node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
coaBC | dut | LH23_05540 | LH23_05535 | Bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.995 |
coaBC | slmA | LH23_05540 | LH23_05530 | Bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Division inhibitor protein; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. | 0.599 |
coaBC | thyA | LH23_05540 | LH23_01345 | Bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.709 |
dcd | dut | LH23_20770 | LH23_05535 | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.905 |
dcd | ndk | LH23_20770 | LH23_23195 | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.798 |
dcd | nrdA_1 | LH23_20770 | LH23_21445 | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | Ribonucleotide-diphosphate reductase subunit alpha; Catalyzes the rate-limiting step in dNTP synthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.849 |
dcd | nrdD_2 | LH23_20770 | LH23_02700 | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | Ribonucleoside-triphosphate reductase; Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.858 |
dcd | nrdE_1 | LH23_20770 | LH23_00725 | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | Ribonucleotide-diphosphate reductase subunit alpha; Catalyzes the rate-limiting step in dNTP synthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.660 |
dcd | tdk | LH23_20770 | LH23_18430 | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | Thymidine kinase; Catalyzes the formation of thymidine 5'-phosphate from thymidine; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.754 |
dcd | thyA | LH23_20770 | LH23_01345 | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.801 |
dnaN | dut | LH23_04690 | LH23_05535 | DNA polymerase III subunit beta; Binds the polymerase to DNA and acts as a sliding clamp; Derived by automated computational analysis using gene prediction method: Protein Homology. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.906 |
dnaN | nrdA_1 | LH23_04690 | LH23_21445 | DNA polymerase III subunit beta; Binds the polymerase to DNA and acts as a sliding clamp; Derived by automated computational analysis using gene prediction method: Protein Homology. | Ribonucleotide-diphosphate reductase subunit alpha; Catalyzes the rate-limiting step in dNTP synthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.871 |
dnaN | nrdE_1 | LH23_04690 | LH23_00725 | DNA polymerase III subunit beta; Binds the polymerase to DNA and acts as a sliding clamp; Derived by automated computational analysis using gene prediction method: Protein Homology. | Ribonucleotide-diphosphate reductase subunit alpha; Catalyzes the rate-limiting step in dNTP synthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.871 |
dnaN | tdk | LH23_04690 | LH23_18430 | DNA polymerase III subunit beta; Binds the polymerase to DNA and acts as a sliding clamp; Derived by automated computational analysis using gene prediction method: Protein Homology. | Thymidine kinase; Catalyzes the formation of thymidine 5'-phosphate from thymidine; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.436 |
dnaN | thyA | LH23_04690 | LH23_01345 | DNA polymerase III subunit beta; Binds the polymerase to DNA and acts as a sliding clamp; Derived by automated computational analysis using gene prediction method: Protein Homology. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.903 |
dut | coaBC | LH23_05535 | LH23_05540 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.995 |
dut | dcd | LH23_05535 | LH23_20770 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | 0.905 |
dut | dnaN | LH23_05535 | LH23_04690 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | DNA polymerase III subunit beta; Binds the polymerase to DNA and acts as a sliding clamp; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.906 |
dut | ndk | LH23_05535 | LH23_23195 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.896 |
dut | nrdA_1 | LH23_05535 | LH23_21445 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Ribonucleotide-diphosphate reductase subunit alpha; Catalyzes the rate-limiting step in dNTP synthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.910 |