOC114855085	LOC114850168	ENSBSLP00000055023	ENSBSLP00000004845	Guanine nucleotide-binding protein G(s) subunit alpha-like.	Trace amine-associated receptor 13c-like.	0.409
LOC114855085	pomc	ENSBSLP00000055023	ENSBSLP00000014980	Guanine nucleotide-binding protein G(s) subunit alpha-like.	Proopiomelanocortin.	0.749
edn1	LOC114850168	ENSBSLP00000046283	ENSBSLP00000004845	Endothelin 1.	Trace amine-associated receptor 13c-like.	0.413

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.85

expected number of edges:

13

PPI enrichment p-value:

8.69e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006096

Glycolytic process

10 of 21

2.61

9.97

1.28e-21

GO:0019693

Ribose phosphate metabolic process

11 of 126

1.87

5.58

1.03e-18

GO:0006006

Glucose metabolic process

4 of 20

2.23

3.0

1.01e-06

GO:0005975

Carbohydrate metabolic process

11 of 363

1.41

2.75

5.19e-14

GO:0006094

Gluconeogenesis

3 of 9

2.45

2.47

2.12e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004332

Fructose-bisphosphate aldolase activity

4 of 6

2.75

3.48

3.37e-07

GO:0016861

Intramolecular oxidoreductase activity, interconverting aldoses and ketoses

3 of 11

2.36

1.93

0.00023

GO:0004807

Triose-phosphate isomerase activity

2 of 2

2.93

1.56

0.0015

GO:0016829

Lyase activity

5 of 177

1.38

1.31

0.00035

GO:0016853

Isomerase activity

4 of 98

1.54

1.29

0.0011

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10783

Glycolytic process, and Glucoamylase

10 of 18

2.67

10.54

1.79e-22

CL:10787

Glycolytic process

9 of 13

2.77

10.09

7.88e-21

CL:10790

Gluconeogenesis, and Glyceraldehyde/Erythrose phosphate dehydrogenase family

4 of 5

2.83

4.1

2.46e-08

CL:10803

Fructose-bisphosphate aldolase activity, and Tetratricopeptide repeat

3 of 5

2.71

2.67

1.15e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00010

Glycolysis / Gluconeogenesis

9 of 82

1.97

5.32

4.44e-15

map00680

Methane metabolism

5 of 39

2.04

3.41

3.19e-08

map01200

Carbon metabolism

9 of 192

1.6

3.29

3.41e-12

map01230

Biosynthesis of amino acids

8 of 230

1.47

2.49

1.26e-09

map00051

Fructose and mannose metabolism

4 of 70

1.68

1.96

2.52e-05

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-70171

Glycolysis

6 of 23

2.34

4.71

2.22e-10

MAP-70326

Glucose metabolism

6 of 107

1.68

2.43

5.68e-07

MAP-70263

Gluconeogenesis

5 of 91

1.67

2.02

1.42e-05

MAP-71387

Metabolism of carbohydrates

6 of 235

1.33

1.51

2.70e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0324

Glycolysis

5 of 13

2.51

4.51

1.63e-09

KW-0312

Gluconeogenesis

3 of 3

2.93

3.02

2.97e-06

KW-0413

Isomerase

3 of 48

1.72

1.29

0.0020

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00121

Triosephosphate isomerase

2 of 2

2.93

1.18

0.0074

PF01116

Fructose-bisphosphate aldolase class-II

2 of 3

2.75

1.17

0.0074

PF14833

NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase

2 of 6

2.45

1.06

0.0114

PF03446

NAD binding domain of 6-phosphogluconate dehydrogenase

2 of 9

2.27

0.96

0.0168

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013785

Aldolase-type TIM barrel

4 of 73

1.67

1.15

0.0038

IPR035990

Triosephosphate isomerase superfamily

2 of 2

2.93

1.1

0.0105

IPR000652

Triosephosphate isomerase

2 of 2

2.93

1.1

0.0105

IPR000771

Fructose-bisphosphate aldolase, class-II

2 of 3

2.75

1.09

0.0105

IPR029154

3-hydroxyisobutyrate dehydrogenase-like, NAD-binding domain

2 of 6

2.45

0.94

0.0195

(more ...)

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