thiM protein (Lactobacillus pentosus) - STRING interaction network

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Predicted Interactions

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thiM

Unannotated protein; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (264 aa)

Predicted Functional Partners:

thiE

0.999

BB562_00475

0.998

BB562_00485

0.907

BB562_00490

0.534

BB562_10235

0.482

Your Current Organism:

Lactobacillus pentosus

NCBI taxonomy Id: 1589
Other names: ATCC 8041, CCUG 33455, CIP 103156, DSM 20314, L. pentosus, LMG 10755, LMG:10755, NCAIM B.01727, NCCB 32014, NCDO 363, NCIMB 8026, NRRL B-227, NRRL B-473

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BB562_00475	BB562_00485	GCA_001188985_00427	GCA_001188985_00425	Unannotated protein.	Unannotated protein.	0.900
BB562_00475	BB562_00490	GCA_001188985_00427	GCA_001188985_00424	Unannotated protein.	Unannotated protein.	0.569
BB562_00475	BB562_10235	GCA_001188985_00427	GCA_001188985_03059	Unannotated protein.	Unannotated protein; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.	0.625
BB562_00475	thiE	GCA_001188985_00427	GCA_001188985_00426	Unannotated protein.	Unannotated protein; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.	0.999
BB562_00475	thiM	GCA_001188985_00427	GCA_001188985_00428	Unannotated protein.	Unannotated protein; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family.	0.998
BB562_00485	BB562_00475	GCA_001188985_00425	GCA_001188985_00427	Unannotated protein.	Unannotated protein.	0.900
BB562_00485	BB562_00490	GCA_001188985_00425	GCA_001188985_00424	Unannotated protein.	Unannotated protein.	0.553
BB562_00485	thiE	GCA_001188985_00425	GCA_001188985_00426	Unannotated protein.	Unannotated protein; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.	0.897
BB562_00485	thiM	GCA_001188985_00425	GCA_001188985_00428	Unannotated protein.	Unannotated protein; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family.	0.907
BB562_00490	BB562_00475	GCA_001188985_00424	GCA_001188985_00427	Unannotated protein.	Unannotated protein.	0.569
BB562_00490	BB562_00485	GCA_001188985_00424	GCA_001188985_00425	Unannotated protein.	Unannotated protein.	0.553
BB562_00490	thiE	GCA_001188985_00424	GCA_001188985_00426	Unannotated protein.	Unannotated protein; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.	0.573
BB562_00490	thiM	GCA_001188985_00424	GCA_001188985_00428	Unannotated protein.	Unannotated protein; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family.	0.534
BB562_10235	BB562_00475	GCA_001188985_03059	GCA_001188985_00427	Unannotated protein; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.	Unannotated protein.	0.625
BB562_10235	thiE	GCA_001188985_03059	GCA_001188985_00426	Unannotated protein; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.	Unannotated protein; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.	0.478
BB562_10235	thiM	GCA_001188985_03059	GCA_001188985_00428	Unannotated protein; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.	Unannotated protein; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family.	0.482
thiE	BB562_00475	GCA_001188985_00426	GCA_001188985_00427	Unannotated protein; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.	Unannotated protein.	0.999
thiE	BB562_00485	GCA_001188985_00426	GCA_001188985_00425	Unannotated protein; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.	Unannotated protein.	0.897
thiE	BB562_00490	GCA_001188985_00426	GCA_001188985_00424	Unannotated protein; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.	Unannotated protein.	0.573
thiE	BB562_10235	GCA_001188985_00426	GCA_001188985_03059	Unannotated protein; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.	Unannotated protein; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.	0.478

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Network Stats

number of nodes:

11

number of edges:

30

average node degree:

5.45

avg. local clustering coefficient:

0.702

expected number of edges:

11

PPI enrichment p-value:

6.94e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006351

Transcription, DNA-templated

4 of 20

1.66

1.68

0.00015

GO:0010467

Gene expression

11 of 212

1.08

1.43

2.10e-09

GO:0006412

Translation

7 of 96

1.22

1.4

1.16e-05

GO:0009059

Macromolecule biosynthetic process

11 of 256

0.99

1.22

7.95e-09

GO:0044271

Cellular nitrogen compound biosynthetic process

11 of 309

0.91

1.04

4.02e-08

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003899

DNA-directed 5-3 RNA polymerase activity

4 of 6

2.18

2.68

4.52e-06

GO:0019843

rRNA binding

7 of 42

1.58

2.43

1.15e-07

GO:0003735

Structural constituent of ribosome

7 of 52

1.49

2.17

2.25e-07

GO:0003676

Nucleic acid binding

11 of 388

0.81

0.85

2.49e-07

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000428

DNA-directed RNA polymerase complex

4 of 5

2.26

3.03

9.92e-07

GO:0005840

Ribosome

7 of 56

1.46

2.14

1.41e-07

GO:0015935

Small ribosomal subunit

2 of 6

1.88

1.21

0.0040

GO:0032991

Protein-containing complex

6 of 158

0.94

0.85

0.00024

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:32589566

(2020) Comparative genomics of the genus Roseburia reveals divergent biosynthetic pathways that may influence colonic competition among species.

3 of 43

1.2

0.65

0.0301

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:188

Mixed, incl. Small ribosomal subunit, and K Homology domain, type 2

5 of 7

2.21

3.52

5.93e-08

CL:379

RNA polymerase complex, and Helicase superfamily c-terminal domain

4 of 6

2.18

2.79

2.53e-06

CL:80

Structural constituent of ribosome, and Translation regulator activity

7 of 65

1.39

1.93

3.84e-07

CL:66

Translation, and ATP synthesis

11 of 163

1.19

1.8

6.77e-11

CL:89

Small ribosomal subunit, and Structural constituent of ribosome

2 of 10

1.66

0.72

0.0370

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03020

RNA polymerase

4 of 6

2.18

2.82

2.12e-06

map03010

Ribosome

7 of 56

1.46

2.15

1.36e-07

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9635486

Infection with Mycobacterium tuberculosis

4 of 43

1.33

1.23

0.00047

MAP-5663205

Infectious disease

4 of 44

1.32

1.22

0.00047

MAP-1643685

Disease

4 of 46

1.3

1.2

0.00047

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005840

Ribosome

6 of 43

1.51

1.95

3.64e-06

GOCC:0022627

Cytosolic small ribosomal subunit

3 of 7

1.99

1.7

0.00040

GOCC:0000428

DNA-directed RNA polymerase complex

4 of 32

1.46

1.37

0.00040

GOCC:0043229

Intracellular organelle

7 of 189

0.93

0.84

0.00028

GOCC:0032991

Protein-containing complex

7 of 339

0.68

0.52

0.0025

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0240

DNA-directed RNA polymerase

4 of 5

2.26

3.04

9.04e-07

KW-0699

rRNA-binding

7 of 40

1.6

2.61

2.80e-08

KW-0689

Ribosomal protein

7 of 59

1.43

2.08

1.69e-07

KW-0548

Nucleotidyltransferase

4 of 41

1.35

1.19

0.00082

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