LOC114849858 protein (Betta splendens) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

LOC114849858

Alpha-1-antitrypsin homolog. (417 aa)

Predicted Functional Partners:

f2

0.928

LOC114844190

0.845

LOC114867652

0.794

LOC114869372

0.776

serpine1

0.754

plat

0.732

LOC114841773

0.732

serpinc1

0.717

lrp6

0.682

lrp5

0.682

Your Current Organism:

Betta splendens

NCBI taxonomy Id: 158456
Other names: B. splendens, Siamese fighting fish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC114841773	LOC114849858	ENSBSLP00000053501	ENSBSLP00000045872	Urokinase-type plasminogen activator-like.	Alpha-1-antitrypsin homolog.	0.732
LOC114841773	LOC114867652	ENSBSLP00000053501	ENSBSLP00000018857	Urokinase-type plasminogen activator-like.	Vitronectin-like.	0.889
LOC114841773	LOC114869372	ENSBSLP00000053501	ENSBSLP00000019647	Urokinase-type plasminogen activator-like.	Vitronectin-like.	0.889
LOC114841773	f2	ENSBSLP00000053501	ENSBSLP00000003347	Urokinase-type plasminogen activator-like.	Coagulation factor II, thrombin.	0.521
LOC114841773	lrp5	ENSBSLP00000053501	ENSBSLP00000030681	Urokinase-type plasminogen activator-like.	LDL receptor related protein 5.	0.590
LOC114841773	lrp6	ENSBSLP00000053501	ENSBSLP00000004777	Urokinase-type plasminogen activator-like.	LDL receptor related protein 6.	0.590
LOC114841773	serpinc1	ENSBSLP00000053501	ENSBSLP00000025037	Urokinase-type plasminogen activator-like.	Serpin family C member 1.	0.762
LOC114841773	serpine1	ENSBSLP00000053501	ENSBSLP00000001580	Urokinase-type plasminogen activator-like.	Serpin family E member 1.	0.983
LOC114844190	LOC114849858	ENSBSLP00000023755	ENSBSLP00000045872	Vitamin K-dependent protein C-like.	Alpha-1-antitrypsin homolog.	0.845
LOC114844190	LOC114867652	ENSBSLP00000023755	ENSBSLP00000018857	Vitamin K-dependent protein C-like.	Vitronectin-like.	0.420
LOC114844190	LOC114869372	ENSBSLP00000023755	ENSBSLP00000019647	Vitamin K-dependent protein C-like.	Vitronectin-like.	0.420
LOC114844190	f2	ENSBSLP00000023755	ENSBSLP00000003347	Vitamin K-dependent protein C-like.	Coagulation factor II, thrombin.	0.992
LOC114844190	serpinc1	ENSBSLP00000023755	ENSBSLP00000025037	Vitamin K-dependent protein C-like.	Serpin family C member 1.	0.932
LOC114844190	serpine1	ENSBSLP00000023755	ENSBSLP00000001580	Vitamin K-dependent protein C-like.	Serpin family E member 1.	0.908
LOC114849858	LOC114841773	ENSBSLP00000045872	ENSBSLP00000053501	Alpha-1-antitrypsin homolog.	Urokinase-type plasminogen activator-like.	0.732
LOC114849858	LOC114844190	ENSBSLP00000045872	ENSBSLP00000023755	Alpha-1-antitrypsin homolog.	Vitamin K-dependent protein C-like.	0.845
LOC114849858	LOC114867652	ENSBSLP00000045872	ENSBSLP00000018857	Alpha-1-antitrypsin homolog.	Vitronectin-like.	0.794
LOC114849858	LOC114869372	ENSBSLP00000045872	ENSBSLP00000019647	Alpha-1-antitrypsin homolog.	Vitronectin-like.	0.776
LOC114849858	f2	ENSBSLP00000045872	ENSBSLP00000003347	Alpha-1-antitrypsin homolog.	Coagulation factor II, thrombin.	0.928
LOC114849858	lrp5	ENSBSLP00000045872	ENSBSLP00000030681	Alpha-1-antitrypsin homolog.	LDL receptor related protein 5.	0.682

page 1 of 5

Network Stats

number of nodes:

