LOC114855547 protein (Betta splendens) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

LOC114855547

Diphosphoinositol polyphosphate phosphohydrolase 1. (189 aa)

Predicted Functional Partners:

LOC114847215

0.879

nudt12

0.872

ENSBSLP00000048337

0.865

trpm2

0.848

edc4

0.838

dcp1a

0.826

dcp1b

0.826

itpa

0.813

xrn1

0.813

patl1

0.806

Your Current Organism:

Betta splendens

NCBI taxonomy Id: 158456
Other names: B. splendens, Siamese fighting fish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSBSLP00000048337	LOC114847215	ENSBSLP00000048337	ENSBSLP00000012565	annotation not available	Thioredoxin domain-containing protein 3 homolog.	0.941
ENSBSLP00000048337	LOC114855547	ENSBSLP00000048337	ENSBSLP00000031817	annotation not available	Diphosphoinositol polyphosphate phosphohydrolase 1.	0.865
ENSBSLP00000048337	itpa	ENSBSLP00000048337	ENSBSLP00000032015	annotation not available	Inosine triphosphatase.	0.919
LOC114847215	ENSBSLP00000048337	ENSBSLP00000012565	ENSBSLP00000048337	Thioredoxin domain-containing protein 3 homolog.	annotation not available	0.941
LOC114847215	LOC114855547	ENSBSLP00000012565	ENSBSLP00000031817	Thioredoxin domain-containing protein 3 homolog.	Diphosphoinositol polyphosphate phosphohydrolase 1.	0.879
LOC114847215	itpa	ENSBSLP00000012565	ENSBSLP00000032015	Thioredoxin domain-containing protein 3 homolog.	Inosine triphosphatase.	0.911
LOC114847215	nudt12	ENSBSLP00000012565	ENSBSLP00000029627	Thioredoxin domain-containing protein 3 homolog.	Nudix hydrolase 12.	0.502
LOC114855547	ENSBSLP00000048337	ENSBSLP00000031817	ENSBSLP00000048337	Diphosphoinositol polyphosphate phosphohydrolase 1.	annotation not available	0.865
LOC114855547	LOC114847215	ENSBSLP00000031817	ENSBSLP00000012565	Diphosphoinositol polyphosphate phosphohydrolase 1.	Thioredoxin domain-containing protein 3 homolog.	0.879
LOC114855547	dcp1a	ENSBSLP00000031817	ENSBSLP00000006881	Diphosphoinositol polyphosphate phosphohydrolase 1.	Decapping mRNA 1A.	0.826
LOC114855547	dcp1b	ENSBSLP00000031817	ENSBSLP00000050107	Diphosphoinositol polyphosphate phosphohydrolase 1.	Decapping mRNA 1B.	0.826
LOC114855547	edc4	ENSBSLP00000031817	ENSBSLP00000026224	Diphosphoinositol polyphosphate phosphohydrolase 1.	Enhancer of mRNA decapping 4.	0.838
LOC114855547	itpa	ENSBSLP00000031817	ENSBSLP00000032015	Diphosphoinositol polyphosphate phosphohydrolase 1.	Inosine triphosphatase.	0.813
LOC114855547	nudt12	ENSBSLP00000031817	ENSBSLP00000029627	Diphosphoinositol polyphosphate phosphohydrolase 1.	Nudix hydrolase 12.	0.872
LOC114855547	patl1	ENSBSLP00000031817	ENSBSLP00000034437	Diphosphoinositol polyphosphate phosphohydrolase 1.	PAT1 homolog 1, processing body mRNA decay factor.	0.806
LOC114855547	trpm2	ENSBSLP00000031817	ENSBSLP00000023700	Diphosphoinositol polyphosphate phosphohydrolase 1.	Transient receptor potential cation channel subfamily M member 2.	0.848
LOC114855547	xrn1	ENSBSLP00000031817	ENSBSLP00000033063	Diphosphoinositol polyphosphate phosphohydrolase 1.	5'-3' exoribonuclease 1.	0.813
dcp1a	LOC114855547	ENSBSLP00000006881	ENSBSLP00000031817	Decapping mRNA 1A.	Diphosphoinositol polyphosphate phosphohydrolase 1.	0.826
dcp1a	dcp1b	ENSBSLP00000006881	ENSBSLP00000050107	Decapping mRNA 1A.	Decapping mRNA 1B.	0.978
dcp1a	edc4	ENSBSLP00000006881	ENSBSLP00000026224	Decapping mRNA 1A.	Enhancer of mRNA decapping 4.	0.983

