STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (413 aa)    
Predicted Functional Partners:
SIP88381.1
Adenylosuccinate lyase.
 0.997
guaB
IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
 
 
 0.995
SIP99395.1
GMP synthase (glutamine-hydrolysing).
 
  
 0.990
SIP99244.1
Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase.
  
 0.944
SIP99221.1
Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase.
  
 0.942
SIQ12998.1
Aspartate carbamoyltransferase.
  
 
 0.905
purC
Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family.
  
 0.890
SIQ66796.1
Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 
 0.866
argG
Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily.
  
 
 0.864
SIQ47647.1
5'-nucleotidase; Belongs to the 5'-nucleotidase family.
    
 0.849
Your Current Organism:
Alkalispirochaeta americana
NCBI taxonomy Id: 159291
Other names: A. americana, ATCC BAA-392, Alkalispirochaeta americana (Hoover et al. 2003) Sravanthi et al. 2016, DSM 14872, Spirochaeta americana, Spirochaeta americana Hoover et al. 2003, Spirochaeta sp. ASpG1, strain ASpG1
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