nphp3 protein (Betta splendens) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

nphp3

Nephrocystin 3. (1313 aa)

Predicted Functional Partners:

leo1

0.970

LOC114862841

0.873

tep1

0.814

LOC114858522

0.806

KIF5C

0.806

LOC114844512

0.806

LOC114847415

0.806

kif5a

0.806

KIF5B

0.806

LOC114866637

0.765

Your Current Organism:

Betta splendens

NCBI taxonomy Id: 158456
Other names: B. splendens, Siamese fighting fish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KIF5B	KIF5C	ENSBSLP00000055037	ENSBSLP00000009181	Kinesin-1 heavy chain-like.	Kinesin heavy chain-like.	0.668
KIF5B	LOC114844512	ENSBSLP00000055037	ENSBSLP00000046131	Kinesin-1 heavy chain-like.	Kinesin-1 heavy chain.	0.819
KIF5B	LOC114847415	ENSBSLP00000055037	ENSBSLP00000053072	Kinesin-1 heavy chain-like.	Kinesin heavy chain-like.	0.667
KIF5B	LOC114858522	ENSBSLP00000055037	ENSBSLP00000006589	Kinesin-1 heavy chain-like.	Kinesin heavy chain-like.	0.667
KIF5B	LOC114862841	ENSBSLP00000055037	ENSBSLP00000051149	Kinesin-1 heavy chain-like.	Kinesin-like protein KIN-14E.	0.904
KIF5B	kif5a	ENSBSLP00000055037	ENSBSLP00000053940	Kinesin-1 heavy chain-like.	Kinesin family member 5A.	0.667
KIF5B	nphp3	ENSBSLP00000055037	ENSBSLP00000024205	Kinesin-1 heavy chain-like.	Nephrocystin 3.	0.806
KIF5C	KIF5B	ENSBSLP00000009181	ENSBSLP00000055037	Kinesin heavy chain-like.	Kinesin-1 heavy chain-like.	0.668
KIF5C	LOC114844512	ENSBSLP00000009181	ENSBSLP00000046131	Kinesin heavy chain-like.	Kinesin-1 heavy chain.	0.809
KIF5C	LOC114858522	ENSBSLP00000009181	ENSBSLP00000006589	Kinesin heavy chain-like.	Kinesin heavy chain-like.	0.516
KIF5C	LOC114862841	ENSBSLP00000009181	ENSBSLP00000051149	Kinesin heavy chain-like.	Kinesin-like protein KIN-14E.	0.904
KIF5C	kif5a	ENSBSLP00000009181	ENSBSLP00000053940	Kinesin heavy chain-like.	Kinesin family member 5A.	0.516
KIF5C	nphp3	ENSBSLP00000009181	ENSBSLP00000024205	Kinesin heavy chain-like.	Nephrocystin 3.	0.806
LOC114844512	KIF5B	ENSBSLP00000046131	ENSBSLP00000055037	Kinesin-1 heavy chain.	Kinesin-1 heavy chain-like.	0.819
LOC114844512	KIF5C	ENSBSLP00000046131	ENSBSLP00000009181	Kinesin-1 heavy chain.	Kinesin heavy chain-like.	0.809
LOC114844512	LOC114847415	ENSBSLP00000046131	ENSBSLP00000053072	Kinesin-1 heavy chain.	Kinesin heavy chain-like.	0.809
LOC114844512	LOC114858522	ENSBSLP00000046131	ENSBSLP00000006589	Kinesin-1 heavy chain.	Kinesin heavy chain-like.	0.510
LOC114844512	LOC114862841	ENSBSLP00000046131	ENSBSLP00000051149	Kinesin-1 heavy chain.	Kinesin-like protein KIN-14E.	0.904
LOC114844512	kif5a	ENSBSLP00000046131	ENSBSLP00000053940	Kinesin-1 heavy chain.	Kinesin family member 5A.	0.510
LOC114844512	nphp3	ENSBSLP00000046131	ENSBSLP00000024205	Kinesin-1 heavy chain.	Nephrocystin 3.	0.806

