ENSBSLP00000041259 protein (Betta splendens)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

ENSBSLP00000041259

annotation not available (204 aa)

Predicted Functional Partners:

LOC114865816

0.619

LOC114859959

0.619

grn

0.619

ctso

0.602

cd74

0.589

rps14

0.589

LOC114864300

0.577

apaf1

0.551

LOC114853458

0.528

LOC114853459

0.528

Your Current Organism:

Betta splendens

NCBI taxonomy Id: 158456
Other names: B. splendens, Siamese fighting fish

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSBSLP00000041259	LOC114853458	ENSBSLP00000041259	ENSBSLP00000002843	annotation not available	cystatin-A-like.	0.528
ENSBSLP00000041259	LOC114853459	ENSBSLP00000041259	ENSBSLP00000002884	annotation not available	cystatin-A5-like.	0.528
ENSBSLP00000041259	LOC114859959	ENSBSLP00000041259	ENSBSLP00000026035	annotation not available	Uncharacterized LOC114859959.	0.619
ENSBSLP00000041259	LOC114864300	ENSBSLP00000041259	ENSBSLP00000028681	annotation not available	Cathepsin F-like.	0.577
ENSBSLP00000041259	LOC114865816	ENSBSLP00000041259	ENSBSLP00000019888	annotation not available	Progranulin-like.	0.619
ENSBSLP00000041259	apaf1	ENSBSLP00000041259	ENSBSLP00000021893	annotation not available	Apoptotic peptidase activating factor 1.	0.551
ENSBSLP00000041259	cd74	ENSBSLP00000041259	ENSBSLP00000036694	annotation not available	CD74 molecule.	0.589
ENSBSLP00000041259	ctso	ENSBSLP00000041259	ENSBSLP00000039871	annotation not available	Cathepsin O.	0.602
ENSBSLP00000041259	grn	ENSBSLP00000041259	ENSBSLP00000044155	annotation not available	Granulin precursor.	0.619
ENSBSLP00000041259	rps14	ENSBSLP00000041259	ENSBSLP00000042337	annotation not available	Ribosomal protein S14.	0.589
LOC114853458	ENSBSLP00000041259	ENSBSLP00000002843	ENSBSLP00000041259	cystatin-A-like.	annotation not available	0.528
LOC114853458	LOC114864300	ENSBSLP00000002843	ENSBSLP00000028681	cystatin-A-like.	Cathepsin F-like.	0.509
LOC114853458	apaf1	ENSBSLP00000002843	ENSBSLP00000021893	cystatin-A-like.	Apoptotic peptidase activating factor 1.	0.543
LOC114853458	ctso	ENSBSLP00000002843	ENSBSLP00000039871	cystatin-A-like.	Cathepsin O.	0.509
LOC114853459	ENSBSLP00000041259	ENSBSLP00000002884	ENSBSLP00000041259	cystatin-A5-like.	annotation not available	0.528
LOC114853459	LOC114864300	ENSBSLP00000002884	ENSBSLP00000028681	cystatin-A5-like.	Cathepsin F-like.	0.509
LOC114853459	apaf1	ENSBSLP00000002884	ENSBSLP00000021893	cystatin-A5-like.	Apoptotic peptidase activating factor 1.	0.543
LOC114853459	ctso	ENSBSLP00000002884	ENSBSLP00000039871	cystatin-A5-like.	Cathepsin O.	0.509
LOC114859959	ENSBSLP00000041259	ENSBSLP00000026035	ENSBSLP00000041259	Uncharacterized LOC114859959.	annotation not available	0.619
LOC114859959	LOC114864300	ENSBSLP00000026035	ENSBSLP00000028681	Uncharacterized LOC114859959.	Cathepsin F-like.	0.651

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.948

expected number of edges:

47

PPI enrichment p-value:

0.53

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000398

mRNA splicing, via spliceosome

7 of 229

1.81

3.04

2.77e-08

GO:0010467

Gene expression

9 of 1738

1.04

1.14

4.44e-06

GO:0022618

Ribonucleoprotein complex assembly

3 of 155

1.61

0.8

0.0239

GO:0000387

Spliceosomal snRNP assembly

2 of 30

2.15

0.75

0.0415

GO:0034641

Cellular nitrogen compound metabolic process

9 of 3050

0.79

0.67

0.00044

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1990935

Splicing factor binding

2 of 4

3.02

1.34

0.0038

GO:0003723

RNA binding

8 of 1208

1.14

1.24

2.24e-05

GO:0003676

Nucleic acid binding

9 of 3699

0.71

0.53

0.0038

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005686

U2 snRNP

5 of 20

2.72

5.12

1.89e-10

GO:0071011

Precatalytic spliceosome

6 of 53

2.38

4.86

1.24e-10

GO:0005684

U2-type spliceosomal complex

6 of 92

2.14

4.22

5.76e-10

GO:0071005

U2-type precatalytic spliceosome

5 of 48

2.34

4.12

5.07e-09

GO:0005681

Spliceosomal complex

7 of 176

1.92

3.93

1.89e-10

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:18986

U2 snRNP, and Nuclear cap binding complex

6 of 23

2.74

5.91

5.02e-12

CL:18988

U2 snRNP

4 of 12

2.84

4.05

3.05e-08

CL:19002

Splicing factor binding, and PSP, proline-rich

3 of 5

3.1

3.14

1.97e-06

CL:19016

U4 snRNP

2 of 5

2.92

1.53

0.0017

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03040

Spliceosome

7 of 266

1.74

3.21

1.84e-09

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72165

mRNA Splicing - Minor Pathway

6 of 59

2.33

4.64

2.98e-10

MAP-72172

mRNA Splicing

7 of 296

1.7

2.88

1.45e-08

MAP-72203

Processing of Capped Intron-Containing Pre-mRNA

7 of 391

1.57

2.48

5.54e-08

MAP-8953854

Metabolism of RNA

9 of 946

1.3

1.91

1.45e-08

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990904

Ribonucleoprotein complex

9 of 447

1.63

3.22

3.44e-11

GOCC:0097525

Spliceosomal snRNP complex

4 of 40

2.32

2.85

2.87e-06

GOCC:0005681

Spliceosomal complex

4 of 107

1.89

2.04

4.99e-05

GOCC:0005687

U4 snRNP

2 of 6

2.84

1.63

0.0011

GOCC:0005689

U12-type spliceosomal complex

2 of 8

2.72

1.53

0.0016

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0687

Ribonucleoprotein

4 of 93

1.96

2.16

3.14e-05

KW-0694

RNA-binding

4 of 347

1.38

1.06

0.0027

KW-0689

Ribosomal protein

2 of 63

1.82

0.7

0.0469

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