A0A0S6X6E7 protein (fungal sp. No11243) - STRING interaction network

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Cooccurrence

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Score

A0A0S6X6E7

Alpha-mann_mid domain-containing protein. (1109 aa)

Predicted Functional Partners:

A0A0S6XAZ5

0.856

A0A0S6X3R2

0.718

A0A0S6XUS0

0.667

A0A0S6XG29

0.642

A0A0S6X6Y9

0.639

A0A0S6X8C8

0.575

A0A0C9M920

0.526

A0A0S6XAB4

0.499

A0A0C9M9Q6

0.490

A0A0S6XEQ9

0.485

Your Current Organism:

fungal sp. No11243

NCBI taxonomy Id: 1603295
Other names: f. sp. No.11243, fungal sp. No.11243

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A0C9M920	A0A0C9M9Q6	Uncharacterized protein.	Uncharacterized protein.	0.637
A0A0C9M920	A0A0S6X6E7	Uncharacterized protein.	Alpha-mann_mid domain-containing protein.	0.526
A0A0C9M9Q6	A0A0C9M920	Uncharacterized protein.	Uncharacterized protein.	0.637
A0A0C9M9Q6	A0A0S6X6E7	Uncharacterized protein.	Alpha-mann_mid domain-containing protein.	0.490
A0A0C9M9Q6	A0A0S6XAZ5	Uncharacterized protein.	Uncharacterized protein.	0.571
A0A0S6X3R2	A0A0S6X6E7	Uncharacterized protein.	Alpha-mann_mid domain-containing protein.	0.718
A0A0S6X6E7	A0A0C9M920	Alpha-mann_mid domain-containing protein.	Uncharacterized protein.	0.526
A0A0S6X6E7	A0A0C9M9Q6	Alpha-mann_mid domain-containing protein.	Uncharacterized protein.	0.490
A0A0S6X6E7	A0A0S6X3R2	Alpha-mann_mid domain-containing protein.	Uncharacterized protein.	0.718
A0A0S6X6E7	A0A0S6X6Y9	Alpha-mann_mid domain-containing protein.	Uncharacterized protein.	0.639
A0A0S6X6E7	A0A0S6X8C8	Alpha-mann_mid domain-containing protein.	Uncharacterized protein; Belongs to the peptidase M18 family.	0.575
A0A0S6X6E7	A0A0S6XAB4	Alpha-mann_mid domain-containing protein.	DNA_MISMATCH_REPAIR_2 domain-containing protein.	0.499
A0A0S6X6E7	A0A0S6XAZ5	Alpha-mann_mid domain-containing protein.	Uncharacterized protein.	0.856
A0A0S6X6E7	A0A0S6XEQ9	Alpha-mann_mid domain-containing protein.	5'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.	0.485
A0A0S6X6E7	A0A0S6XG29	Alpha-mann_mid domain-containing protein.	Uncharacterized protein.	0.642
A0A0S6X6E7	A0A0S6XUS0	Alpha-mann_mid domain-containing protein.	Uncharacterized protein.	0.667
A0A0S6X6Y9	A0A0S6X6E7	Uncharacterized protein.	Alpha-mann_mid domain-containing protein.	0.639
A0A0S6X8C8	A0A0S6X6E7	Uncharacterized protein; Belongs to the peptidase M18 family.	Alpha-mann_mid domain-containing protein.	0.575
A0A0S6XAB4	A0A0S6X6E7	DNA_MISMATCH_REPAIR_2 domain-containing protein.	Alpha-mann_mid domain-containing protein.	0.499
A0A0S6XAZ5	A0A0C9M9Q6	Uncharacterized protein.	Uncharacterized protein.	0.571