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

43

average node degree:

7.82

avg. local clustering coefficient:

0.927

expected number of edges:

11

PPI enrichment p-value:

1.65e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006032

Chitin catabolic process

3 of 46

2.17

1.91

0.0013

GO:0005975

Carbohydrate metabolic process

5 of 391

1.47

1.67

0.00017

GO:0000272

Polysaccharide catabolic process

3 of 132

1.72

1.37

0.0051

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004553

Hydrolase activity, hydrolyzing O-glycosyl compounds

5 of 189

1.78

2.82

2.09e-06

GO:0004568

Chitinase activity

3 of 38

2.26

2.41

0.00022

GO:0008061

Chitin binding

3 of 49

2.15

2.24

0.00034

GO:0102148

N-acetyl-beta-D-galactosaminidase activity

2 of 8

2.76

1.89

0.0022

GO:0004563

beta-N-acetylhexosaminidase activity

2 of 8

2.76

1.89

0.0022

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005576

Extracellular region

5 of 432

1.42

1.7

6.50e-05

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:21184821

(2011) Inhibition of 2,4-dinitrofluorobenzene-induced atopic dermatitis by topical application of the butanol extract of Cordyceps bassiana in NCNga mice.

2 of 7

2.82

2.05

0.0013

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:16527

Glycosyl hydrolases family 18, and beta-Lactam resistance

5 of 15

2.88

7.31

1.73e-11

CL:16544

Glycosyl hydrolases family 18

3 of 6

3.06

4.43

5.55e-07

CL:16530

beta-Lactam resistance, and Beta-acetyl hexosaminidase like

2 of 5

2.96

2.36

0.00049

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00520

Amino sugar and nucleotide sugar metabolism

5 of 177

1.81

3.25

1.49e-07

map00604

Glycosphingolipid biosynthesis - ganglio series

2 of 13

2.55

2.04

0.0012

map00603

Glycosphingolipid biosynthesis - globo and isoglobo series

2 of 19

2.38

1.92

0.0016

map00511

Other glycan degradation

2 of 22

2.32

1.9

0.0016

map00531

Glycosaminoglycan degradation

2 of 29

2.2

1.78

0.0022

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2160916

Hyaluronan uptake and degradation

2 of 9

2.71

1.56

0.0065

MAP-2024101

CS/DS degradation

2 of 8

2.76

1.56

0.0065

MAP-1793185

Chondroitin sulfate/dermatan sulfate metabolism

2 of 8

2.76

1.56

0.0065

MAP-2022857

Keratan sulfate degradation

2 of 13

2.55

1.54

0.0065

MAP-1638074

Keratan sulfate/keratin metabolism

2 of 13

2.55

1.54

0.0065

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009277

Fungal-type cell wall

3 of 48

2.16

2.03

0.00081

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0326

Glycosidase

4 of 72

2.1

3.37

2.15e-06

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00704

Glycosyl hydrolases family 18

3 of 13

2.72

3.23

2.32e-05

PF14845

Beta-acetyl hexosaminidase like

2 of 3

3.18

2.23

0.00079

PF00728

Glycosyl hydrolase family 20, catalytic domain

2 of 9

2.71

1.8

0.0029

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017853

Glycoside hydrolase superfamily

5 of 117

1.99

3.53

3.60e-07

IPR001223

Glycoside hydrolase family 18, catalytic domain

3 of 29

2.37

2.4

0.00028

IPR029019

Beta-hexosaminidase, eukaryotic type, N-terminal

2 of 3

3.18

2.05

0.0014

IPR025705

Beta-hexosaminidase

2 of 9

2.71

1.58

0.0060

IPR015883

Glycoside hydrolase family 20, catalytic domain

2 of 9

2.71

1.58

0.0060

(more ...)

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