fermt2 protein (Betta splendens) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

fermt2

Fermitin family member 2. (703 aa)

Predicted Functional Partners:

ILK

0.831

fblim1

0.823

LOC114869209

0.794

itgb6

0.756

itgb4

0.744

LOC114847462

0.740

itgb5

0.739

LOC114853385

0.733

trip6

0.733

itgb8

0.725

Your Current Organism:

Betta splendens

NCBI taxonomy Id: 158456
Other names: B. splendens, Siamese fighting fish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ILK	LOC114847462	ENSBSLP00000019239	ENSBSLP00000017335	Integrin linked kinase.	Integrin beta-2-like.	0.861
ILK	LOC114869209	ENSBSLP00000019239	ENSBSLP00000024996	Integrin linked kinase.	Integrin-linked protein kinase-like.	0.839
ILK	fermt2	ENSBSLP00000019239	ENSBSLP00000052011	Integrin linked kinase.	Fermitin family member 2.	0.831
ILK	itgb4	ENSBSLP00000019239	ENSBSLP00000037009	Integrin linked kinase.	Integrin subunit beta 4.	0.787
ILK	itgb5	ENSBSLP00000019239	ENSBSLP00000054991	Integrin linked kinase.	Integrin subunit beta 5.	0.748
ILK	itgb6	ENSBSLP00000019239	ENSBSLP00000029254	Integrin linked kinase.	Integrin subunit beta 6.	0.783
ILK	itgb8	ENSBSLP00000019239	ENSBSLP00000026375	Integrin linked kinase.	Integrin subunit beta 8.	0.773
LOC114847462	ILK	ENSBSLP00000017335	ENSBSLP00000019239	Integrin beta-2-like.	Integrin linked kinase.	0.861
LOC114847462	LOC114869209	ENSBSLP00000017335	ENSBSLP00000024996	Integrin beta-2-like.	Integrin-linked protein kinase-like.	0.861
LOC114847462	fermt2	ENSBSLP00000017335	ENSBSLP00000052011	Integrin beta-2-like.	Fermitin family member 2.	0.740
LOC114847462	itgb4	ENSBSLP00000017335	ENSBSLP00000037009	Integrin beta-2-like.	Integrin subunit beta 4.	0.931
LOC114847462	itgb5	ENSBSLP00000017335	ENSBSLP00000054991	Integrin beta-2-like.	Integrin subunit beta 5.	0.941
LOC114847462	itgb6	ENSBSLP00000017335	ENSBSLP00000029254	Integrin beta-2-like.	Integrin subunit beta 6.	0.943
LOC114847462	itgb8	ENSBSLP00000017335	ENSBSLP00000026375	Integrin beta-2-like.	Integrin subunit beta 8.	0.932
LOC114853385	fermt2	ENSBSLP00000007331	ENSBSLP00000052011	Lipoma-preferred partner homolog.	Fermitin family member 2.	0.733
LOC114869209	ILK	ENSBSLP00000024996	ENSBSLP00000019239	Integrin-linked protein kinase-like.	Integrin linked kinase.	0.839
LOC114869209	LOC114847462	ENSBSLP00000024996	ENSBSLP00000017335	Integrin-linked protein kinase-like.	Integrin beta-2-like.	0.861
LOC114869209	fermt2	ENSBSLP00000024996	ENSBSLP00000052011	Integrin-linked protein kinase-like.	Fermitin family member 2.	0.794
LOC114869209	itgb4	ENSBSLP00000024996	ENSBSLP00000037009	Integrin-linked protein kinase-like.	Integrin subunit beta 4.	0.787
LOC114869209	itgb5	ENSBSLP00000024996	ENSBSLP00000054991	Integrin-linked protein kinase-like.	Integrin subunit beta 5.	0.748

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

10

average node degree:

1.82

avg. local clustering coefficient:

0.909

expected number of edges:

11

PPI enrichment p-value:

0.62

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030177

Positive regulation of Wnt signaling pathway

6 of 96

2.06

3.43

3.52e-08

GO:0030111

Regulation of Wnt signaling pathway

8 of 248

1.77

3.35

1.03e-09

GO:0016055

Wnt signaling pathway

5 of 182

1.7

1.77

0.00010

GO:2001013

Epithelial cell proliferation involved in renal tubule morphogenesis

2 of 4

2.96

1.33

0.0040

GO:0060828

Regulation of canonical Wnt signaling pathway

4 of 190

1.59

1.15

0.0031

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016500

Protein-hormone receptor activity

3 of 19

2.46

1.75

0.00055

GO:0008201

Heparin binding

4 of 129

1.76

1.45

0.00086

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005576

Extracellular region

7 of 1991

0.81

0.47

0.0325

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:27104524

(2016) Exogenous R-Spondin1 Induces Precocious Telogen-to-Anagen Transition in Mouse Hair Follicles.

9 of 37

2.65

8.72

2.25e-18

PMID:29416699

(2018) LGR5 and LGR6 in stem cell biology and ovarian cancer.

7 of 16

2.9

7.43

8.53e-15

PMID:22982762

(2012) The R-spondin family of proteins: emerging regulators of WNT signaling.

7 of 53

2.38

5.37

8.90e-12

PMID:25276837

(2014) Computational biophysical, biochemical, and evolutionary signature of human R-spondin family proteins, the member of canonical Wntbeta-catenin signaling pathway.

5 of 25

2.56

3.91

3.36e-08

PMID:38255775

(2024) Adult Animal Stem Cell-Derived Organoids in Biomedical Research and the One Health Paradigm.

5 of 45

2.31

3.24

3.98e-07

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15139

Mixed, incl. Regulation of FZD by ubiquitination, and WSC domain

9 of 14

3.07

11.51

1.31e-22

CL:15143

Epithelial cell proliferation involved in renal tubule morphogenesis, and Furin-like repeat

5 of 5

3.26

6.25

3.73e-12

CL:20511

Teneurin Intracellular Region, and Latrophilin Cytoplasmic C-terminal region

2 of 6

2.79

1.24

0.0057

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

cfa04310

Wnt signaling pathway

8 of 135

2.04

5.08

2.77e-13

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

CFA-4641263

Regulation of FZD by ubiquitination

7 of 15

2.93

8.16

3.29e-16

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0000305

Crypt

2 of 9

2.61

0.84

0.0302

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0732

Signal

7 of 2280

0.75

0.47

0.0212

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02354

Latrophilin Cytoplasmic C-terminal region

2 of 3

3.09

1.22

0.0062

PF02140

Galactose binding lectin domain

2 of 5

2.87

1.21

0.0065

PF16489

GPCR-Autoproteolysis INducing (GAIN) domain

2 of 10

2.56

1.02

0.0136

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00261

Furin-like repeats

4 of 16

2.66

3.59

1.85e-07

SM00209

Thrombospondin type 1 repeats

4 of 61

2.08

2.41

1.28e-05

SM00284

Olfactomedin-like domains

2 of 14

2.42

1.12

0.0087

SM00008

Domain present in hormone receptors

2 of 23

2.2

1.01

0.0130

SM00369

Leucine-rich repeats, typical (most populated) subfamily

3 of 122

1.65

1.0

0.0087

(more ...)

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