neto2 protein (Betta splendens) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

neto2

Neuropilin and tolloid like 2. (615 aa)

Predicted Functional Partners:

LOC114866502

0.524

LOC114869650

0.485

LOC114849248

0.485

GRIK2

0.485

grik1

0.485

GRIK3

0.485

ENSBSLP00000007389

0.439

GRIK4

0.439

grik5

0.439

LOC114866081

0.439

Your Current Organism:

Betta splendens

NCBI taxonomy Id: 158456
Other names: B. splendens, Siamese fighting fish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSBSLP00000007389	GRIK2	ENSBSLP00000007389	ENSBSLP00000027991	annotation not available	Glutamate ionotropic receptor kainate type subunit 2.	0.788
ENSBSLP00000007389	GRIK3	ENSBSLP00000007389	ENSBSLP00000046666	annotation not available	Glutamate ionotropic receptor kainate type subunit 3.	0.788
ENSBSLP00000007389	LOC114849248	ENSBSLP00000007389	ENSBSLP00000024831	annotation not available	Glutamate receptor ionotropic, kainate 2-like.	0.788
ENSBSLP00000007389	LOC114866502	ENSBSLP00000007389	ENSBSLP00000039452	annotation not available	Glutamate receptor ionotropic, NMDA 1.	0.743
ENSBSLP00000007389	LOC114869650	ENSBSLP00000007389	ENSBSLP00000005958	annotation not available	Glutamate receptor ionotropic, kainate 1-like.	0.788
ENSBSLP00000007389	grik1	ENSBSLP00000007389	ENSBSLP00000044966	annotation not available	Glutamate ionotropic receptor kainate type subunit 1.	0.788
ENSBSLP00000007389	neto2	ENSBSLP00000007389	ENSBSLP00000054711	annotation not available	Neuropilin and tolloid like 2.	0.439
GRIK2	ENSBSLP00000007389	ENSBSLP00000027991	ENSBSLP00000007389	Glutamate ionotropic receptor kainate type subunit 2.	annotation not available	0.788
GRIK2	GRIK4	ENSBSLP00000027991	ENSBSLP00000008462	Glutamate ionotropic receptor kainate type subunit 2.	Glutamate ionotropic receptor kainate type subunit 4.	0.795
GRIK2	LOC114866081	ENSBSLP00000027991	ENSBSLP00000011730	Glutamate ionotropic receptor kainate type subunit 2.	Glutamate receptor ionotropic, kainate 5-like.	0.794
GRIK2	LOC114866502	ENSBSLP00000027991	ENSBSLP00000039452	Glutamate ionotropic receptor kainate type subunit 2.	Glutamate receptor ionotropic, NMDA 1.	0.737
GRIK2	LOC114869650	ENSBSLP00000027991	ENSBSLP00000005958	Glutamate ionotropic receptor kainate type subunit 2.	Glutamate receptor ionotropic, kainate 1-like.	0.589
GRIK2	grik1	ENSBSLP00000027991	ENSBSLP00000044966	Glutamate ionotropic receptor kainate type subunit 2.	Glutamate ionotropic receptor kainate type subunit 1.	0.589
GRIK2	grik5	ENSBSLP00000027991	ENSBSLP00000010801	Glutamate ionotropic receptor kainate type subunit 2.	Glutamate ionotropic receptor kainate type subunit 5.	0.794
GRIK2	neto2	ENSBSLP00000027991	ENSBSLP00000054711	Glutamate ionotropic receptor kainate type subunit 2.	Neuropilin and tolloid like 2.	0.485
GRIK3	ENSBSLP00000007389	ENSBSLP00000046666	ENSBSLP00000007389	Glutamate ionotropic receptor kainate type subunit 3.	annotation not available	0.788
GRIK3	GRIK4	ENSBSLP00000046666	ENSBSLP00000008462	Glutamate ionotropic receptor kainate type subunit 3.	Glutamate ionotropic receptor kainate type subunit 4.	0.794
GRIK3	LOC114866081	ENSBSLP00000046666	ENSBSLP00000011730	Glutamate ionotropic receptor kainate type subunit 3.	Glutamate receptor ionotropic, kainate 5-like.	0.797
GRIK3	LOC114866502	ENSBSLP00000046666	ENSBSLP00000039452	Glutamate ionotropic receptor kainate type subunit 3.	Glutamate receptor ionotropic, NMDA 1.	0.737
GRIK3	grik5	ENSBSLP00000046666	ENSBSLP00000010801	Glutamate ionotropic receptor kainate type subunit 3.	Glutamate ionotropic receptor kainate type subunit 5.	0.796

