sqor protein (Betta splendens) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

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[Homology]

Score

sqor

Sulfide quinone oxidoreductase. (451 aa)

Predicted Functional Partners:

LOC114843311

0.930

cth

0.916

fdx1

0.901

fdx2

0.901

suox

0.885

LOC114862208

0.880

pipox

0.880

LOC114865084

0.880

acod1

0.880

ddo

0.880

Your Current Organism:

Betta splendens

NCBI taxonomy Id: 158456
Other names: B. splendens, Siamese fighting fish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC114843311	cth	ENSBSLP00000044888	ENSBSLP00000003620	Persulfide dioxygenase ETHE1, mitochondrial-like.	Cystathionine gamma-lyase.	0.453
LOC114843311	fdx1	ENSBSLP00000044888	ENSBSLP00000007261	Persulfide dioxygenase ETHE1, mitochondrial-like.	Ferredoxin 1.	0.595
LOC114843311	fdx2	ENSBSLP00000044888	ENSBSLP00000010143	Persulfide dioxygenase ETHE1, mitochondrial-like.	Ferredoxin 2.	0.595
LOC114843311	sqor	ENSBSLP00000044888	ENSBSLP00000031632	Persulfide dioxygenase ETHE1, mitochondrial-like.	Sulfide quinone oxidoreductase.	0.930
LOC114843311	suox	ENSBSLP00000044888	ENSBSLP00000004215	Persulfide dioxygenase ETHE1, mitochondrial-like.	Sulfite oxidase.	0.931
LOC114862208	LOC114865084	ENSBSLP00000003669	ENSBSLP00000035546	D-amino-acid oxidase-like.	Cis-aconitate decarboxylase-like.	0.653
LOC114862208	acod1	ENSBSLP00000003669	ENSBSLP00000038156	D-amino-acid oxidase-like.	Aconitate decarboxylase 1.	0.653
LOC114862208	cth	ENSBSLP00000003669	ENSBSLP00000003620	D-amino-acid oxidase-like.	Cystathionine gamma-lyase.	0.655
LOC114862208	pipox	ENSBSLP00000003669	ENSBSLP00000007518	D-amino-acid oxidase-like.	Pipecolic acid and sarcosine oxidase.	0.873
LOC114862208	sqor	ENSBSLP00000003669	ENSBSLP00000031632	D-amino-acid oxidase-like.	Sulfide quinone oxidoreductase.	0.880
LOC114862208	suox	ENSBSLP00000003669	ENSBSLP00000004215	D-amino-acid oxidase-like.	Sulfite oxidase.	0.549
LOC114865084	LOC114862208	ENSBSLP00000035546	ENSBSLP00000003669	Cis-aconitate decarboxylase-like.	D-amino-acid oxidase-like.	0.653
LOC114865084	acod1	ENSBSLP00000035546	ENSBSLP00000038156	Cis-aconitate decarboxylase-like.	Aconitate decarboxylase 1.	0.842
LOC114865084	cth	ENSBSLP00000035546	ENSBSLP00000003620	Cis-aconitate decarboxylase-like.	Cystathionine gamma-lyase.	0.638
LOC114865084	ddo	ENSBSLP00000035546	ENSBSLP00000057119	Cis-aconitate decarboxylase-like.	D-aspartate oxidase.	0.653
LOC114865084	sqor	ENSBSLP00000035546	ENSBSLP00000031632	Cis-aconitate decarboxylase-like.	Sulfide quinone oxidoreductase.	0.880
acod1	LOC114862208	ENSBSLP00000038156	ENSBSLP00000003669	Aconitate decarboxylase 1.	D-amino-acid oxidase-like.	0.653
acod1	LOC114865084	ENSBSLP00000038156	ENSBSLP00000035546	Aconitate decarboxylase 1.	Cis-aconitate decarboxylase-like.	0.842
acod1	cth	ENSBSLP00000038156	ENSBSLP00000003620	Aconitate decarboxylase 1.	Cystathionine gamma-lyase.	0.638
acod1	ddo	ENSBSLP00000038156	ENSBSLP00000057119	Aconitate decarboxylase 1.	D-aspartate oxidase.	0.653

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.915

expected number of edges:

10

PPI enrichment p-value:

2.83e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051382

Kinetochore assembly

3 of 12

2.72

1.93

0.00029

GO:0007059

Chromosome segregation

5 of 220

1.68

1.59

0.00029

GO:0000712

Resolution of meiotic recombination intermediates

2 of 17

2.4

0.87

0.0257

GO:0036297

Interstrand cross-link repair

2 of 25

2.23

0.81

0.0327

GO:0031297

Replication fork processing

2 of 29

2.16

0.78

0.0359

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0080122

AMP transmembrane transporter activity

2 of 4

3.02

1.16

0.0082

GO:0015228

Coenzyme A transmembrane transporter activity

2 of 4

3.02

1.16

0.0082

GO:0043262

Adenosine-diphosphatase activity

2 of 7

2.78

1.15

0.0082

GO:0015217

ADP transmembrane transporter activity

2 of 9

2.67

1.15

0.0082

GO:0005347

ATP transmembrane transporter activity

2 of 16

2.42

1.01

0.0140

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000775

Chromosome, centromeric region

5 of 150

1.85

2.32

7.01e-06

GO:0071821

FANCM-MHF complex

2 of 5

2.93

1.58

0.0014

GO:0043240

Fanconi anaemia nuclear complex

2 of 9

2.67

1.4

0.0028

GO:0000776

Kinetochore

3 of 101

1.8

1.24

0.0030

GO:0005694

Chromosome

6 of 900

1.15

1.03

0.00057

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4083

Centromere complex assembly, and AMP transport

7 of 16

2.97

8.07

5.63e-16

CL:4087

Centromere complex assembly, and Inner kinetochore

6 of 11

3.06

7.34

2.20e-14

CL:4090

Centromere complex assembly, and Inner kinetochore

3 of 6

3.02

3.0

3.36e-06

CL:2471

Fanconi anaemia nuclear complex, and CENP-S protein

2 of 12

2.55

1.13

0.0085

CL:2198

DNA replication, and Fanconi anemia pathway

3 of 165

1.58

0.8

0.0229

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

sdu03460

Fanconi anemia pathway

2 of 46

1.96

0.76

0.0376

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-774815

Nucleosome assembly

5 of 62

2.23

3.39

1.30e-07

MAP-606279

Deposition of new CENPA-containing nucleosomes at the centromere

5 of 62

2.23

3.39

1.30e-07

MAP-73886

Chromosome Maintenance

5 of 129

1.91

2.64

1.47e-06

MAP-499943

Interconversion of nucleotide di- and triphosphates

3 of 43

2.17

1.72

0.00049

MAP-141444

Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal

3 of 108

1.77

1.11

0.0057

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0071821

FANCM-MHF complex

2 of 5

2.93

1.44

0.0025

GOCC:0000779

Condensed chromosome, centromeric region

3 of 48

2.12

1.36

0.0025

GOCC:0000776

Kinetochore

3 of 54

2.07

1.35

0.0025

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