AYP69_00240 protein (Lactobacillus agilis) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

AYP69_00240

Unannotated protein. (615 aa)

Predicted Functional Partners:

BEN83_04575

0.744

BEN83_08770

0.641

BEN83_08115

0.450

BEN83_00960

0.428

Your Current Organism:

Lactobacillus agilis

NCBI taxonomy Id: 1601
Other names: CCUG 31450, CIP 101264, DSM 20509, L. agilis, LMG 9186, LMG:9186, NRRL B-14856

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AYP69_00240	BEN83_00960	GCA_001243975_00744	GCA_001243975_01137	Unannotated protein.	Unannotated protein; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family.	0.428
AYP69_00240	BEN83_04575	GCA_001243975_00744	GCA_001243975_01848	Unannotated protein.	Unannotated protein.	0.744
AYP69_00240	BEN83_08115	GCA_001243975_00744	GCA_001243975_00743	Unannotated protein.	Unannotated protein.	0.450
AYP69_00240	BEN83_08770	GCA_001243975_00744	GCA_001243975_00044	Unannotated protein.	Unannotated protein.	0.641
BEN83_00960	AYP69_00240	GCA_001243975_01137	GCA_001243975_00744	Unannotated protein; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family.	Unannotated protein.	0.428
BEN83_04575	AYP69_00240	GCA_001243975_01848	GCA_001243975_00744	Unannotated protein.	Unannotated protein.	0.744
BEN83_08115	AYP69_00240	GCA_001243975_00743	GCA_001243975_00744	Unannotated protein.	Unannotated protein.	0.450
BEN83_08770	AYP69_00240	GCA_001243975_00044	GCA_001243975_00744	Unannotated protein.	Unannotated protein.	0.641

Network Stats

number of nodes:

11

number of edges:

35

average node degree:

6.36

avg. local clustering coefficient:

0.828

expected number of edges:

16

PPI enrichment p-value:

1.58e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0018106

Peptidyl-histidine phosphorylation

6 of 34

1.72

2.59

2.93e-07

GO:0016310

Phosphorylation

10 of 118

1.4

2.45

7.11e-11

GO:0044237

Cellular metabolic process

11 of 1358

0.38

0.31

0.0075

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003988

acetyl-CoA C-acyltransferase activity

4 of 8

2.18

2.63

5.51e-06

GO:0004673

Protein histidine kinase activity

6 of 39

1.66

2.31

1.35e-06

GO:0016740

Transferase activity

10 of 559

0.73

0.68

1.93e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1891

Peptidyl-histidine modification, and HWE histidine kinase

6 of 12

2.18

3.98

3.53e-09

CL:1892

PAS-associated, C-terminal, and GGDEF domain

4 of 7

2.23

2.89

1.80e-06

CL:3102

Mixed, incl. Thiolase, active site, and 3-hydroxyacyl-CoA dehydrogenase, C-terminal

4 of 15

1.9

2.28

1.26e-05

CL:1905

HWE histidine kinase, and Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

2 of 5

2.08

1.18

0.0056

CL:3106

Thiolase, conserved site, and 3-hydroxyacyl-CoA dehydrogenase activity

2 of 6

2.0

1.12

0.0070

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00900

Terpenoid backbone biosynthesis

4 of 22

1.74

1.88

5.83e-05

map00310

Lysine degradation

4 of 28

1.63

1.72

9.26e-05

map00380

Tryptophan metabolism

4 of 29

1.62

1.71

9.26e-05

map02020

Two-component system

10 of 206

1.16

1.65

1.47e-09

map00640

Propanoate metabolism

4 of 39

1.49

0.00019

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0597

Phosphoprotein

4 of 45

1.43

1.24

0.00086

KW-0012

Acyltransferase

4 of 50

1.38

1.19

0.00096

KW-0418

Kinase

5 of 89

1.23

1.09

0.00067

KW-0808

Transferase

9 of 467

0.76

0.66

0.00021

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02803

Thiolase, C-terminal domain

4 of 7

2.23

2.54

1.01e-05

PF00108

Thiolase, N-terminal domain

3 of 5

2.25

1.81

0.00036

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR020610

Thiolase, active site

4 of 5

2.38

2.61

1.00e-05

IPR020617

Thiolase, C-terminal

4 of 6

2.3

2.58

1.00e-05

IPR020616

Thiolase, N-terminal

4 of 6

2.3

2.58

1.00e-05

IPR002155

Thiolase

4 of 7

2.23

2.55

1.00e-05

IPR016039

Thiolase-like

4 of 13

1.96

2.27

1.74e-05

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00091

PAS domain

4 of 15

1.9

2.36

7.61e-06

SM00388

His Kinase A (phosphoacceptor) domain

5 of 31

1.68

2.19

4.61e-06

SM00387

Histidine kinase-like ATPases

5 of 33

1.66

2.15

4.61e-06

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

3 of 10

1.95

1.89

0.00014

SM00448

cheY-homologous receiver domain

4 of 34

1.55

1.61

0.00011

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