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

43

average node degree:

7.82

avg. local clustering coefficient:

0.927

expected number of edges:

11

PPI enrichment p-value:

1.65e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006032

Chitin catabolic process

3 of 46

2.17

1.91

0.0013

GO:0005975

Carbohydrate metabolic process

5 of 391

1.47

1.67

0.00017

GO:0000272

Polysaccharide catabolic process

3 of 132

1.72

1.37

0.0051

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004553

Hydrolase activity, hydrolyzing O-glycosyl compounds

5 of 189

1.78

2.82

2.09e-06

GO:0004568

Chitinase activity

3 of 38

2.26

2.41

0.00022

GO:0008061

Chitin binding

3 of 49

2.15

2.24

0.00034

GO:0102148

N-acetyl-beta-D-galactosaminidase activity

2 of 8

2.76

1.89

0.0022

GO:0004563

beta-N-acetylhexosaminidase activity

2 of 8

2.76

1.89

0.0022

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005576

Extracellular region

5 of 432

1.42

1.7

6.50e-05

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:21184821

(2011) Inhibition of 2,4-dinitrofluorobenzene-induced atopic dermatitis by topical application of the butanol extract of Cordyceps bassiana in NCNga mice.

2 of 7

2.82

2.05

0.0013

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:16527

Glycosyl hydrolases family 18, and beta-Lactam resistance

5 of 15

2.88

7.31

1.73e-11

CL:16544

Glycosyl hydrolases family 18

3 of 6

3.06

4.43

5.55e-07

CL:16530

beta-Lactam resistance, and Beta-acetyl hexosaminidase like

2 of 5

2.96

2.36

0.00049

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00520

Amino sugar and nucleotide sugar metabolism

5 of 177

1.81

3.25

1.49e-07

map00604

Glycosphingolipid biosynthesis - ganglio series

2 of 13

2.55

2.04

0.0012

map00603

Glycosphingolipid biosynthesis - globo and isoglobo series

2 of 19

2.38

1.92

0.0016

map00511

Other glycan degradation

2 of 22

2.32

1.9

0.0016

map00531

Glycosaminoglycan degradation

2 of 29

2.2

1.78

0.0022

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2160916

Hyaluronan uptake and degradation

2 of 9

2.71

1.56

0.0065

MAP-2024101

CS/DS degradation

2 of 8

2.76

1.56

0.0065

MAP-1793185

Chondroitin sulfate/dermatan sulfate metabolism

2 of 8

2.76

1.56

0.0065

MAP-2022857

Keratan sulfate degradation

2 of 13

2.55

1.54

0.0065

MAP-1638074

Keratan sulfate/keratin metabolism

2 of 13

2.55

1.54

0.0065

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009277

Fungal-type cell wall

3 of 48

2.16

2.03

0.00081

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0326

Glycosidase

4 of 72

2.1

3.37

2.15e-06

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00704

Glycosyl hydrolases family 18

3 of 13

2.72

3.23

2.32e-05

PF14845

Beta-acetyl hexosaminidase like

2 of 3

3.18

2.23

0.00079

PF00728

Glycosyl hydrolase family 20, catalytic domain

2 of 9

2.71

1.8

0.0029

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017853

Glycoside hydrolase superfamily

5 of 117

1.99

3.53

3.60e-07

IPR001223

Glycoside hydrolase family 18, catalytic domain

3 of 29

2.37

2.4

0.00028

IPR029019

Beta-hexosaminidase, eukaryotic type, N-terminal

2 of 3

3.18

2.05

0.0014

IPR025705

Beta-hexosaminidase

2 of 9

2.71

1.58

0.0060

IPR015883

Glycoside hydrolase family 20, catalytic domain

2 of 9

2.71

1.58

0.0060

(more ...)

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