LOC114845438 protein (Betta splendens) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

LOC114845438

Pepsin A-like. (379 aa)

Predicted Functional Partners:

LOC114870387

0.811

LOC114864300

0.759

ctso

0.750

ctsc

0.739

ctsh

0.708

atp6ap2

0.692

LOC114852126

0.672

LOC114849798

0.672

ctsa

0.643

LOC114852309

0.643

Your Current Organism:

Betta splendens

NCBI taxonomy Id: 158456
Other names: B. splendens, Siamese fighting fish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC114845438	LOC114849798	ENSBSLP00000050384	ENSBSLP00000023947	Pepsin A-like.	Cathepsin B-like.	0.672
LOC114845438	LOC114852126	ENSBSLP00000050384	ENSBSLP00000020575	Pepsin A-like.	Cathepsin B-like.	0.672
LOC114845438	LOC114852309	ENSBSLP00000050384	ENSBSLP00000009486	Pepsin A-like.	Lysosomal protective protein-like.	0.643
LOC114845438	LOC114864300	ENSBSLP00000050384	ENSBSLP00000028681	Pepsin A-like.	Cathepsin F-like.	0.759
LOC114845438	LOC114870387	ENSBSLP00000050384	ENSBSLP00000054097	Pepsin A-like.	Alpha-1-antitrypsin-like protein GS55-MS.	0.811
LOC114845438	atp6ap2	ENSBSLP00000050384	ENSBSLP00000045221	Pepsin A-like.	ATPase H+ transporting accessory protein 2.	0.692
LOC114845438	ctsa	ENSBSLP00000050384	ENSBSLP00000008569	Pepsin A-like.	Cathepsin A.	0.643
LOC114845438	ctsc	ENSBSLP00000050384	ENSBSLP00000032438	Pepsin A-like.	Cathepsin C.	0.739
LOC114845438	ctsh	ENSBSLP00000050384	ENSBSLP00000048372	Pepsin A-like.	Cathepsin H.	0.708
LOC114845438	ctso	ENSBSLP00000050384	ENSBSLP00000039871	Pepsin A-like.	Cathepsin O.	0.750
LOC114849798	LOC114845438	ENSBSLP00000023947	ENSBSLP00000050384	Cathepsin B-like.	Pepsin A-like.	0.672
LOC114849798	LOC114852126	ENSBSLP00000023947	ENSBSLP00000020575	Cathepsin B-like.	Cathepsin B-like.	0.840
LOC114849798	LOC114852309	ENSBSLP00000023947	ENSBSLP00000009486	Cathepsin B-like.	Lysosomal protective protein-like.	0.747
LOC114849798	LOC114864300	ENSBSLP00000023947	ENSBSLP00000028681	Cathepsin B-like.	Cathepsin F-like.	0.811
LOC114849798	LOC114870387	ENSBSLP00000023947	ENSBSLP00000054097	Cathepsin B-like.	Alpha-1-antitrypsin-like protein GS55-MS.	0.683
LOC114849798	ctsa	ENSBSLP00000023947	ENSBSLP00000008569	Cathepsin B-like.	Cathepsin A.	0.747
LOC114849798	ctsc	ENSBSLP00000023947	ENSBSLP00000032438	Cathepsin B-like.	Cathepsin C.	0.857
LOC114849798	ctsh	ENSBSLP00000023947	ENSBSLP00000048372	Cathepsin B-like.	Cathepsin H.	0.887
LOC114849798	ctso	ENSBSLP00000023947	ENSBSLP00000039871	Cathepsin B-like.	Cathepsin O.	0.849
LOC114852126	LOC114845438	ENSBSLP00000020575	ENSBSLP00000050384	Cathepsin B-like.	Pepsin A-like.	0.672

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

38

average node degree:

6.91

avg. local clustering coefficient:

0.859

expected number of edges:

13

PPI enrichment p-value:

5.81e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007218

Neuropeptide signaling pathway

5 of 111

1.96

2.45

6.23e-06

GO:0007186

G protein-coupled receptor signaling pathway

11 of 1020

1.34

2.31

1.52e-11

GO:0007600

Sensory perception

4 of 347

1.37

0.8

0.0161

GO:0003008

System process

6 of 1127

1.03

0.74

0.0062

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031681

G-protein beta-subunit binding

5 of 26

2.59

4.36

4.38e-09

GO:0001664

G protein-coupled receptor binding

4 of 194

1.62

1.31

0.0013

GO:0048018

Receptor ligand activity

5 of 421

1.38

1.16

0.0013

GO:0005515

Protein binding

11 of 6815

0.52

0.41

0.0013

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005834

Heterotrimeric G-protein complex

5 of 50

2.31

3.68

4.27e-08

GO:0030141

Secretory granule

3 of 149

1.61

1.08

0.0051

GO:0030425

Dendrite

4 of 389

1.32

0.99

0.0035

GO:0043679

Axon terminus

2 of 50

1.91

0.85

0.0241

GO:0005886

Plasma membrane

8 of 5191

0.5

0.31

0.0462

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:21631

Mixed, incl. GTPase complex, and G protein-coupled amine receptor activity

7 of 147

1.99

3.86

9.47e-10

CL:22019

Galanin receptor activity, and Neuropeptide binding

4 of 15

2.73

3.83

7.03e-08

CL:21640

GTPase complex, and G protein-coupled amine receptor activity

6 of 115

2.03

3.51

1.53e-08

CL:21653

G beta:gamma signalling through BTK, and Amino terminal of the G-protein receptor rhodopsin

4 of 23

2.55

3.45

2.82e-07

CL:22023

Vertebrate endogenous opioids neuropeptide, and Neuropeptide binding

3 of 6

3.01

3.06

2.63e-06

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04371

Apelin signaling pathway

5 of 208

1.69

2.15

6.51e-06

map04080

Neuroactive ligand-receptor interaction

6 of 706

1.24

1.34

4.05e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-202040

G-protein activation

8 of 38

2.63

8.11

4.57e-17

MAP-111885

Opioid Signalling

8 of 114

2.15

5.71

4.18e-14

MAP-418594

G alpha (i) signalling events

11 of 430

1.72

4.43

1.28e-16

MAP-392451

G beta:gamma signalling through PI3Kgamma

5 of 39

2.42

4.36

2.21e-09

MAP-381676

Glucagon-like Peptide-1 (GLP1) regulates insulin secretion

5 of 46

2.34

4.16

4.25e-09

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005834

Heterotrimeric G-protein complex

4 of 15

2.73

3.61

1.85e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0449

Lipoprotein

5 of 64

2.2

3.59

3.79e-08

KW-0807

Transducer

6 of 629

1.29

1.42

3.61e-05

KW-1003

Cell membrane

5 of 464

1.34

1.33

0.00019

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01160

Vertebrate endogenous opioids neuropeptide

2 of 3

3.13

1.28

0.0050

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00224

G protein gamma subunit-like motifs

5 of 22

2.66

4.83

6.16e-10

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