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

24

average node degree:

4.36

avg. local clustering coefficient:

0.903

expected number of edges:

10

PPI enrichment p-value:

0.000173

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006260

DNA replication

8 of 46

1.55

2.55

1.08e-08

GO:0006259

DNA metabolic process

9 of 117

1.19

1.57

1.10e-07

GO:0006261

DNA-templated DNA replication

3 of 16

1.58

1.09

0.0046

GO:0034654

Nucleobase-containing compound biosynthetic process

6 of 108

1.05

0.92

0.00065

GO:0006269

DNA replication, synthesis of RNA primer

2 of 5

1.91

0.87

0.0220

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003887

DNA-directed DNA polymerase activity

4 of 14

1.76

1.71

0.00019

GO:0016779

Nucleotidyltransferase activity

5 of 36

1.45

0.00019

GO:0140097

Catalytic activity, acting on DNA

6 of 66

1.26

1.25

0.00019

GO:0140640

Catalytic activity, acting on a nucleic acid

7 of 150

0.97

0.91

0.00019

GO:0003677

DNA binding

8 of 187

0.94

0.86

0.00019

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030894

Replisome

3 of 6

2.0

1.57

0.00080

GO:0061695

Transferase complex, transferring phosphorus-containing groups

3 of 9

1.83

1.5

0.00080

GO:0009360

DNA polymerase III complex

2 of 3

2.13

1.33

0.0030

GO:0140535

Intracellular protein-containing complex

3 of 15

1.61

1.28

0.0015

GO:1990077

Primosome complex

2 of 4

2.0

1.26

0.0036

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:575

DNA replication, and Bacterial nucleoid

8 of 14

2.06

5.07

5.57e-13

CL:523

Mismatch repair, and DNA damage

10 of 40

1.7

3.97

6.50e-14

CL:591

Primosome, and Bacterial nucleoid

4 of 6

2.13

2.61

5.39e-06

CL:579

DNA polymerase III subunits gamma and tau domain III, and Helix-hairpin-helix motif

3 of 5

2.08

1.77

0.00034

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03030

DNA replication

7 of 31

1.66

2.86

7.89e-09

map03430

Mismatch repair

6 of 27

1.65

2.54

1.54e-07

map03440

Homologous recombination

6 of 36

1.53

2.18

4.78e-07

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009360

DNA polymerase III complex

3 of 4

2.18

1.87

0.00024

GOCC:0061695

Transferase complex, transferring phosphorus-containing groups

5 of 31

1.51

1.62

8.25e-05

GOCC:1990077

Primosome complex

2 of 6

1.83

0.87

0.0204

GOCC:1902494

Catalytic complex

6 of 130

0.97

0.83

0.00077

GOCC:0032991

Protein-containing complex

7 of 315

0.65

0.46

0.0093

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0235

DNA replication

6 of 15

1.91

3.25

2.46e-08

KW-0238

DNA-binding

7 of 105

1.13

1.24

1.61e-05

KW-0639

Primosome

2 of 2

2.31

1.14

0.0076

KW-0239

DNA-directed DNA polymerase

2 of 5

1.91

0.94

0.0159

KW-0548

Nucleotidyltransferase

3 of 22

1.44

0.93

0.0084

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR027417

P-loop containing nucleoside triphosphate hydrolase

7 of 152

0.97

0.78

0.0019

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