GNAZ protein (Betta splendens) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

GNAZ

G protein subunit alpha z. (355 aa)

Predicted Functional Partners:

LOC114865855

0.963

gng3

0.955

LOC114859789

0.952

LOC114845994

0.952

gng10

0.941

gng8

0.941

GNG4

0.923

gng2

0.923

LOC114854338

0.922

ENSBSLP00000013075

0.922

Your Current Organism:

Betta splendens

NCBI taxonomy Id: 158456
Other names: B. splendens, Siamese fighting fish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSBSLP00000013075	GNAZ	ENSBSLP00000013075	ENSBSLP00000035057	Si:dkey-117i10.1.	G protein subunit alpha z.	0.922
ENSBSLP00000013075	GNG4	ENSBSLP00000013075	ENSBSLP00000013924	Si:dkey-117i10.1.	G protein subunit gamma 4.	0.811
ENSBSLP00000013075	LOC114854338	ENSBSLP00000013075	ENSBSLP00000008871	Si:dkey-117i10.1.	Guanine nucleotide-binding protein subunit alpha-11-like.	0.930
ENSBSLP00000013075	LOC114865855	ENSBSLP00000013075	ENSBSLP00000015102	Si:dkey-117i10.1.	Guanine nucleotide-binding protein G(T) subunit gamma-T1-like.	0.933
ENSBSLP00000013075	gng2	ENSBSLP00000013075	ENSBSLP00000035475	Si:dkey-117i10.1.	G protein subunit gamma 2.	0.809
ENSBSLP00000013075	gng3	ENSBSLP00000013075	ENSBSLP00000023327	Si:dkey-117i10.1.	G protein subunit gamma 3.	0.932
GNAZ	ENSBSLP00000013075	ENSBSLP00000035057	ENSBSLP00000013075	G protein subunit alpha z.	Si:dkey-117i10.1.	0.922
GNAZ	GNG4	ENSBSLP00000035057	ENSBSLP00000013924	G protein subunit alpha z.	G protein subunit gamma 4.	0.923
GNAZ	LOC114845994	ENSBSLP00000035057	ENSBSLP00000009974	G protein subunit alpha z.	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2-like.	0.952
GNAZ	LOC114854338	ENSBSLP00000035057	ENSBSLP00000008871	G protein subunit alpha z.	Guanine nucleotide-binding protein subunit alpha-11-like.	0.922
GNAZ	LOC114859789	ENSBSLP00000035057	ENSBSLP00000008956	G protein subunit alpha z.	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13-like.	0.952
GNAZ	LOC114865855	ENSBSLP00000035057	ENSBSLP00000015102	G protein subunit alpha z.	Guanine nucleotide-binding protein G(T) subunit gamma-T1-like.	0.963
GNAZ	gng10	ENSBSLP00000035057	ENSBSLP00000021887	G protein subunit alpha z.	G protein subunit gamma 10.	0.941
GNAZ	gng2	ENSBSLP00000035057	ENSBSLP00000035475	G protein subunit alpha z.	G protein subunit gamma 2.	0.923
GNAZ	gng3	ENSBSLP00000035057	ENSBSLP00000023327	G protein subunit alpha z.	G protein subunit gamma 3.	0.955
GNAZ	gng8	ENSBSLP00000035057	ENSBSLP00000057266	G protein subunit alpha z.	G protein subunit gamma 8.	0.941
GNG4	ENSBSLP00000013075	ENSBSLP00000013924	ENSBSLP00000013075	G protein subunit gamma 4.	Si:dkey-117i10.1.	0.811
GNG4	GNAZ	ENSBSLP00000013924	ENSBSLP00000035057	G protein subunit gamma 4.	G protein subunit alpha z.	0.923
GNG4	LOC114845994	ENSBSLP00000013924	ENSBSLP00000009974	G protein subunit gamma 4.	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2-like.	0.858
GNG4	LOC114854338	ENSBSLP00000013924	ENSBSLP00000008871	G protein subunit gamma 4.	Guanine nucleotide-binding protein subunit alpha-11-like.	0.894

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

28

PPI enrichment p-value:

1.32e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006351

Transcription, DNA-templated

7 of 25

2.0

3.95

5.53e-10

GO:0006352

DNA-templated transcription, initiation

3 of 15

1.85

1.41

0.0014

GO:0019438

Aromatic compound biosynthetic process

8 of 270

1.02

1.06

1.90e-05

GO:0018130

Heterocycle biosynthetic process

8 of 294

0.98

0.99

3.13e-05

GO:1901362

Organic cyclic compound biosynthetic process

8 of 305

0.97

0.96

3.63e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003899

DNA-directed 5-3 RNA polymerase activity

4 of 6

2.37

2.73

5.59e-06

GO:0016987

Sigma factor activity

3 of 15

1.85

1.33

0.0021

GO:0003677

DNA binding

7 of 307

0.91

0.75

0.0010

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000428

DNA-directed RNA polymerase complex

4 of 9

2.2

2.71

3.94e-06

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37075846

(2023) Transcription regulation by CarD in mycobacteria is guided by basal promoter kinetics.

4 of 6

2.37

2.55

1.31e-05

PMID:38741736

(2024) Function of the RNA-targeting class 2 type VI CRISPR Cas system of Rhodobacter capsulatus.

3 of 3

2.55

2.0

0.00020

PMID:30200857

(2018) Transcriptional Responses to ppGpp and DksA.

4 of 14

2.0

1.99

9.46e-05

PMID:34254822

(2021) Promoter Architecture Differences among Alphaproteobacteria and Other Bacterial Taxa.

3 of 5

2.33

1.84

0.00034

PMID:24516534

(2014) Transcriptional profiling of nitrogen fixation and the role of NifA in the diazotrophic endophyte Azoarcus sp. strain BH72.

4 of 23

1.79

1.67

0.00027

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:215

RNA polymerase, and Transcription termination

3 of 5

2.33

1.63

0.00087

CL:92

Ribosome, and RNA polymerase

4 of 67

1.32

0.8

0.0141

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

rsp03020

RNA polymerase

4 of 4

2.55

3.46

2.66e-07

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000428

DNA-directed RNA polymerase complex

7 of 66

1.57

2.47

6.05e-08

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0240

DNA-directed RNA polymerase

4 of 9

2.2

2.63

5.88e-06

KW-0731

Sigma factor

3 of 15

1.85

1.51

0.00081

KW-0804

Transcription

7 of 150

1.22

1.43

5.88e-06

KW-0548

Nucleotidyltransferase

4 of 45

1.5

1.36

0.00055

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04545

Sigma-70, region 4

3 of 7

2.18

1.52

0.0013

PF04542

Sigma-70 region 2

3 of 11

1.98

1.39

0.0019

PF00140

Sigma-70 factor, region 1.2

2 of 2

2.55

1.12

0.0091

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000943

RNA polymerase sigma-70

3 of 4

2.42

1.62

0.00096

IPR007630

RNA polymerase sigma-70 region 4

3 of 7

2.18

1.47

0.0016

IPR014284

RNA polymerase sigma-70 like domain

3 of 11

1.98

1.28

0.0033

IPR013325

RNA polymerase sigma factor, region 2

3 of 11

1.98

1.28

0.0033

IPR007627

RNA polymerase sigma-70 region 2

3 of 11

1.98

1.28

0.0033

(more ...)

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