node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KXB90188.1 | murI | HMPREF3182_01502 | HMPREF3182_01105 | Putative stage III sporulation protein E; KEGG: reh:H16_A1582 8.4e-109 h16_A1582; DNA translocase FtsK K03466; Psort location: CytoplasmicMembrane, score: 10.00; Belongs to the FtsK/SpoIIIE/SftA family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.611 |
KXB90219.1 | KXB90546.1 | HMPREF3182_01533 | HMPREF3182_01301 | Glutamate dehydrogenase, NAD-specific; KEGG: med:MELS_0760 1.4e-218 glu/Leu/Phe/Val dehydrogenase; K00262 glutamate dehydrogenase (NADP+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | KEGG: med:MELS_0569 0. phosphoribosylformylglycinamidine synthase; K01952 phosphoribosylformylglycinamidine synthase; Psort location: CytoplasmicMembrane, score: 8.46. | 0.807 |
KXB90219.1 | guaB | HMPREF3182_01533 | HMPREF3182_00189 | Glutamate dehydrogenase, NAD-specific; KEGG: med:MELS_0760 1.4e-218 glu/Leu/Phe/Val dehydrogenase; K00262 glutamate dehydrogenase (NADP+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.512 |
KXB90219.1 | murI | HMPREF3182_01533 | HMPREF3182_01105 | Glutamate dehydrogenase, NAD-specific; KEGG: med:MELS_0760 1.4e-218 glu/Leu/Phe/Val dehydrogenase; K00262 glutamate dehydrogenase (NADP+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.876 |
KXB90546.1 | KXB90219.1 | HMPREF3182_01301 | HMPREF3182_01533 | KEGG: med:MELS_0569 0. phosphoribosylformylglycinamidine synthase; K01952 phosphoribosylformylglycinamidine synthase; Psort location: CytoplasmicMembrane, score: 8.46. | Glutamate dehydrogenase, NAD-specific; KEGG: med:MELS_0760 1.4e-218 glu/Leu/Phe/Val dehydrogenase; K00262 glutamate dehydrogenase (NADP+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.807 |
KXB90546.1 | KXB90678.1 | HMPREF3182_01301 | HMPREF3182_01102 | KEGG: med:MELS_0569 0. phosphoribosylformylglycinamidine synthase; K01952 phosphoribosylformylglycinamidine synthase; Psort location: CytoplasmicMembrane, score: 8.46. | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.419 |
KXB90546.1 | KXB91910.1 | HMPREF3182_01301 | HMPREF3182_00649 | KEGG: med:MELS_0569 0. phosphoribosylformylglycinamidine synthase; K01952 phosphoribosylformylglycinamidine synthase; Psort location: CytoplasmicMembrane, score: 8.46. | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | 0.413 |
KXB90546.1 | guaB | HMPREF3182_01301 | HMPREF3182_00189 | KEGG: med:MELS_0569 0. phosphoribosylformylglycinamidine synthase; K01952 phosphoribosylformylglycinamidine synthase; Psort location: CytoplasmicMembrane, score: 8.46. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.928 |
KXB90546.1 | murD | HMPREF3182_01301 | HMPREF3182_00257 | KEGG: med:MELS_0569 0. phosphoribosylformylglycinamidine synthase; K01952 phosphoribosylformylglycinamidine synthase; Psort location: CytoplasmicMembrane, score: 8.46. | UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.782 |
KXB90546.1 | murI | HMPREF3182_01301 | HMPREF3182_01105 | KEGG: med:MELS_0569 0. phosphoribosylformylglycinamidine synthase; K01952 phosphoribosylformylglycinamidine synthase; Psort location: CytoplasmicMembrane, score: 8.46. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.803 |
KXB90678.1 | KXB90546.1 | HMPREF3182_01102 | HMPREF3182_01301 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | KEGG: med:MELS_0569 0. phosphoribosylformylglycinamidine synthase; K01952 phosphoribosylformylglycinamidine synthase; Psort location: CytoplasmicMembrane, score: 8.46. | 0.419 |
KXB90678.1 | KXB90679.1 | HMPREF3182_01102 | HMPREF3182_01103 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Hypothetical protein; KEGG: cai:Caci_5966 3.8e-12 asparagine synthase K01953. | 0.791 |
KXB90678.1 | KXB90680.1 | HMPREF3182_01102 | HMPREF3182_01104 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Hypothetical protein. | 0.744 |
KXB90678.1 | KXB90682.1 | HMPREF3182_01102 | HMPREF3182_01106 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | acyl-CoA thioester hydrolase, YbgC/YbaW family; KEGG: med:MELS_1786 1.2e-38 hypothetical protein; K07107 acyl-CoA thioester hydrolase; Psort location: Cytoplasmic, score: 8.96. | 0.611 |
KXB90678.1 | guaB | HMPREF3182_01102 | HMPREF3182_00189 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.920 |
KXB90678.1 | murD | HMPREF3182_01102 | HMPREF3182_00257 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.477 |
KXB90678.1 | murI | HMPREF3182_01102 | HMPREF3182_01105 | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.959 |
KXB90679.1 | KXB90678.1 | HMPREF3182_01103 | HMPREF3182_01102 | Hypothetical protein; KEGG: cai:Caci_5966 3.8e-12 asparagine synthase K01953. | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.791 |
KXB90679.1 | KXB90680.1 | HMPREF3182_01103 | HMPREF3182_01104 | Hypothetical protein; KEGG: cai:Caci_5966 3.8e-12 asparagine synthase K01953. | Hypothetical protein. | 0.767 |
KXB90679.1 | KXB90682.1 | HMPREF3182_01103 | HMPREF3182_01106 | Hypothetical protein; KEGG: cai:Caci_5966 3.8e-12 asparagine synthase K01953. | acyl-CoA thioester hydrolase, YbgC/YbaW family; KEGG: med:MELS_1786 1.2e-38 hypothetical protein; K07107 acyl-CoA thioester hydrolase; Psort location: Cytoplasmic, score: 8.96. | 0.641 |