Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
thrBHomoserine kinase; Function experimentally demonstrated in the studied genus; enzyme; Belongs to the pseudomonas-type ThrB family. (316 aa)    
Predicted Functional Partners:
PP_0662
Putative Threonine synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.
    
 0.978
thrC
Threonine synthase.
    
 0.956
metB
Cystathionine gamma-synthase.
     
 0.938
PP_0664
Homoserine dehydrogenase; Function of strongly homologous gene; enzyme; Amino acid biosynthesis.
    
 0.931
hom
Homoserine dehydrogenase.
 
  
 0.927
PP_0122
Homologs of previously reported genes of unknown function.
 
    0.889
metX
Homoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the AB hydrolase superfamily. MetX family.
  
   
 0.824
metE
5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase.
     
 0.817
PP_4637
5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase family protein; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
     
 0.817
ilvE
Branched-chain-amino-acid aminotransferase.
     
 0.810
Your Current Organism:
Pseudomonas putida KT2440
NCBI taxonomy Id: 160488
Other names: P. putida KT2440, Pseudomonas putida (strain KT2440), Pseudomonas putida str. KT2440
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.