6

number of edges:

5

average node degree:

1.67

avg. local clustering coefficient:

0.833

expected number of edges:

5

PPI enrichment p-value:

0.569

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006998

Nuclear envelope organization

7 of 28

2.73

7.04

2.20e-14

GO:0051664

Nuclear pore localization

4 of 5

3.23

4.5

6.47e-09

GO:0090435

Protein localization to nuclear envelope

4 of 10

2.93

4.01

4.11e-08

GO:0010256

Endomembrane system organization

8 of 387

1.65

2.94

2.43e-09

GO:0031507

Heterochromatin assembly

4 of 34

2.4

2.94

2.25e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005200

Structural constituent of cytoskeleton

4 of 74

2.06

2.02

9.44e-05

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005652

Nuclear lamina

4 of 8

3.03

4.25

1.57e-08

GO:0005882

Intermediate filament

4 of 57

2.18

2.68

4.39e-06

GO:0005635

Nuclear envelope

6 of 277

1.67

2.38

7.72e-07

GO:0031965

Nuclear membrane

5 of 174

1.79

2.33

4.39e-06

GO:0034451

Centriolar satellite

2 of 44

1.99

0.96

0.0149

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36295035

(2022) Single Cell in a Gravity Field.

4 of 42

2.31

2.4

2.39e-05

PMID:28666956

(2017) Coordination of cellular differentiation, polarity, mitosis and meiosis - New findings from early vertebrate oogenesis.

3 of 13

2.69

2.13

0.00012

PMID:37305677

(2023) Applications of advances in mRNA-based platforms as therapeutics and diagnostics in reproductive technologies.

3 of 15

2.63

2.12

0.00012

PMID:35230639

(2023) Cerium Oxide Nanoparticles Promote Osteoplastic Precursor Differentiation by Activating the Wnt Pathway.

3 of 15

2.63

2.12

0.00012

PMID:28256534

(2017) Cell Type-Specific Epigenomic Analysis Reveals a Uniquely Closed Chromatin Architecture in Mouse Rod Photoreceptors.

3 of 26

2.39

1.86

0.00032

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:20379

Mixed, incl. Breakdown of the nuclear lamina, and Mitotic nuclear membrane reassembly

9 of 14

3.14

11.89

3.62e-23

CL:20382

Barrier- to-autointegration factor, BAF, and Lamin Tail Domain

4 of 6

3.16

4.41

9.01e-09

CL:7330

Mixed, incl. Splicing factor, RBM39-like, and PWI domain superfamily

2 of 11

2.59

0.94

0.0194

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ola04210

Apoptosis

4 of 160

1.73

1.77

0.00012

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2995383

Initiation of Nuclear Envelope (NE) Reformation

7 of 20

2.88

7.97

5.98e-16

MAP-2995410

Nuclear Envelope (NE) Reassembly

7 of 73

2.31

5.61

1.06e-12

MAP-4419969

Depolymerisation of the Nuclear Lamina

5 of 17

2.8

5.35

8.24e-11

MAP-352238

Breakdown of the nuclear lamina

4 of 5

3.23

4.97

8.88e-10

MAP-2980766

Nuclear Envelope Breakdown

5 of 56

2.28

3.98

7.38e-09

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005652

Nuclear lamina

4 of 8

3.03

4.21

1.94e-08

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0403

Intermediate filament

4 of 51

2.23

2.79

2.88e-06

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00932

Lamin Tail Domain

4 of 4

3.33

4.62

4.09e-09

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036415

Lamin tail domain superfamily

4 of 4

3.33

4.35

1.28e-08

IPR001322

Lamin tail domain

4 of 5

3.23

4.34

1.28e-08

IPR039008

Intermediate filament, rod domain

4 of 52

2.22

2.38

2.21e-05

IPR018039

Intermediate filament protein, conserved site

3 of 29

2.35

1.7

0.00066

IPR029123

Splicing factor RBM39, linker

2 of 2

3.33

1.54

0.0017

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01391

Intermediate filament protein

4 of 52

2.22

2.6

7.22e-06

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