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019265

Glycine biosynthetic process, by transamination of glyoxylate

2 of 4

2.93

1.35

0.0036

GO:0006097

Glyoxylate cycle

2 of 4

2.93

1.35

0.0036

GO:0009070

Serine family amino acid biosynthetic process

3 of 50

2.01

1.29

0.0032

GO:0019287

Isopentenyl diphosphate biosynthetic process, mevalonate pathway

2 of 6

2.75

1.26

0.0051

GO:0019752

Carboxylic acid metabolic process

7 of 1025

1.06

0.91

0.00098

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008453

Alanine-glyoxylate transaminase activity

2 of 2

3.23

1.3

0.0045

GO:0004760

Serine-pyruvate transaminase activity

2 of 2

3.23

1.3

0.0045

GO:0004474

Malate synthase activity

2 of 4

2.93

1.3

0.0045

GO:0004163

Diphosphomevalonate decarboxylase activity

2 of 2

3.23

1.3

0.0045

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005777

Peroxisome

6 of 162

1.8

2.75

2.24e-07

GO:0005782

Peroxisomal matrix

3 of 29

2.24

1.87

0.00026

GO:0009514

Glyoxysome

2 of 4

2.93

1.66

0.00097

GO:0005737

Cytoplasm

11 of 8012

0.37

0.28

0.0162

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:21300

Mixed, incl. D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain, and Glyoxysome

5 of 43

2.29

3.44

1.33e-07

CL:21309

Glycerate kinase activity, and D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site

2 of 6

2.75

1.12

0.0094

CL:21438

Glycine biosynthetic process, by transamination of glyoxylate, and Threonine dehydratase, biosynthetic

2 of 8

2.63

1.07

0.0113

CL:21353

Mixed, incl. Glyoxysome, and Alpha-hydroxy acid dehydrogenase, FMN-dependent

2 of 15

2.35

0.9

0.0227

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00630

Glyoxylate and dicarboxylate metabolism

7 of 132

1.95

4.16

5.59e-11

map01200

Carbon metabolism

7 of 349

1.53

2.46

2.13e-08

map00680

Methane metabolism

4 of 82

1.92

2.43

5.34e-06

map00260

Glycine, serine and threonine metabolism

4 of 148

1.66

1.86

4.21e-05

map04146

Peroxisome

4 of 207

1.51

1.56

0.00013

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9033241

Peroxisomal protein import

5 of 283

1.48

1.39

0.00037

MAP-389661

Glyoxylate metabolism and glycine degradation

3 of 68

1.87

1.27

0.0029

MAP-446199

Synthesis of Dolichyl-phosphate

2 of 10

2.53

1.25

0.0052

MAP-9609507

Protein localization

5 of 430

1.29

1.08

0.0014

MAP-71291

Metabolism of amino acids and derivatives

4 of 518

1.12

0.6

0.0346

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0329

Glyoxylate bypass

2 of 2

3.23

1.81

0.00054

KW-0756

Sterol biosynthesis

2 of 12

2.45

1.3

0.0041

KW-0816

Tricarboxylic acid cycle

2 of 18

2.27

1.28

0.0041

KW-0663

Pyridoxal phosphate

2 of 57

1.77

0.88

0.0189

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01274

Malate synthase

2 of 2

3.23

1.26

0.0053

PF00288

GHMP kinases N terminal domain

2 of 10

2.53

0.85

0.0290

PF00266

Aminotransferase class-V

2 of 13

2.42

0.83

0.0307

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR046363

Malate synthase, N-terminal and TIM-barrel domains

2 of 2

3.23

1.03

0.0142

IPR044856

Malate synthase, C-terminal superfamily

2 of 2

3.23

1.03

0.0142

IPR041431

Mvd1, C-terminal

2 of 2

3.23

1.03

0.0142

IPR029765

Diphosphomevalonate decarboxylase

2 of 2

3.23

1.03

0.0142

IPR024169

Serine-pyruvate aminotransferase/2-aminoethylphosphonate-pyruvate transaminase

2 of 2

3.23

1.03

0.0142

(more ...)

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